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REVIEW article
Front. Med.
Sec. Ophthalmology
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1439888
The involvement of Aquaporin 5 in the inflammatory response of primary Sjogren's syndrome dry eye: potential therapeutic targets exploration
Provisionally accepted- 1 Heilongjiang University of Chinese Medicine, Harbin, China
- 2 China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
Sjogren's syndrome (SS) is a chronic autoimmune disease. Mainly due to the infiltration of lymphoplasmic cells into the exocrine glands, especially the salivary glands and lacrimal glands, resulting in reduced tear and saliva secretion. Reduced tear flow can trigger Sjogren's syndrome dry eye (SSDE). Although the pathophysiology of SSDE xerosis remains incompletely understood, recent advances have identified aquaporin-5 (AQP5) as a critical factor in dysregulation of the exocrine gland and epithelium, influencing the clinical presentation of SSDE through modulation of inflammatory microenvironment and tear secretion processes. This review aims to explore AQP5 regulatory mechanisms in SSDE and analyze its potential as a therapeutic target, providing new directions for SSDE treatment.
Keywords: Aquaporin-5, Sjogren's syndrome dry eye, Inflammatory Response, Therapeutic target, lacrimal gland
Received: 28 May 2024; Accepted: 03 Sep 2024.
Copyright: © 2024 Fu, Zhao, Zhao, Zhang, Teng and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zihang Zhao, China Academy of Chinese Medical Sciences, Beijing, 100700, Beijing Municipality, China
Shuang Zhao, Heilongjiang University of Chinese Medicine, Harbin, China
Meiying Zhang, Heilongjiang University of Chinese Medicine, Harbin, China
Xiaoming Teng, Heilongjiang University of Chinese Medicine, Harbin, China
Tiansong Yang, Heilongjiang University of Chinese Medicine, Harbin, China
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