Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Published on 28 Mar 2025

Beyond interferon gamma - decreased cellular response to COVID-19 vaccination booster in patients with autoimmune inflammatory rheumatic diseases

in Vaccines and Molecular Therapeutics

Jakub Wroński
Magdalena Massalska
Bożena Jaszczyk
Anna Felis-Giemza
Anna Kornatka
Magdalena Plebańczyk
Tomasz Burakowski
Brygida Kwiatkowska
Ewa Kuca-Warnawin
Marzena Ciechomska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1568439

415 views

Original Research

Published on 27 Mar 2025

Chimeric receptor-binding domain vaccine design and sequential immunization enhanced broadly neutralizing antibody responses against COVID-19

in Vaccines and Molecular Therapeutics

Xiao Yang
Xin Tang
Ying Sun
Hualong Xi
Wei Peng
Lu Yan
Wenjing Teng
Yang Zang
Chunlai Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1543212

372 views

Original Research

Published on 27 Mar 2025

Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters

in Vaccines and Molecular Therapeutics

Jessica I. Ahmed
Samantha J. Krosta
Mandy N. Reimer
Winnie Cheung
Christine Mesa
Carmen Lopez
Rayeil J. Chua
Farah Alsattari
Alyssia Robinson
Kathy Manguiat

Frontiers in Immunology

doi 10.3389/fimmu.2025.1529134

505 views

Original Research

Published on 27 Mar 2025

Longitudinal cellular and humoral immune responses following COVID-19 BNT162b2-mRNA-based booster vaccination of craft and manual workers in Qatar

in Vaccines and Molecular Therapeutics

Remy Thomas
Ahmed Zaqout
Bakhita Meqbel
Umar Jafar
Nishant N. Vaikath
Abdullah Aldushain
Adviti Naik
Hibah Shaath
Neyla S. Al-Akl
Abdi Adam

Frontiers in Immunology

doi 10.3389/fimmu.2025.1557426

398 views

Original Research

Accepted on 26 Mar 2025

An integrated mutation-based immunoinformatic approach incorporating variability in epitopes: A Study Based on HIV Subtype C

in Vaccines and Molecular Therapeutics

Saurav Kumar Mishra
Neeraj Kumar
Md. Harun Or Rashid
Sharifa Sultana
Turki M Dawoud
Mohammed Bourhia
Georrge John J

Frontiers in Immunology

doi 10.3389/fimmu.2025.1540253

Original Research

Published on 26 Mar 2025

Therapeutic mucosal vaccination of herpes simplex virus type 2 infected guinea pigs with an adenovirus-based vaccine expressing the ribonucleotide reductase 2 and glycoprotein D induces local tissue-resident CD4+ and CD8+ TRM cells associated with protection against recurrent genital herpes

in Vaccines and Molecular Therapeutics

Afshana Quadiri
Swayam Prakash
Hawa Vahed
Jimmy Medhat Tadros
Miyo Sun
Kathy K. Hormi-Carver
Swena Jignesh Patel
Lbachir BenMohamed

Frontiers in Immunology

doi 10.3389/fimmu.2025.1568258

738 views

Original Research

Accepted on 24 Mar 2025

Isolation of human monoclonal antibodies from 4CMenB vaccinees reveals PorB and LOS as the main OMV components inducing cross-strain protection

in Vaccines and Molecular Therapeutics

Giacomo Vezzani
Viola Viviani
Martina Audagnotto
Alessandro Rossi
Paolo Cinelli
Nicola Pacchiani
Chiara Limongi
Laura Santini
Fabiola Giusti
Sara Tomei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565862

113 views

Original Research

Published on 24 Mar 2025

A bivalent mRNA vaccine against RSV infection in rodent models

in Vaccines and Molecular Therapeutics

Juan Liu
Hanqing Zhao
Wenhao Wang
Binbin Yang
Naifang Zhang
Yu Zhang
Jie Qian
Qiaofang Ma
Yankun Lu
Huafeng Han

Frontiers in Immunology

doi 10.3389/fimmu.2025.1542592

804 views

Mini Review

Published on 24 Mar 2025

Microenvironments of tuberculous granuloma: advances and opportunities for therapy

in Vaccines and Molecular Therapeutics

Gesa Krueger
Shah Faisal
Anca Dorhoi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1575133

883 views

Correction

Published on 21 Mar 2025

Corrigendum: Enhancing AAV-microdystrophin gene therapy after repeat dosing by blocking phagocytosis

in Vaccines and Molecular Therapeutics

Rita Spathis
Deeva Robles Kuriplach
Sabrina Narvesen
Matthew Eybs
Karen Huang
Steven Torres
Madison King
Elizabeth Bagley
Pia Elustondo
Michael W. Lawlor

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593193

445 views

Brief Research Report

Published on 20 Mar 2025

Targeting CCRL2 enhances therapeutic outcomes in a tuberculosis mouse model

in Vaccines and Molecular Therapeutics

Tianyin Wang
Darla Quijada
Taha Ahmedna
Jennie Ruelas Castillo
Nour Sabiha Naji
J David Peske
Petros C. Karakousis
Suman Paul
Theodoros Karantanos
Styliani Karanika

Frontiers in Immunology

doi 10.3389/fimmu.2025.1501329

839 views

Original Research

Published on 20 Mar 2025

Evaluation of safety, immunogenicity, and efficacy of inactivated reverse-genetics-based H5N8 highly pathogenic avian influenza virus vaccine with various adjuvants via parenteral and mucosal routes in chickens

in Vaccines and Molecular Therapeutics

Kairat Tabynov
Aidana Kuanyshbek
Leila Yelchibayeva
Kuantay Zharmambet
Zauresh Zhumadilova
Gleb Fomin
Nikolai Petrovsky
Olaitan C. Shekoni
Gourapura J. Renukaradhya
Kaissar Tabynov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1539492

1,084 views

Original Research

Published on 20 Mar 2025

The first WHO reference panel for Infliximab anti-drug antibodies: a step towards harmonizing therapeutic drug monitoring

in Vaccines and Molecular Therapeutics

Meenu Wadhwa
Isabelle Cludts
Eleanor Atkinson
Peter Rigsby

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550655

420 views

Clinical Trial

Published on 20 Mar 2025

Safety and immunogenicity of GamEvac-Combi, a heterologous rVSV- and rAd5-vectored Ebola vaccine: a randomized controlled multicenter clinical trial in the Republic of Guinea and Russia

in Vaccines and Molecular Therapeutics

Denis Y. Logunov
Inna V. Dolzhikova
Mamadou Y. Boiro
Anna V. Kovyrshina
Alina S. Dzharullaeva
Alina S. Erokhova
Daria M. Grousova
Amir I. Tukhvatulin
Fatima M. Izhaeva
Yana V. Simakova

Frontiers in Immunology

doi 10.3389/fimmu.2025.1487039

495 views

Original Research

Accepted on 17 Mar 2025

Optimisation of the Cultured ELISpot / Fluorospot technique for the selective investigation of SARS-CoV-2 reactive central memory T-cells

in Vaccines and Molecular Therapeutics

Jack Jerome
Kirsty Wilson
Joshuah Fialho
Georgia Goodchild
Monica Devi Prakash
Charlie Mcleod
Peter C Richmond
Vasso Apostolopoulos
Katie Louise Flanagan
Magdalena Plebanski

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547220

238 views

Original Research

Published on 17 Mar 2025

Evaluation of dual pathogen recognition receptor agonists as adjuvants for respiratory syncytial virus - virus-like particles for pulmonary delivery

in Vaccines and Molecular Therapeutics

Ahmedali S. Mandviwala
Komal Liman
Anke L. W. Huckriede
Vidya A. Arankalle
Harshad P. Patil

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561297

886 views