Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Published on 03 Apr 2025

Development of a multi-epitope vaccine from outer membrane proteins and identification of novel drug targets against Francisella tularensis: an In Silico approach

in Vaccines and Molecular Therapeutics

Safoura Moradkasani
Saber Esmaeili
Mohammad Reza Asadi Karam
Ehsan Mostafavi
Behzad Shahbazi
Amir Salek Farrokhi
Mohsen Chiani
Farzad Badmasti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1479862

Perspective

Published on 03 Apr 2025

Monitoring immunological COVID-19 vaccine clinical testing across the CEPI Centralized Laboratory Network

in Vaccines and Molecular Therapeutics

Lauren M. Schwartz
Jose Vila-Belda
Jerome Carless
Sadish Dhakal
Koen Hostyn
Trina Gorman
Deborah Ogbeni
Gathoni Kamuyu
Mark Manak
Valentina Bernasconi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569251

Review

Published on 02 Apr 2025

Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases

in Vaccines and Molecular Therapeutics

Haibin Shen
Jie Chen
Meijin Liu
Minghong Zhao
Die Hu
Fangfang Xie
Qing Jin
Dewang Xiao
Zongbo Peng
Tao Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1496304

167 views

Correction

Accepted on 01 Apr 2025

Corrigendum: Adeno-Associated Virus as an Effective Malaria Booster Vaccine following Adenovirus Priming

in Vaccines and Molecular Therapeutics

Yenni Yusuf
Tatsuya Yoshii
Mitsuhiro Iyori
Kunitaka Yoshida
Hiroaki Mizukami
Shinya Fukumoto
Asrar Alam
Talha Bin Emran
Fitri Amelia
Ashekul Islam

Frontiers in Immunology

doi 10.3389/fimmu.2025.1592118

Original Research

Accepted on 01 Apr 2025

Regulatory cytokines modulate early isotype-specific response associated with COVID-19 survival

in Vaccines and Molecular Therapeutics

Sebastián Castro-Trujillo
Juanita Castro-Meneses
María Clemencia Rojas
Marcela Castro- Amaya
Giovani Lastra
Carlos Fernando Narváez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1543626

Systematic Review

Accepted on 31 Mar 2025

Effectiveness of nirsevimab immunization against RSV infection in preterm infants: a systematic review and meta-analysis Author name

in Vaccines and Molecular Therapeutics

Xiaopeng Wang
Kong Li
Xueou Liu
Panpan Wu
Lulu Zhang
Fangrui Ding

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581970

808 views

Original Research

Accepted on 31 Mar 2025

Heterologous prime-boost Zika virus vaccination induces a comprehensive humoral and cellular immunity in mouse models

in Vaccines and Molecular Therapeutics

Giuditta De Lorenzo
Rapeepat Tandavanitj
Lorena Preciado-Llanes
Ricardo Sanchez-Velazquez
Raissa Prado Rocha
Young Chan Kim
Arturo Reyes- Sandoval
Arvind H Patel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1578427

Original Research

Published on 31 Mar 2025

Design and development of highly conserved, HLA-promiscuous T cell multiepitope vaccines against human visceral leishmaniasis

in Vaccines and Molecular Therapeutics

Aline Silva Barreto
Mariana Nobre Farias de Franca
Tatiana Leão dos Santos dos Reis
Joao Antonio Barbosa Martins Silva
Priscila Lima Dos Santos
Fabrícia Alvisi de Oliveira
Angela Maria da Silva
Lucas Sousa Magalhaes
Danielle Angst Secco
Maria Aiza Fontes Andrade

Frontiers in Immunology

doi 10.3389/fimmu.2025.1540537

248 views

Original Research

Published on 31 Mar 2025

Bivalent circular RNA vaccines against porcine epidemic diarrhea virus and transmissible gastroenteritis virus

in Vaccines and Molecular Therapeutics

Weibing Zhang
Lei Wang
Liyu Chu
Xu Ma
Wenjing Gao
Yarong Wu
Yongfeng Qiao
Xianjun Wang
Lu Zhao
Hong Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1562865

319 views

Original Research

Accepted on 28 Mar 2025

Transcriptomic analysis after SARS-CoV-2 mRNA vaccination reveals a specific gene signature in low-responder hemodialysis patients Authors

in Vaccines and Molecular Therapeutics

Simone Lucchesi
Giorgio Montesi
Jacopo Polvere
Fabio Fiorino
Gabiria Pastore
Margherita Sambo
Marialetizia Lusini
Francesca Montagnani
Annalisa Ciabattini
Francesco Santoro

Frontiers in Immunology

doi 10.3389/fimmu.2025.1508659

192 views

Original Research

Accepted on 28 Mar 2025

Spatial Visualization Provides Insight into Immune Modulation by an L-DBF Vaccine Formulation Against Shigella

in Vaccines and Molecular Therapeutics

Ti Lu
Skyler T Kramer
Mary A York
Mst Nusrat Zahan
Debaki R Howlader
Zackary K Dietz
Sean K Whittier
Nathan J Bivens
Alexander Jurkevich
Lyndon Coghill

Frontiers in Immunology

doi 10.3389/fimmu.2025.1577040

Original Research

Published on 28 Mar 2025

Design of a peptide-based vaccine against human respiratory syncytial virus using a reverse vaccinology approach: evaluation of immunogenicity, antigenicity, allergenicity, and toxicity

in Vaccines and Molecular Therapeutics

Hadeel Alnajran
Maaweya Awadalla
Fahad M. Aldakheel
Intikhab Alam
Afaque A. Momin
Wael Alturaiki
Bandar Alosaimi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1546254

564 views

Original Research

Published on 28 Mar 2025

Beyond interferon gamma - decreased cellular response to COVID-19 vaccination booster in patients with autoimmune inflammatory rheumatic diseases

in Vaccines and Molecular Therapeutics

Jakub Wroński
Magdalena Massalska
Bożena Jaszczyk
Anna Felis-Giemza
Anna Kornatka
Magdalena Plebańczyk
Tomasz Burakowski
Brygida Kwiatkowska
Ewa Kuca-Warnawin
Marzena Ciechomska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1568439

369 views

Original Research

Published on 27 Mar 2025

Chimeric receptor-binding domain vaccine design and sequential immunization enhanced broadly neutralizing antibody responses against COVID-19

in Vaccines and Molecular Therapeutics

Xiao Yang
Xin Tang
Ying Sun
Hualong Xi
Wei Peng
Lu Yan
Wenjing Teng
Yang Zang
Chunlai Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1543212

322 views

Original Research

Published on 27 Mar 2025

Longitudinal cellular and humoral immune responses following COVID-19 BNT162b2-mRNA-based booster vaccination of craft and manual workers in Qatar

in Vaccines and Molecular Therapeutics

Remy Thomas
Ahmed Zaqout
Bakhita Meqbel
Umar Jafar
Nishant N. Vaikath
Abdullah Aldushain
Adviti Naik
Hibah Shaath
Neyla S. Al-Akl
Abdi Adam

Frontiers in Immunology

doi 10.3389/fimmu.2025.1557426

335 views

Original Research

Published on 27 Mar 2025

Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters

in Vaccines and Molecular Therapeutics

Jessica I. Ahmed
Samantha J. Krosta
Mandy N. Reimer
Winnie Cheung
Christine Mesa
Carmen Lopez
Rayeil J. Chua
Farah Alsattari
Alyssia Robinson
Kathy Manguiat

Frontiers in Immunology

doi 10.3389/fimmu.2025.1529134

420 views