Frontiers in Immunology | T Cell Biology

Original Research

Published on 18 Mar 2025

Functional insights of an uncommon hypomorphic variant in IL2RG as a monogenic cause of CVID-like disease with antibody deficiency and T CD4 lymphopenia

in T Cell Biology

Andrea González-Torbay
Keren Reche-Yebra
Álvaro Clemente-Bernal
Yolanda Soto Serrano
Luz Yadira Bravo-Gallego
Almudena Fernández López
Rebeca Rodríguez-Pena
María Bravo García-Morato
Eduardo López-Granados
Lucía del Pino-Molina

Frontiers in Immunology

doi 10.3389/fimmu.2025.1544863

561 views

Original Research

Published on 18 Mar 2025

Increased long-term central memory T cells in patients with retreatment pulmonary tuberculosis

in T Cell Biology

Xin Yao
Haomin Cai
Jianxia Chen
Fangyong Yu
Xiaocui Wu
Yarong Shi
Yang Hu
Yuyan Xu
Qinghua Xu
Zhonghua Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1545537

322 views

Original Research

Published on 18 Mar 2025

Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients

in T Cell Biology

Chanchan Xiao
Jian Xiang
Haoyun Wang
Wen Gao
Tianchan Peng
Shumin Li
Jun Su
Xi Chen
Lijuan Gao
Ruohu Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534530

385 views

Original Research

Accepted on 14 Mar 2025

HnRNP L is essential for peripheral T cell proliferation and survival

in T Cell Biology

Tristan L A White
Devin J Henry
Sean D A Roberts
Ye Jin
Yinan Gong
Penelope Anne Morel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1543145

Brief Research Report

Published on 14 Mar 2025

A pooled CRISPR screen identifies the Tα2 enhancer element as a driver of TRA expression in a subset of mature human T lymphocytes

in T Cell Biology

Pascal Y. Schönberg
Ángela Muñoz-Ovalle
Maciej Paszkowski-Rogacz
Eugenia Crespo
Duran Sürün
Anja Feldmann
Frank Buchholz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1536003

620 views

Review

Published on 06 Mar 2025

The dual role of tissue regulatory T cells in tissue repair: return to homeostasis or fibrosis

in T Cell Biology

Peiyan Zhang
Jiawei Wang
Jinlin Miao
Ping Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560578

639 views

Review

Published on 04 Mar 2025

Advance in chimeric antigen receptor T therapy in autoimmune diseases

in T Cell Biology

Xiaolan Ji
Yunfan Sun
Yuyang Xie
Jianling Gao
Ji Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533254

954 views

Original Research

Published on 03 Mar 2025

A backbone-based flow cytometry approach to decipher regulatory T cell trajectories in the human thymus

in T Cell Biology

Beatriz Moleirinho
Margarida Paulo-Pedro
Nicole C. Martins
Emily Jelagat
Eller Conti
Tiago R. Velho
Miguel Abecasis
Rui Anjos
Afonso R. M. Almeida
Ana E. Sousa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1553535

1,351 views

Correction

Published on 27 Feb 2025

Corrigendum: State of play in the molecular presentation and recognition of anti-tumor lipid-based analogues

in T Cell Biology

T. Praveena
Jérôme Le Nours

Frontiers in Immunology

doi 10.3389/fimmu.2025.1574591

278 views

Original Research

Published on 26 Feb 2025

Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers

in T Cell Biology

Vasileios Kyttaris
Daniel J. Wallace
Arezou Khosroshahi
Andrew Concoff
Nicole Wilson
Chau Ching Liu
Susan Manzi
Joseph Ahearn
Sepehr Taghavi
Touba Warsi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1518208

2,422 views

Review

Published on 26 Feb 2025

The clinical significance of T-cell regulation in hypertension treatment

in T Cell Biology

Miaoxin Fu
Mingzhu Lv
Jinyue Guo
Aihua Mei
Hang Qian
Handong Yang
Wenwen Wu
Zhixin Liu
Jixin Zhong
Ying Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550206

926 views

Brief Research Report

Published on 25 Feb 2025

Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans

in T Cell Biology

Yumi Tamura
Shun Ohki
Haruna Nagai
Rin Yoshizato
Shizuki Nishi
Yuqi Jin
Yasuo Kitajima
Yun Guo
Tatsuo Ichinohe
Satoshi Okada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560383

1,164 views

Review

Published on 19 Feb 2025

Neural regulation of the thymus: past, current, and future perspectives

in T Cell Biology

Randall S. Carpenter
Maria K. Lagou
George S. Karagiannis
Maria Maryanovich

Frontiers in Immunology

doi 10.3389/fimmu.2025.1552979

1,081 views

Editorial

Published on 18 Feb 2025

Editorial: Current insights in cancer metabolism and T cell based tumor immunity

in T Cell Biology

Takashi MaruYama
Takashi Tanikawa
Jian Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1566491

489 views

Original Research

Published on 18 Feb 2025

Recognition of MR1-antigen complexes by TCR Vγ9Vδ2

in T Cell Biology

José Pedro Loureiro
Alessandro Vacchini
Giuliano Berloffa
Jan Devan
Verena Schaefer
Vladimir Nosi
Rodrigo Colombo
Aisha Beshirova
Giulia Montanelli
Benedikt Meyer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1519128

1,185 views

Original Research

Published on 17 Feb 2025

Use of a universal targeting CAR T cell to simultaneously kill cancer cells and cancer-associated fibroblasts

in T Cell Biology

Bo Huang
Suilan Zheng
Kasireddy Sudarshan
Ramesh Mukkamala
Madduri Srinivasarao
Tushar Sardesai
Xiaofei Yang
Haiyan Chu
Philip S. Low

Frontiers in Immunology

doi 10.3389/fimmu.2025.1539265

1,615 views