Frontiers in Immunology | T Cell Biology

Original Research

Published on 03 Mar 2025

A backbone-based flow cytometry approach to decipher regulatory T cell trajectories in the human thymus

in T Cell Biology

Beatriz Moleirinho
Margarida Paulo-Pedro
Nicole C. Martins
Emily Jelagat
Eller Conti
Tiago R. Velho
Miguel Abecasis
Rui Anjos
Afonso R. M. Almeida
Ana E. Sousa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1553535

196 views

Correction

Published on 27 Feb 2025

Corrigendum: State of play in the molecular presentation and recognition of anti-tumor lipid-based analogues

in T Cell Biology

T. Praveena
Jérôme Le Nours

Frontiers in Immunology

doi 10.3389/fimmu.2025.1574591

Original Research

Accepted on 26 Feb 2025

Characterizing HLA-A2-Restricted CD8 + T-cell Epitopes and Immune Responses to Omicron Variants in SARS-CoV-2-Inactivated Vaccine Recipients

in T Cell Biology

Chanchan Xiao
Jan jian Xiang
Tianchan Peng
Wen Gao
Shumin Li
Jun Su
Lijuan Gao
Ruohu Shi
Xinyi Mou
Jun Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534530

Original Research

Published on 26 Feb 2025

Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers

in T Cell Biology

Vasileios Kyttaris
Daniel J. Wallace
Arezou Khosroshahi
Andrew Concoff
Nicole Wilson
Chau Ching Liu
Susan Manzi
Joseph Ahearn
Sepehr Taghavi
Touba Warsi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1518208

717 views

Review

Published on 26 Feb 2025

The clinical significance of T-cell regulation in hypertension treatment

in T Cell Biology

Miaoxin Fu
Mingzhu Lv
Jinyue Guo
Aihua Mei
Hang Qian
Handong Yang
Wenwen Wu
Zhixin Liu
Jixin Zhong
Ying Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550206

212 views

Original Research

Accepted on 25 Feb 2025

Functional insights of an uncommon hypomorphic variant in IL2RG as a monogenic cause of CVID-like disease with antibody deficiency and T CD4 lymphopenia

in T Cell Biology

Andrea González-Torbay
Keren Reche Yebra
Álvaro Clemente Bernal
Yolanda Soto Serrano
Yadira Bravo Gallego
María Bravo García-Morato
Eduardo Lopez-Granados
Lucía Del Pino Molina

Frontiers in Immunology

doi 10.3389/fimmu.2025.1544863

Brief Research Report

Published on 25 Feb 2025

Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans

in T Cell Biology

Yumi Tamura
Shun Ohki
Haruna Nagai
Rin Yoshizato
Shizuki Nishi
Yuqi Jin
Yasuo Kitajima
Yun Guo
Tatsuo Ichinohe
Satoshi Okada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560383

222 views

Original Research

Accepted on 24 Feb 2025

Screening and Mechanistic Study of Natural Compounds that Enhance T Cell Anti-Tumor Effects Post-Heat Treatment

in T Cell Biology

Zhaoyi Wang
Zhongqi Diao
Yiyan Zhang
jiangying Liu
yeshan Li
Zijin Sun
Huimin Zhen
Haojia Wang
Siyun Yang
Tieshan Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1537398

Original Research

Accepted on 21 Feb 2025

Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor

in T Cell Biology

Richard John Suckling
Cevriye Pamukcu
Robert Alan Simmons
Daniel Fonseca
Saher Shaikh
Rahul Khanolkar
Hemza Ghadbane
Thomas Gligoris
Marco Lepore
Vijaykumar Karuppiah

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547664

Original Research

Accepted on 21 Feb 2025

Repertoire-based mapping and time-tracking of helper T cell subsets in scRNA-Seq

in T Cell Biology

Dmitry M Chudakov
Daniil K Lukyanov
Valeriia Kriukova
Krisitin Ladell
Irina Shagina
Dmitry Staroverov
Bella E Minasian
Anna S Fedosova
Pavel Shelyakin
Oleg N Suchalko

Frontiers in Immunology

doi 10.3389/fimmu.2025.1536302

Review

Published on 19 Feb 2025

Neural regulation of the thymus: past, current, and future perspectives

in T Cell Biology

Randall S. Carpenter
Maria K. Lagou
George S. Karagiannis
Maria Maryanovich

Frontiers in Immunology

doi 10.3389/fimmu.2025.1552979

233 views

Original Research

Accepted on 18 Feb 2025

Increased long-term central memory T cells (T CM ) in patients with retreatment pulmonary tuberculosis

in T Cell Biology

Xin Yao
Haomin Cai
Xiong Chen
Fangyou Yu
Xiaocui Wu
Lulu Chen
Yarong Shi
Yang Hu
Yuyan Xu
Zhonghua Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1545537

Review

Accepted on 18 Feb 2025

The dual role of tissue regulatory T cells in tissue repair: Return to homeostasis or fibrosis

in T Cell Biology

Peiyan Zhang
Jiawei Wang
Jinlin Miao
Ping Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560578

Editorial

Published on 18 Feb 2025

Editorial: Current insights in cancer metabolism and T cell based tumor immunity

in T Cell Biology

Takashi MaruYama
Takashi Tanikawa
Jian Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1566491

243 views

Original Research

Published on 18 Feb 2025

Recognition of MR1-antigen complexes by TCR Vγ9Vδ2

in T Cell Biology

José Pedro Loureiro
Alessandro Vacchini
Giuliano Berloffa
Jan Devan
Verena Schaefer
Vladimir Nosi
Rodrigo Colombo
Aisha Beshirova
Giulia Montanelli
Benedikt Meyer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1519128

529 views

Brief Research Report

Accepted on 17 Feb 2025

A Pooled CRISPR Screen identifies the Ta2 enhancer element as a driver of TRA expression in a subset of mature human T lymphocytes

in T Cell Biology

Pascal Yves Schönberg
Ángela Muñoz-Ovalle
Maciej Paszkowski-Rogacz
Eugenia Crespo
Duran Sürün
Anja Feldmann
Frank Buchholz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1536003

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Articles

A backbone-based flow cytometry approach to decipher regulatory T cell trajectories in the human thymus

Corrigendum: State of play in the molecular presentation and recognition of anti-tumor lipid-based analogues

Characterizing HLA-A2-Restricted CD8 + T-cell Epitopes and Immune Responses to Omicron Variants in SARS-CoV-2-Inactivated Vaccine Recipients

Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers

The clinical significance of T-cell regulation in hypertension treatment

Functional insights of an uncommon hypomorphic variant in IL2RG as a monogenic cause of CVID-like disease with antibody deficiency and T CD4 lymphopenia

Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans

Screening and Mechanistic Study of Natural Compounds that Enhance T Cell Anti-Tumor Effects Post-Heat Treatment

Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor

Repertoire-based mapping and time-tracking of helper T cell subsets in scRNA-Seq

Neural regulation of the thymus: past, current, and future perspectives

Increased long-term central memory T cells (T CM ) in patients with retreatment pulmonary tuberculosis

The dual role of tissue regulatory T cells in tissue repair: Return to homeostasis or fibrosis

Editorial: Current insights in cancer metabolism and T cell based tumor immunity

Recognition of MR1-antigen complexes by TCR Vγ9Vδ2

A Pooled CRISPR Screen identifies the Ta2 enhancer element as a driver of TRA expression in a subset of mature human T lymphocytes