Frontiers in Immunology | Systems Immunology

Original Research

Published on 14 Jul 2025

Exploration of differential expression and biological significance of amino acid metabolism genes in osteoarthritis

in Systems Immunology

Zhenghuan Zhu
Jiaqing Meng
Junfeng Hu
Lingmin Hu
Wenge Ding
Wanchao Zhang
Chuang Zhao
Lin Feng
Kejie Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1588072

185 views

Review

Published on 11 Jul 2025

Advanced omics approaches in liver transplant settings: current applications and future prospectives

in Systems Immunology

Huijuan Wang
Yifeng Zhou
Lu Yu
Zhengtao Liu
Shusen Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1564248

437 views

Original Research

Published on 11 Jul 2025

Leveraging the integration of bioinformatics and machine learning to uncover common biomarkers and molecular pathways underlying diabetes and nephrolithiasis

in Systems Immunology

Xudong Shen
Guoxiang Li
Junfeng Yao
Junping Yang
Xiaobo Ding
Zongyao Hao
Yan Chen
Yang Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1574157

350 views

Original Research

Accepted on 10 Jul 2025

An explorable model of an adverse outcome pathway of cytokine release syndrome related to the administration of immunomodulatory biotherapeutics and cellular therapies

in Systems Immunology

Alexander Mazein
Oxana Lopata
Kristin Reiche
Katherina Sewald
Miriam Alb
Christina Sakellariou
Patricia Gogesch
Hannah Morgan
Vanessa Neuhaus
Nhu-Nguyen Pham

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601670

193 views

Original Research

Accepted on 09 Jul 2025

Antimicrobial and Immunomodulatory Activity of Natural Bioactive Compounds -an in vitro Investigation with Potential Applications in Managing Hidradenitis Suppurativa

in Systems Immunology

Valentina Alexandra Bădăluță
Adrian Ionascu
Lia-Mara Ditu
Curutiu Carmen
Alina Maria Holban
Eliza Oprea
Yiannis Kourkoutas
Mara Madalina Mihai
Corina Ioana Cucu
Ariana Hudita

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608269

177 views

Review

Accepted on 08 Jul 2025

Considering Local Immunity for Innovative Immunomodulatory Approaches: Pulmonary Sepsis as a use case

in Systems Immunology

Emilie Vernay
Elisabeth Cerrato
François Santinon
Céline Monard
Pauline Perez
Florence Allantaz
Anne-Claire Lukaszewicz
Jean-François Llitjos

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627313

197 views

Original Research

Accepted on 08 Jul 2025

A Comprehensive Bioinformatics Analysis of Pathways and Biomarkers Shared Between Type 2 Diabetes Mellitus and Chronic Obstructive Pulmonary Disease

in Systems Immunology

Tingting Hu
Xiaomei Duan
Jiale Gao
Zheng Li
Dan Xu
Jing Jing
Fengsen Li
Jianbing Ding
Li Ma
Min Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1536551

593 views

Original Research

Published on 08 Jul 2025

Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors—a network meta-analysis

in Systems Immunology

Monika Golinska
Aleksander Rycerz
Matylda Sobczak
Jedrzej Chrzanowski
Konrad Stawiski
Wojciech Fendler

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619434

412 views

Correction

Published on 08 Jul 2025

Corrigendum: Mapping knowledge structure and research of the biologic treatment of asthma: a bibliometric study

in Systems Immunology

Jiamin Sun
Shiyao Bai
Jieyu Zhao
Danling Li
Xueqing Ma
Lin Ma
Xinming Su

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630817

174 views

Original Research

Accepted on 07 Jul 2025

Decoupled Dynamics of Absolute and Relative Lymphocyte Counts and Age-Polarized CD4 + /CD8 + Ratio in Infants versus Older Adults

in Systems Immunology

Jianchun Yu
Ting Ge
Guixin He
Qian Cui
Shuangcui Wang
Zekun Wang
Yingying Xie
Yuanyuan Tian
Juyue Zhou
Wentao Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599515

160 views

Review

Accepted on 07 Jul 2025

Emerging IO checkpoints in gastrointestinal oncology

in Systems Immunology

Alireza Tojjari
Anwaar Saeed
Ludimila Cavalcante

Frontiers in Immunology

doi 10.3389/fimmu.2025.1575713

139 views

Original Research

Accepted on 03 Jul 2025

Comprehensive characterization of multi-omics landscapes between gut microbial metabolites and the druggable genome in sepsis

in Systems Immunology

Jun Liu
Tong Li
Li Xing
Xingyu Li
Jianbo Zhang
Peng Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597676

140 views

Original Research

Published on 03 Jul 2025

CD79A and GADD45A as novel immune-related biomarkers for respiratory syncytial virus severity in children: an integrated machine learning analysis and clinical validation

in Systems Immunology

Juan Juan Chen
Zhang Ze Lu
Yu Xin Jing
Xing Mei Nong
Yi Qin
Jin Yang Huang
Na Lin
Jie Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609183

519 views

Original Research

Accepted on 02 Jul 2025

Role of hypoxia-related genes and immune infiltration in intervertebral disc degeneration: molecular mechanisms and diagnostic potential

in Systems Immunology

Kai Zhou
Jiaxiang Zhou
XianJin Luo
Yan Chen
Jian Ao
Wei Wu
Bo Yang
Zhongyuan He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1606905

100 views

Original Research

Published on 02 Jul 2025

Identification and validation of glycosylation-related gene signatures for prognostic stratification in sepsis

in Systems Immunology

Chunyang Li
Haiyan Xue
Lihe Chen
Fengxue Zhu
Jie Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608082

381 views

Original Research

Published on 02 Jul 2025

Prediction and immune landscape study of potentially key autophagy-related biomarkers in preeclampsia with gestational diabetes mellitus

in Systems Immunology

Qin Wang
Xiaoqi Li
Wen Ye
Lin Lin
Kejun Ye
Mengjia Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571795

876 views