Frontiers in Immunology | Systems Immunology

Original Research

Published on 02 Feb 2024

MIHIC: a multiplex IHC histopathological image classification dataset for lung cancer immune microenvironment quantification

in Systems Immunology

Ranran Wang
Yusong Qiu
Tong Wang
Mingkang Wang
Shan Jin
Fengyu Cong
Yong Zhang
Hongming Xu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1334348

8,512 views
7 citations

Original Research

Published on 01 Feb 2024

Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma

in Systems Immunology

Julia Femel
Cameron Hill
Irineu Illa Bochaca
Jamie L. Booth
Tina G. Asnaashari
Maria M. Steele
Ata S. Moshiri
Hyungrok Do
Judy Zhong
Iman Osman

Frontiers in Immunology

doi 10.3389/fimmu.2024.1328602

7,064 views
3 citations

Original Research

Published on 29 Jan 2024

An in silico modeling approach to understanding the dynamics of the post-burn immune response

in Systems Immunology

H. Ibrahim Korkmaz
Vivek M. Sheraton
Roland V. Bumbuc
Meifang Li
Anouk Pijpe
Patrick P. G. Mulder
Bouke K. H. L. Boekema
Evelien de Jong
Stephan G. F. Papendorp
Ruud Brands

Frontiers in Immunology

doi 10.3389/fimmu.2024.1303776

4,224 views
4 citations

Original Research

Published on 25 Jan 2024

Elucidating common pathogenic transcriptional networks in infective endocarditis and sepsis: integrated insights from biomarker discovery and single-cell RNA sequencing

in Systems Immunology

Chen Yi
Haoxiang Zhang
Jun Yang
Dongjuan Chen
Shaofeng Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2023.1298041

4,878 views
5 citations

Original Research

Published on 23 Jan 2024

Evidence of collective influence in innate sensing using fluidic force microscopy

in Systems Immunology

Elizabeth J. Mulder
Brittany Moser
Jennifer Delgado
Rachel C. Steinhardt
Aaron P. Esser-Kahn

Frontiers in Immunology

doi 10.3389/fimmu.2024.1340384

2,364 views
2 citations

Original Research

Published on 22 Jan 2024

Highly heterogenous humoral immune response in Lyme disease patients revealed by broad machine learning-assisted antibody binding profiling with random peptide arrays

in Systems Immunology

L. Kelbauskas
J. B. Legutki
N. W. Woodbury

Frontiers in Immunology

doi 10.3389/fimmu.2024.1335446

3,853 views
4 citations

Original Research

Published on 11 Jan 2024

Bioinformatic analysis of related immune cell infiltration and key genes in the progression of osteonecrosis of the femoral head

in Systems Immunology

Xudong Duan
Fangze Xing
Jiewen Zhang
Heng Li
Yang Chen
Yutian Lei
Yiwei Zhao
Ruomu Cao
Huanshuai Guan
Ning Kong

Frontiers in Immunology

doi 10.3389/fimmu.2023.1340446

7,131 views
14 citations

Review

Published on 11 Jan 2024

Ceramide on the road to insulin resistance and immunometabolic disorders in transition dairy cows: driver or passenger?

in Systems Immunology

Yuchao Zhao
Huiying Zhao
Liuxue Li
Shiqing Yu
Ming Liu
Linshu Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2023.1321597

5,460 views
5 citations

Original Research

Published on 11 Jan 2024

Comprehensive analysis of an endoplasmic reticulum stress-related gene prediction model and immune infiltration in idiopathic pulmonary fibrosis

in Systems Immunology

Honglan Zhu
Aiming Zhou
Menglin Zhang
Lin Pan
Xiao Wu
Chenkun Fu
Ling Gong
Wenting Yang
Daishun Liu
Yiju Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2023.1305025

4,291 views
8 citations

Original Research

Published on 10 Jan 2024

Identification and validation of platelet-related diagnostic markers and potential drug screening in ischemic stroke by integrating comprehensive bioinformatics analysis and machine learning

in Systems Immunology

Yifei Geng
Yuchen Liu
Min Wang
Xi Dong
Xiao Sun
Yun Luo
Xiaobo Sun

Frontiers in Immunology

doi 10.3389/fimmu.2023.1320475

6,352 views
1 citation

Original Research

Published on 08 Jan 2024

Integrative analysis of potential diagnostic markers and therapeutic targets for glomerulus-associated diabetic nephropathy based on cellular senescence

in Systems Immunology

Donglin Sun
Shuqi Wei
Dandan Wang
Min Zeng
Yihao Mo
Huafeng Li
Caixing Liang
Lu Li
Jun Wei Zhang
Li Wang

Frontiers in Immunology

doi 10.3389/fimmu.2023.1328757

8,656 views
7 citations

Original Research

Published on 08 Jan 2024

HOXA3 functions as the on-off switch to regulate the development of hESC-derived third pharyngeal pouch endoderm through EPHB2-mediated Wnt pathway

in Systems Immunology

Yingjie Fu
Xueyan Zhang
Haibin Wu
Pingping Zhang
Shoupei Liu
Tingting Guo
Huanhuan Shan
Yan Liang
Honglin Chen
Jinghe Xie

Frontiers in Immunology

doi 10.3389/fimmu.2023.1258074

4,603 views
6 citations

Original Research

Published on 04 Jan 2024

Prediction of six macrophage phenotypes and their IL-10 content based on single-cell morphology using artificial intelligence

in Systems Immunology

Mischa Selig
Logan Poehlman
Nils C. Lang
Marita Völker
Bernd Rolauffs
Melanie L. Hart

Frontiers in Immunology

doi 10.3389/fimmu.2023.1336393

7,733 views
22 citations

Original Research

Published on 02 Jan 2024

A comprehensive battery of flow cytometric immunoassays for the in vitro testing of chemical effects in human blood cells

in Systems Immunology

Arkadiusz Pierzchalski
Ana C. Zenclussen
Gunda Herberth

Frontiers in Immunology

doi 10.3389/fimmu.2023.1327960

7,400 views
9 citations

Original Research

Published on 21 Dec 2023

Causal effects and immune cell mediators between prescription analgesic use and risk of infectious diseases: a Mendelian randomization study

in Systems Immunology

Yi Jin
Xinghao Yu
Jun Li
Mingzhu Su
Xiaomin Li

Frontiers in Immunology

doi 10.3389/fimmu.2023.1319127

7,548 views
9 citations

Original Research

Published on 20 Dec 2023

Multi-omics computational analysis unveils the involvement of AP-1 and CTCF in hysteresis of chromatin states during macrophage polarization

in Systems Immunology

Yubo Zhang
Wenbo Yang
Yutaro Kumagai
Martin Loza
Weihang Zhang
Sung-Joon Park
Kenta Nakai

Frontiers in Immunology

doi 10.3389/fimmu.2023.1304778

10,385 views
5 citations

Original Research

Published on 15 Dec 2023

New insights from integrated bioinformatics analysis: the role of circadian rhythm disruption and immune infiltration in obstructive sleep apnea disease

in Systems Immunology

Xinyue Zhang
Yixuan Wang
Zhou Pan
Ke Hu

Frontiers in Immunology

doi 10.3389/fimmu.2023.1273114

3,969 views
3 citations

Original Research

Published on 14 Dec 2023

KLF17 is an important regulatory component of the transcriptomic response of Atlantic salmon macrophages to Piscirickettsia salmonis infection

in Systems Immunology

Diego Pérez-Stuardo
Mateus Frazão
Valentina Ibaceta
Bernardo Brianson
Evelyn Sánchez
J. Andrés Rivas-Pardo
Eva Vallejos-Vidal
Felipe E. Reyes-López
Daniela Toro-Ascuy
Elena A. Vidal

Frontiers in Immunology

doi 10.3389/fimmu.2023.1264599

3,935 views
5 citations

Original Research

Published on 08 Dec 2023

PANDORA v2.0: Benchmarking peptide-MHC II models and software improvements

in Systems Immunology

Farzaneh M. Parizi
Dario F. Marzella
Gayatri Ramakrishnan
Peter A. C. ‘t Hoen
Mohammad Hossein Karimi-Jafari
Li C. Xue

Frontiers in Immunology

doi 10.3389/fimmu.2023.1285899

5,750 views
14 citations

Original Research

Published on 04 Dec 2023

Deciphering the rule of antigen-antibody amino acid interaction

in Systems Immunology

Min Jiang
Changyin Fang
Yongping Ma

Frontiers in Immunology

doi 10.3389/fimmu.2023.1269916

4,137 views
4 citations

Original Research

Published on 28 Nov 2023

The Simple prEservatioN of Single cElls method for cryopreservation enables the generation of single-cell immune profiles from whole blood

in Systems Immunology

Sarthak Satpathy
Beena E. Thomas
William J. Pilcher
Mojtaba Bakhtiari
Lori A. Ponder
Rafal Pacholczyk
Sampath Prahalad
Swati S. Bhasin
David H. Munn
Manoj K. Bhasin

Frontiers in Immunology

doi 10.3389/fimmu.2023.1271800

6,997 views
11 citations

Original Research

Published on 28 Nov 2023

Genomic annotation for vaccine target identification and immunoinformatics-guided multi-epitope-based vaccine design against Songling virus through screening its whole genome encoded proteins

in Systems Immunology

S. Luqman Ali
Awais Ali
Abdulaziz Alamri
Aliya Baiduissenova
Marat Dusmagambetov
Aigul Abduldayeva

Frontiers in Immunology

doi 10.3389/fimmu.2023.1284366

4,909 views
24 citations

Original Research

Published on 20 Nov 2023

Identification of drug candidates targeting monocyte reprogramming in people living with HIV

in Systems Immunology

Rainer Knoll
Lorenzo Bonaguro
Jéssica C. dos Santos
Stefanie Warnat-Herresthal
Maartje C. P. Jacobs-Cleophas
Edda Blümel
Nico Reusch
Arik Horne
Miriam Herbert
Melanie Nuesch-Germano

Frontiers in Immunology

doi 10.3389/fimmu.2023.1275136

27,036 views
11 citations

Original Research

Published on 16 Nov 2023

Unraveling immunotherapeutic targets for endometriosis: a transcriptomic and single-cell analysis

in Systems Immunology

Cankun Zhou
Minqing Feng
Yonglian Chen
Side Lv
Yifan Zhang
Jiebo Chen
Rujian Zhang
Xiaobin Huang

Frontiers in Immunology

doi 10.3389/fimmu.2023.1288263

12,427 views
18 citations

524 articles

articles

MIHIC: a multiplex IHC histopathological image classification dataset for lung cancer immune microenvironment quantification

Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma

An in silico modeling approach to understanding the dynamics of the post-burn immune response

Elucidating common pathogenic transcriptional networks in infective endocarditis and sepsis: integrated insights from biomarker discovery and single-cell RNA sequencing

Evidence of collective influence in innate sensing using fluidic force microscopy

Highly heterogenous humoral immune response in Lyme disease patients revealed by broad machine learning-assisted antibody binding profiling with random peptide arrays

Bioinformatic analysis of related immune cell infiltration and key genes in the progression of osteonecrosis of the femoral head

Ceramide on the road to insulin resistance and immunometabolic disorders in transition dairy cows: driver or passenger?

Comprehensive analysis of an endoplasmic reticulum stress-related gene prediction model and immune infiltration in idiopathic pulmonary fibrosis

Identification and validation of platelet-related diagnostic markers and potential drug screening in ischemic stroke by integrating comprehensive bioinformatics analysis and machine learning

Integrative analysis of potential diagnostic markers and therapeutic targets for glomerulus-associated diabetic nephropathy based on cellular senescence

HOXA3 functions as the on-off switch to regulate the development of hESC-derived third pharyngeal pouch endoderm through EPHB2-mediated Wnt pathway

Prediction of six macrophage phenotypes and their IL-10 content based on single-cell morphology using artificial intelligence

A comprehensive battery of flow cytometric immunoassays for the in vitro testing of chemical effects in human blood cells

Causal effects and immune cell mediators between prescription analgesic use and risk of infectious diseases: a Mendelian randomization study

Multi-omics computational analysis unveils the involvement of AP-1 and CTCF in hysteresis of chromatin states during macrophage polarization

New insights from integrated bioinformatics analysis: the role of circadian rhythm disruption and immune infiltration in obstructive sleep apnea disease

KLF17 is an important regulatory component of the transcriptomic response of Atlantic salmon macrophages to Piscirickettsia salmonis infection

PANDORA v2.0: Benchmarking peptide-MHC II models and software improvements

Deciphering the rule of antigen-antibody amino acid interaction

The Simple prEservatioN of Single cElls method for cryopreservation enables the generation of single-cell immune profiles from whole blood

Genomic annotation for vaccine target identification and immunoinformatics-guided multi-epitope-based vaccine design against Songling virus through screening its whole genome encoded proteins

Identification of drug candidates targeting monocyte reprogramming in people living with HIV

Unraveling immunotherapeutic targets for endometriosis: a transcriptomic and single-cell analysis