Frontiers in Immunology | Systems Immunology

Original Research

Accepted on 17 Oct 2025

Portfolio analysis of single-cell RNA-sequencing and transcriptomic data unravels immune cells and telomere-related biomarkers in sepsis

in Systems Immunology

Dan Chen
Xiyi Huang
Chun Wang
Cheng Zheng
Yunhao Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638156

Systematic Review

Published on 17 Oct 2025

Global research trends on macrophage polarization in osteoarthritis: a bibliometric analysis

in Systems Immunology

Abdulaziz S. Bamahel
Jia Liu
Zhuoyu Zhang
Yizhuo Deng
Chaoyou Xue
Xun Sun
Wei Wu
Sheng Bi
Nadeem Zubair
Guangchen Nie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659938

621 views

Original Research

Published on 17 Oct 2025

Sulfotransferase SULT2B1 contributes to the epithelial–immune microenvironment homeostasis in imiquimod-induced psoriatic dermatitis

in Systems Immunology

Kenji Morino
Sayaka Akiyoshi
Keisuke Matsubara
Yuki Sugiura
Yoshihiro Izumi
Shu Yotsumoto
Kazuhiko Yamamura
Rae Maeda
Masatomo Takahashi
Keisuke Nakata

Frontiers in Immunology

doi 10.3389/fimmu.2025.1632426

449 views

Original Research

Accepted on 16 Oct 2025

Application of the Richards function to serum antibody titration

in Systems Immunology

Ágnes Kovács
Krisztian Papp
József Prechl
Tamás Pfeil

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657633

Original Research

Published on 15 Oct 2025

Identification of hub genes in congenital hypothyroidism and construction of the associated immune regulatory network

in Systems Immunology

Mingliang Shan
Li Xu
Wenzhe Yang
Shiguo Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608098

1,153 views

Original Research

Accepted on 14 Oct 2025

Microbiomic and metabolomic analysis of the effect of heat-sensitive moxibustion on allergic rhinitis in rats

in Systems Immunology

Jun Xiong
JIanheng Li
Haiyan Xu
Yicheng Li
Lunbin Lu
Shuang Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656060

100 views

Original Research

Accepted on 14 Oct 2025

Integrative Pharmacovigilance and AI-Based Framework Uncovers Potential Drug Triggers in Juvenile Idiopathic Arthritis

in Systems Immunology

Luo Qiang
Yuxiao Chen
Dawei Liu
Xinlin Wu
Jingyi Zhao
Xuemei Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653003

143 views

Hypothesis and Theory

Accepted on 13 Oct 2025

Antibodies and cryptographic hash functions: quantifying the specificity paradox

in Systems Immunology

Robert J. Petrella

Frontiers in Immunology

doi 10.3389/fimmu.2025.1585421

Original Research

Accepted on 06 Oct 2025

Comprehensive Real-Time Metabolic Profiling of Peripheral Blood Mononuclear Cells Reveals Important Methodological Considerations for Immunometabolism Research

in Systems Immunology

Jonathan Barlow
Michael MacLeod
Fendi Pradana
Alex James Wadley

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676550

228 views

Review

Accepted on 06 Oct 2025

Immunometabolic Regulation of Disulfidptosis in Orthopedic Diseases: Mechanistic Heterogeneity and Therapeutic Targets

in Systems Immunology

Xiaoming Zhao
Shaobo Wu
Xiaochen Su
Jun Gao
Lian Qu
Yingang Zhang
Yilei Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647931

Original Research

Accepted on 06 Oct 2025

Decoding the Hypoxia-Exosome-Immune Triad in OSA: PRCP/UCHL1/BTG2-Driven Metabolic Dysregulation Revealed by Interpretable Machine Learning

in Systems Immunology

Weilong Ye
Xiaoxi Lin
Feiju Chen
Yunan Wang
Yitian Yang
Lianfang Du
Jingjing Pan
Weifeng Liao
Bainian Chen
Riken Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1587522

108 views

Original Research

Accepted on 02 Oct 2025

Integrative Multi-Omics Identifies MEIS3 as a Diagnostic Biomarker and Immune Modulator in Hypertrophic Cardiomyopathy

in Systems Immunology

jinchen he
zehua zhou
dejun kong
heng zhu
chunmei liu
yuyuan wang
tianqi wu
jinfeng chen
Yan liao
Qi Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675467

186 views

Original Research

Accepted on 02 Oct 2025

Differential Gene Expression Profiling and Machine Learning-Based Discovery of Key Genetic Markers in VTE and CKD

in Systems Immunology

Hui Li
Cai Lin
JunJie Kuang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654673

215 views

Original Research

Published on 02 Oct 2025

Artificial intelligence–driven analysis of antibody and nucleic acid biomarkers for enhanced disease diagnostics

in Systems Immunology

Zihan Liu
Feng Zhu
Mei Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633989

927 views

Original Research

Accepted on 30 Sep 2025

Membraneless organelles-based integrative analysis constructs an immune-related prognostic signature and identifies NRG1 as a novel methylation biomarker in colorectal cancer

in Systems Immunology

Jingsong Cheng
Nanting Chen
Qingyao Yin
Ziheng Zheng
Xue Chen
Xinyi Zhu
Yuanyuan Wan
Ningxi Wang
Siqi Luo
Chengxi Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678096

255 views

Original Research

Accepted on 30 Sep 2025

Identification of Genes Associated with Disulfidptosis in the Subacute Phase of Spinal Cord Injury and Analysis of Potential Therapeutic Targets

in Systems Immunology

Shenglong Wang
Xiaochen Su
Wenting Xu
Yonghui Zhao
Yulong Zhang
Yingang Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642757

197 views