Frontiers in Immunology | Parasite Immunology

Original Research

Published on 05 Dec 2025

Proteomics-driven screening of artemisinin-based combination ratios and mechanistic insights into Plasmodium berghei infection in mice

in Parasite Immunology

Liyu Hao
Jianhui Sun
Jianliang Li
Zongyuan Li
Zeyue Yu
Hanhui Huang
Guimin Liu
Zhenru Shen
Hairu Huo
Qili Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716096

1,362 views

Original Research

Published on 27 Nov 2025

Functional and phenotypic analysis of CD4 T cell dynamics in peripheral blood of human visceral leishmaniasis patients confers increased frequencies of CD25 expressing regulatory T cells that contribute to disease pathogenesis

in Parasite Immunology

Mohd Kamran
Smriti Ghosh
Pradyot Bhattacharya
Sneha Ghosh Chaudhury
Anirban Bhattacharyya
George Banik
Mohammad Asad
Sarfaraz Ahmad Ejazi
Major Madhukar
Krishna Pandey

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676937

1,416 views

Original Research

Published on 20 Nov 2025

Mitochondrial damage and IL-1β production in monocytes caused by Neospora caninum infection are mediated by dense granule protein 7 and prohibitins

in Parasite Immunology

Yu Chen
Naomi Shimoda
Coh-ichi Nihei
Ryuichi Sawa
Yuko Takahashi
Mitsuhiro Nishigori
Shu Nakamura
Jingwei Liu
Takumi Koshiba
Nanako Ushio-Watanabe

Frontiers in Immunology

doi 10.3389/fimmu.2025.1408992

1,665 views

Editorial

Published on 17 Nov 2025

Editorial: Helminthosis: immuno-pathology and anthelmintic vaccines

in Parasite Immunology

Joydeep Paul
Muhammad Tofazzal Hossain
Md. Aminul Islam
Anisuzzaman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727852

1,154 views

Original Research

Published on 10 Nov 2025

Identification of Plasmodium falciparum VAR2CSA peptides differentially recognized by IgG of multigravidae through epitope excision

in Parasite Immunology

Santosh A. Misal
Jonathan P. Renn
Robert D. Morrison
Matthew V. Cowles
Almahamoudou Mahamar
Oumar Attaher
Alassane Dicko
Patrick E. Duffy
Michal Fried

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704346

1,316 views

Review

Published on 05 Nov 2025

Clinical challenges and technological breakthroughs in helminthic therapy for diabetes

in Parasite Immunology

Yunhuan Zhu
Xinyi Fei
Ruke Wang
Jiyuan Wang
Xianwei Li
Yijie Zhang
Jialu Xu
Qingzhi Zhao
Keda Chen
Xiaofen Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642707

2,670 views
1 citation

Review

Published on 30 Oct 2025

Breaking the bind: PfEMP1-specific antibodies in cerebral malaria

in Parasite Immunology

Josephine P. Banda
Isobel S. Walker
Tonney Nyirenda
Elizabeth H. Aitken
Stephen J. Rogerson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681852

2,138 views

Original Research

Published on 30 Oct 2025

Early responses of primary human and bovine monocytes, monocytic THP-1 cells and THP-1 cell-derived macrophages to vital Toxoplasma gondii tachyzoites

in Parasite Immunology

Dominik Hanke
Zahady D. Velásquez
Kathrin Büttner
Andreas Krueger
Ralf Ross
Andreas Hecker
Sybille Mazurek
Veronika Grau
Anja Taubert
Carlos Hermosilla

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683634

9,788 views

Original Research

Published on 24 Oct 2025

New mechanistic insights into macrophage extracellular trap formation induced by a parasitic nematode, Strongyloides stercoralis

in Parasite Immunology

Taoxun Zhou
Bingying Zhang
Runxin Zhu
Chunqun Wang
Hui Liu
Nishith Gupta
Min Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636232

2,957 views

Original Research

Published on 24 Oct 2025

Micro-geographic variation in antigenic diversity of PfEBA-175 region II in asymptomatic Plasmodium falciparum infections in Tanzania

in Parasite Immunology

Jadidan Hada Syahada
Wang-Jong Lee
Hojong Jun
Johnsy Mary Louis
Fadhila Fitriana
Fauzi Muh
Feng Lu
Md Atique Ahmed
Sunghun Na
Wanjoo Chun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656267

2,141 views

Review

Published on 15 Oct 2025

Comparative immunological roles of TEP1 in Anopheles gambiae and Biomphalaria glabrata: implications for malaria and schistosomiasis control

in Parasite Immunology

Hongyu Li
Yilu Feng
Yuncheng Qian
Wenjie Jiang
Yunhuan Zhu
Jialu Xu
Xianwei Li
Xinyi Fei
Ruke Wang
Yuqing Shao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629262

2,019 views
1 citation

Original Research

Published on 14 Oct 2025

Non-additive strong gene interactions cause striking differences in organ pathology and cytokine response in Leishmaniasis

in Parasite Immunology

Yahya Sohrabi
Tatyana Kobets
Valeriya Volkova
Eliška Javorková
Imtissal Krayem
Alena Zajícová
Helena Havelková
Milena Svobodová
Vladimír Holáň
Peter Demant

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579257

2,227 views

Original Research

Published on 02 Oct 2025

The effect of treatment with a non-ionic surfactant vesicular formulation of sodium stibogluconate on host immune responses and serum metabolites in a murine model of Leishmania donovani

in Parasite Immunology

Raphael Taiwo Aruleba
Bernard Ong’ondo Osero
Du Toit Loots
Laneke Luies
Zama Cele
Priscilla Abena Ankamaa Opare
Mari van Reenen
Frank Brombacher
Katharine C. Carter
Ramona Hurdayal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1499513

2,651 views

Original Research

Published on 01 Oct 2025

Humoral immune response to COVID-19 vaccines in onchocerciasis-infected individuals: a field study from Ghana

in Parasite Immunology

Julia Meyer
Ute Klarmann-Schulz
Jennifer Nadal
Marijo Parcina
Linda Batsa Debrah
Jubin Osei-Mensah
Derrick Adu Mensah
Monica Ahiadorme
Vera Serwaa Opoku
Michael Agyemang Obeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633187

5,328 views

Original Research

Published on 25 Sep 2025

Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction

in Parasite Immunology

Leonardo Elias Sternkopf
Ulrich Fabien Prodjinotho
Vitka Gres
Nikolaus Repgen
Katja Steiger
Julia Schluckebier
Chummy S. Sikasunge
Dominik Stelzle
Charles Makasi
Andrea Sylvia Winkler

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603385

3,722 views

Correction

Published on 15 Sep 2025

Correction: Characteristics and immunoprotective functions of three cysteine proteases from Clonorchis sinensis

in Parasite Immunology

Yunliang Shi
Xiaoqin Li
Kai Liang
Ting Lu
Yu Chen
Yashi Lai
Yaoting Li
Shuai Wei
Shanshan He
Lili Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663826

2,790 views

Original Research

Published on 15 Sep 2025

Controlled human malaria infection with NF54 and 7G8 strains elicit differential antibody responses to Plasmodium falciparum peptides

in Parasite Immunology

DeAnna J. Friedman-Klabanoff
Travis L. Jensen
Kirsten E. Lyke
Matthew B. Laurens
Joana C. Silva
Emily M. Stucke
Amed Ouattara
Olukemi O. Ifeonu
Theresa Hodges
Kara A. Moser

Frontiers in Immunology

doi 10.3389/fimmu.2025.1641280

4,050 views

Original Research

Published on 12 Sep 2025

Proteomics of plasma-derived extracellular vesicles from human patients identifies biomarkers for monitoring visceral leishmaniasis therapy

in Parasite Immunology

Ana Torres
Ana Montero-Calle
Marina Lozano-Rendal
Carmen Sánchez
Lorena Bernardo
Jose Carlos Solana
Juan Victor San Martin
Rodrigo Barderas
Javier Moreno
Eugenia Carrillo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646335

5,294 views
1 citation

Correction

Published on 12 Sep 2025

Correction: Tick cysteine protease inhibitors suppress immune responses in mannan-induced psoriasis-like inflammation

in Parasite Immunology

Huimei Wu
Mohamed Amine Jmel
Jinwei Chai
Maolin Tian
Xueqing Xu
Yuan Hui
Kutty Selva Nandakumar
Michail Kotsyfakis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699570

1,528 views

Original Research

Published on 11 Sep 2025

Seroprevalence of antibodies to Plasmodium falciparum transmission-blocking target proteins Pfs230D1M and Pfs48/45 in Tanzanian populations of diverse malaria transmission intensity

in Parasite Immunology

Charles Mulamba
Wilmina F. Kalinga
Ivanny Mtaka
Linda O. Lazaro
Janeth Kamage
Irene Nkumama
Olukayode G. Odufuwa
Katharina Kreppel
David Mekhaiel
Kazutoyo Miura

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589061

3,238 views
1 citation

Editorial

Published on 11 Sep 2025

Editorial: Skin - confluence of vertebrate host defences, arthropod vectors, and vector-borne pathogens

in Parasite Immunology

Sukanya Narasimhan
Maria Kazimirova
Stephen Wikel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688830

3,396 views

Original Research

Published on 04 Sep 2025

Integrated transcriptomic and proteomic analysis of the immune response in Hyalomma anatolicum to bacterial invasion

in Parasite Immunology

Jianlong Li
Tingxiang Luo
Zhen Ma
Depeng Yang
Sen Yang
Yongchang Li
Bayinchahan Gailike
Qingyong Guo
Zhengxiang Hu
Ercha Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1576721

2,467 views

Original Research

Published on 04 Sep 2025

miR-378a-5p targeting BRAF regulates CD4+T cells differentiation to Th1 under rEg.P29 induction

in Parasite Immunology

Tingting Zhang
Hu Mu
Chuan Wang
Bingshuo Qian
Mingxing Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620225

2,104 views

Original Research

Published on 27 Aug 2025

Role of the CX3CL1/CX3CR1 axis in iron metabolism and immune regulation during acute Trypanosoma cruzi infection

in Parasite Immunology

Sirlaine Pio
Tatiana Prata Menezes
Vitória Louise
Guilherme de Paula Costa
Daniel Malta Oliveira
Natiele Carlos
Silvia Paula-Gomes
Luiza Oliveira Perucci
André Talvani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1585883

3,521 views

455 articles

articles

Proteomics-driven screening of artemisinin-based combination ratios and mechanistic insights into Plasmodium berghei infection in mice

Functional and phenotypic analysis of CD4 T cell dynamics in peripheral blood of human visceral leishmaniasis patients confers increased frequencies of CD25 expressing regulatory T cells that contribute to disease pathogenesis

Mitochondrial damage and IL-1β production in monocytes caused by Neospora caninum infection are mediated by dense granule protein 7 and prohibitins

Editorial: Helminthosis: immuno-pathology and anthelmintic vaccines

Identification of Plasmodium falciparum VAR2CSA peptides differentially recognized by IgG of multigravidae through epitope excision

Clinical challenges and technological breakthroughs in helminthic therapy for diabetes

Breaking the bind: PfEMP1-specific antibodies in cerebral malaria

Early responses of primary human and bovine monocytes, monocytic THP-1 cells and THP-1 cell-derived macrophages to vital Toxoplasma gondii tachyzoites

New mechanistic insights into macrophage extracellular trap formation induced by a parasitic nematode, Strongyloides stercoralis

Micro-geographic variation in antigenic diversity of PfEBA-175 region II in asymptomatic Plasmodium falciparum infections in Tanzania

Comparative immunological roles of TEP1 in Anopheles gambiae and Biomphalaria glabrata: implications for malaria and schistosomiasis control

Non-additive strong gene interactions cause striking differences in organ pathology and cytokine response in Leishmaniasis

The effect of treatment with a non-ionic surfactant vesicular formulation of sodium stibogluconate on host immune responses and serum metabolites in a murine model of Leishmania donovani

Humoral immune response to COVID-19 vaccines in onchocerciasis-infected individuals: a field study from Ghana

Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction

Correction: Characteristics and immunoprotective functions of three cysteine proteases from Clonorchis sinensis

Controlled human malaria infection with NF54 and 7G8 strains elicit differential antibody responses to Plasmodium falciparum peptides

Proteomics of plasma-derived extracellular vesicles from human patients identifies biomarkers for monitoring visceral leishmaniasis therapy

Correction: Tick cysteine protease inhibitors suppress immune responses in mannan-induced psoriasis-like inflammation

Seroprevalence of antibodies to Plasmodium falciparum transmission-blocking target proteins Pfs230D1M and Pfs48/45 in Tanzanian populations of diverse malaria transmission intensity

Editorial: Skin - confluence of vertebrate host defences, arthropod vectors, and vector-borne pathogens

Integrated transcriptomic and proteomic analysis of the immune response in Hyalomma anatolicum to bacterial invasion

miR-378a-5p targeting BRAF regulates CD4+T cells differentiation to Th1 under rEg.P29 induction

Role of the CX3CL1/CX3CR1 axis in iron metabolism and immune regulation during acute Trypanosoma cruzi infection