Frontiers in Immunology | Multiple Sclerosis and Neuroimmunology

Original Research

Published on 28 Oct 2025

Intestinal mucosal alterations parallel central demyelination and remyelination: insights into the gut-brain axis in the cuprizone model of multiple sclerosis

in Multiple Sclerosis and Neuroimmunology

Carolina Ferreira
Filipa Carvalho
Pedro Vieira
André Alves
Filipe Palavra
Jani Almeida
Vera Alves
Ezequiel Coscueta
Patrícia Dias Pereira
Manuela Pintado

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682183

3,104 views

Brief Research Report

Published on 27 Oct 2025

Combination therapy of ofatumumab and daratumumab in patients with severe anti-NMDA receptor encephalitis

in Multiple Sclerosis and Neuroimmunology

Baojie Wang
Yufeng Chu
Chao Zhang
Shougang Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681884

1,764 views

Original Research

Published on 27 Oct 2025

The ATP-mediated cytokine release by macrophages is down-modulated by unconventional α9* nicotinic acetylcholine receptors

in Multiple Sclerosis and Neuroimmunology

Philipp M. K. Wolf
Dominik Hanke
Vijay K. Singh
Hanno L. Keller
Luca J. Ettischer
Laura Teppe
Anca-Laura Amati
Andreas Hecker
Faeq Husain-Syed
Marius Rohde

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661114

2,383 views

Original Research

Published on 27 Oct 2025

The diagnostic and prognostic value of CXCL13, CXCL10, and CXCL8 in patients with neurosyphilis

in Multiple Sclerosis and Neuroimmunology

Hongjing Guan
Jingli Peng
Zihao Xia
Xiaoyun Di
Qin Wang
Chunmiao Zou
Rentian Cai
Chen Chen
Hongxia Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654251

1,700 views

Original Research

Published on 22 Oct 2025

Global, regional, and national trends and burden of multiple sclerosis in adolescents and young adults: a data analysis from 1990 to 2021 and projections to 2040

in Multiple Sclerosis and Neuroimmunology

Peixi Zhao
Chang Guan
Jing Lu
Ying Zhang
Baitong Wang
Lin Huang
Ding Ye
Hongmei Nan
Jian Wang
Peng Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685316

2,465 views
1 citation

Study Protocol

Published on 22 Oct 2025

The efficacy, safety, and pharmacokinetics/pharmacodynamics of telitacicept following efgartigimod in generalized myasthenia gravis: protocol of a randomized controlled trial

in Multiple Sclerosis and Neuroimmunology

Jia Li
Yuan Zhang
Yan Deng
Wenyu Li
Yiqi Wang
Feiteng Qi
Qiaoyi Zhang
Bingbing Wan
Xiang Li
Yiyun Weng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604786

3,214 views

Original Research

Published on 20 Oct 2025

Polysialic acid restrains inflammatory monocyte maturation

in Multiple Sclerosis and Neuroimmunology

Ingredy Passos
Benjamin Peschke
Shrey Gandhi
Judith Derdelinckx
Louisa Müller-Miny
Harald Neumann
Jan D. Lünemann
Christian W. Keller

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656087

2,345 views
2 citations

Original Research

Published on 20 Oct 2025

Neutrophils from Alzheimer’s disease mice fail to phagocytose debris and show altered release of immune modulators with age

in Multiple Sclerosis and Neuroimmunology

Matthew Kays
Anna Kelly
Farrah McGinnis
Clara Woods
Emily Herron
Candice Brown
Aminata P. Coulibaly

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672768

2,922 views

Original Research

Published on 20 Oct 2025

Immune checkpoint-based biomarkers for therapeutic response in patients with multiple sclerosis

in Multiple Sclerosis and Neuroimmunology

MariPaz López-Molina
Gabriel Torres Iglesias
Gonzalo Sáenz de Santa María-Diez
Jaime Valentín-Quiroga
Fernando Laso-García
Rebeca Gallego
Javier Pozo-Novoa
Beatriz Chamorro
Eduardo López-Collazo
Inmaculada Puertas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694021

2,332 views
1 citation

Review

Published on 15 Oct 2025

The link between gut microbiota and multiple sclerosis from the perspective of barrier function

in Multiple Sclerosis and Neuroimmunology

Jingru Ren
Zhenyu Niu
Jianchun Wang
Jing Guo
Hongjun Hao
Feng Gao
Ran Liu
Zhaoxia Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652796

5,067 views
1 citation

Original Research

Published on 13 Oct 2025

Colonization by Akkermansia muciniphila modulates central nervous system autoimmunity in an ecological context-dependent manner

in Multiple Sclerosis and Neuroimmunology

Daniel Peipert
Theresa L. Montgomery
Lucinda C. Toppen
Margaret Frances J. Lee
Matthew J. Scarborough
Dimitry N. Krementsov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655428

3,116 views

Systematic Review

Published on 08 Oct 2025

Research on Parkinson’s disease immunotherapy: a bibliometric analysis via multiple databases

in Multiple Sclerosis and Neuroimmunology

Xinxing Fei
Shiqi Wang
Jiayi Song
Caihong Cao
Yaqian Gao
Yue Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659848

4,391 views

Perspective

Published on 07 Oct 2025

Targeting senescent microglia in progressive multiple sclerosis: a geroscience-informed approach

in Multiple Sclerosis and Neuroimmunology

Jeffrey Atkinson
Amy Dokiburra
Hayley Groover
Jonathan P. Godbout
Benjamin M. Segal
Yinan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681724

4,226 views

Review

Published on 07 Oct 2025

Glycolytic reprogramming during microglial polarization in neurological diseases

in Multiple Sclerosis and Neuroimmunology

Xiaoting Li
Congcong Fang
Yina Li
Xiaoxing Xiong
Xu Xu
Lijuan Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648887

5,097 views
1 citation

Review

Published on 06 Oct 2025

Neuroinflammation: targeting microglia for neuroprotection and repair after spinal cord injury

in Multiple Sclerosis and Neuroimmunology

Roberta Ramos Cavalcanti
Fernanda Martins Almeida
Ana Maria Blanco Martinez
Camila Marques Freria

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670650

6,541 views
3 citations

Systematic Review

Published on 02 Oct 2025

Exploratory analysis of predictive models in the field of myelitis: a systematic review and meta-analysis

in Multiple Sclerosis and Neuroimmunology

Jingjie Huang
Yusheng Zhao
Ziyi Zhang
Yupei Cheng
Bangqi Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1669338

2,241 views

Original Research

Published on 02 Oct 2025

Aging-dependent immunological changes in multiple sclerosis

in Multiple Sclerosis and Neuroimmunology

Andrea Iribarren-López
Laura Martins-Almeida
Jadon K Wells
Tamara Castillo-Triviño
Álvaro Prada
Hilda A Pickett
Ainhoa Alberro
David Otaegui

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663526

3,041 views
1 citation

Editorial

Published on 30 Sep 2025

Editorial: Remedying the injured brain in cognitive impairment: potential neuroimmune communication signaling and therapeutic opportunities

in Multiple Sclerosis and Neuroimmunology

Zhengsen Jin
Zhongdi Cai
Asma Perveen
George E. Barreto
Linlin Yin
Rong Wang
Rui Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705628

2,084 views

Mini Review

Published on 25 Sep 2025

Rediscovering parainfectious encephalopathy in the post-COVID-19 era

in Multiple Sclerosis and Neuroimmunology

Lin Bai
Chang Geng
Hongzhi Guan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634383

3,184 views

Original Research

Published on 23 Sep 2025

Morphometric MRI findings in patients with suspected autoimmune psychosis spectrum syndromes and association with EEG slowing, CSF changes, and psychometric/neuropsychological findings

in Multiple Sclerosis and Neuroimmunology

Katharina von Zedtwitz
Ludger Tebartz van Elst
Bernd Feige
Isabelle Matteit
Andrea Schlump
Thomas Lange
Kimon Runge
Kathrin Nickel
Nils Venhoff
Katharina Domschke

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648946

2,605 views
3 citations

Original Research

Published on 19 Sep 2025

Exploratory study on autoantibodies to arginine-rich human peptides mimicking Epstein-Barr virus in women with post-COVID and myalgic encephalomyelitis/chronic fatigue syndrome

in Multiple Sclerosis and Neuroimmunology

Friederike Hoheisel
Kathrin Maria Fleischer
Kerstin Rubarth
Nuno Sepúlveda
Sandra Bauer
Frank Konietschke
Claudia Kedor Peters
Annika Elisa Stein
Kirsten Wittke
Martina Seifert

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650948

9,716 views
2 citations

Editorial

Published on 18 Sep 2025

Editorial: Novel CNS targeting molecules, methods, and therapeutics in multiple sclerosis

in Multiple Sclerosis and Neuroimmunology

Rune Alexander Aamodt Høglund
Stella E. Tsirka
Makoto Inoue

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699850

3,203 views

Original Research

Published on 18 Sep 2025

Human pluripotent stem cell–derived neuronal progenitor cells promote neurogenesis and functional recovery by attenuating neuroinflammation and via extracellular vesicles in a subacute stroke model

in Multiple Sclerosis and Neuroimmunology

Hyun-Jin Kim
Dong Hee Kim
Jee In Choi
Hye Ryeong Sim
Sangyong Jung
Dong-Youn Hwang
MinYoung Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650092

3,431 views

Editorial

Published on 15 Sep 2025

Editorial: Bone marrow aging and its impact on immunosenescence in neurological diseases

in Multiple Sclerosis and Neuroimmunology

Junchi He
William G. Kerr
Xingzhi Guo
Dan Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697136

3,413 views

1,513 articles

articles

Intestinal mucosal alterations parallel central demyelination and remyelination: insights into the gut-brain axis in the cuprizone model of multiple sclerosis

Combination therapy of ofatumumab and daratumumab in patients with severe anti-NMDA receptor encephalitis

The ATP-mediated cytokine release by macrophages is down-modulated by unconventional α9* nicotinic acetylcholine receptors

The diagnostic and prognostic value of CXCL13, CXCL10, and CXCL8 in patients with neurosyphilis

Global, regional, and national trends and burden of multiple sclerosis in adolescents and young adults: a data analysis from 1990 to 2021 and projections to 2040

The efficacy, safety, and pharmacokinetics/pharmacodynamics of telitacicept following efgartigimod in generalized myasthenia gravis: protocol of a randomized controlled trial

Polysialic acid restrains inflammatory monocyte maturation

Neutrophils from Alzheimer’s disease mice fail to phagocytose debris and show altered release of immune modulators with age

Immune checkpoint-based biomarkers for therapeutic response in patients with multiple sclerosis

The link between gut microbiota and multiple sclerosis from the perspective of barrier function

Colonization by Akkermansia muciniphila modulates central nervous system autoimmunity in an ecological context-dependent manner

Research on Parkinson’s disease immunotherapy: a bibliometric analysis via multiple databases

Targeting senescent microglia in progressive multiple sclerosis: a geroscience-informed approach

Glycolytic reprogramming during microglial polarization in neurological diseases

Neuroinflammation: targeting microglia for neuroprotection and repair after spinal cord injury

Exploratory analysis of predictive models in the field of myelitis: a systematic review and meta-analysis

Aging-dependent immunological changes in multiple sclerosis

Editorial: Remedying the injured brain in cognitive impairment: potential neuroimmune communication signaling and therapeutic opportunities

Rediscovering parainfectious encephalopathy in the post-COVID-19 era

Morphometric MRI findings in patients with suspected autoimmune psychosis spectrum syndromes and association with EEG slowing, CSF changes, and psychometric/neuropsychological findings

Exploratory study on autoantibodies to arginine-rich human peptides mimicking Epstein-Barr virus in women with post-COVID and myalgic encephalomyelitis/chronic fatigue syndrome

Editorial: Novel CNS targeting molecules, methods, and therapeutics in multiple sclerosis

Human pluripotent stem cell–derived neuronal progenitor cells promote neurogenesis and functional recovery by attenuating neuroinflammation and via extracellular vesicles in a subacute stroke model

Editorial: Bone marrow aging and its impact on immunosenescence in neurological diseases