Frontiers in Immunology | Immunological Tolerance and Regulation

Original Research

Published on 16 Oct 2025

Ex vivo expanded human regulatory T cells promote cholesterol efflux and PON1 expression in oxLDL-exposed macrophages via gap junction-mediated cAMP transfer

in Immunological Tolerance and Regulation

Caraugh Jane Albany
Daniela Mastronicola
Momchil Popov
Wladislaw Stroukov
Anthony S. Wierzbicki
Rocio Teresa Martinez-Nunez
Giovanna Lombardi
Cristiano Scottà

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662925

1,406 views

Original Research

Accepted on 15 Oct 2025

Immune Tolerance Induction Using the Thyrotropin Receptor Epitope 78–94 (p37) Prevents Graves' Disease in HLA-DR3 Transgenic Mice

in Immunological Tolerance and Regulation

Hidefumi Inaba
Itsuki Nonaka
Daiki Hashimoto
Moritoshi Hirono
Shuhei Morita
Hiroaki Kimura
Hiroshi Iwakura
Takashi Akamizu
Masanori Nakata

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633350

Mini Review

Published on 15 Oct 2025

Communication between gut microbiota-derived metabolites and the tumor microenvironment

in Immunological Tolerance and Regulation

Xinyi Hu
Bo Li
Yuanqing Li
Yushan Liang
Tingting Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649438

280 views

Review

Published on 15 Oct 2025

Immune responses in retinal gene therapy: challenges, mechanisms, and future strategies

in Immunological Tolerance and Regulation

Yawei Ma
Yin Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664968

315 views

Review

Accepted on 14 Oct 2025

Use of regulatory cells (RC) for achieving functional tolerance to pig heart xenotransplants in humans: a literature review

in Immunological Tolerance and Regulation

Gheorghe Braileanu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648926

197 views

Original Research

Accepted on 14 Oct 2025

Proteomic analysis of Exosomes from Brucella abortus-infected Macrophages Reveals Possible Mechanisms of Immune Evasion and Host Modulation

in Immunological Tolerance and Regulation

Francisco Alvarez
Vicente Arriagada
Maria Jasús Aburto
Ítalo Ferrari H.
Ilse Alvarado Muñoz
José Barrales
ROBERTO Mauricio VIDAL
Felipe Del Canto
Leonardo A. Gómez
Angel Alejandro Oñate

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685245

137 views

Systematic Review

Accepted on 09 Oct 2025

Comparing the circulating immune profile of women with and without recurrent implantation failure: a systematic review and meta-analysis

in Immunological Tolerance and Regulation

Daxina Bhatt
Yousef Alebrahim
Abdullah Shahzad
Lamiya Mohiyiddeen
Elizabeth Mann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627514

Clinical Trial

Accepted on 09 Oct 2025

Immunomodulatory Effects and Mechanisms of Qi-Xu-Tiao-Ti Formula in Qi-Deficiency Constitution: A Randomized Controlled Trial Integrated with Multi-Omics and Network Pharmacology Analysis

in Immunological Tolerance and Regulation

Renyun Cui
Ming Fan
Chengzhi Yang
Cheng Chen
Jinlu Xia
Xi Liu
Guohui Zhang
Fangli Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675502

141 views

Original Research

Published on 08 Oct 2025

Bioinformatics identification of mitochondria and macrophage polarization-related genes in COPD and their potential mechanisms

in Immunological Tolerance and Regulation

Chenchen Zhang
Peishu Fu
Juanchun Yu
Lingling Liu
Xiong Wei
Xiao Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675292

1,682 views

Original Research

Accepted on 03 Oct 2025

Human leukocyte antigen-G isoform HLA-G2/6, but not HLA-G1/4/5, is an independent indicator of poor survival in patients with colorectal cancer

in Immunological Tolerance and Regulation

Xia Zhang
Qiu-Yue Han
Jian-Gang Zhang
Jiao Lin
Wei-Hua Yan
Aifen Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672144

179 views

Original Research

Accepted on 02 Oct 2025

Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages

in Immunological Tolerance and Regulation

Ying-qing Gan
Yuan-wen Cai
Xiu-wen Liang
Fu-li Shi
Nuo Sun
Ya-Ping Li
Rong Xu
Bo Hu
Qing-bing Zha
Xian-Hui He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631152

323 views

Original Research

Published on 30 Sep 2025

Single-cell mRNA analysis and surface marker expression profiling of circulating immune cells in humans with alpha-gal syndrome

in Immunological Tolerance and Regulation

Shailesh K. Choudhary
Scott P. Commins

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629310

1,109 views

Original Research

Published on 25 Sep 2025

Gut commensal bacteria-derived polysaccharide sub-micron particles induce antigen-specific, tolerogenic responses

in Immunological Tolerance and Regulation

Rian Harriman
Allen B. Tu
Zhenyu Wang
Nicolas Radoc
Hamilton Kakwere
Jamal S. Lewis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599480

2,240 views

Correction

Published on 23 Sep 2025

Correction: Recurrent reproductive failure and celiac genetic susceptibility, a leading role of gluten

in Immunological Tolerance and Regulation

Eduardo de la Fuente-Munoz
Miguel Fernández-Arquero
Nabil Subhi-Issa
Kissy Guevara-Hoyer
Lydia Pilar Suárez
Raquel Gil Laborda
Marina Sánchez
Juliana Ochoa-Grullón
María Guzmán-Fulgencio
Ángela Villegas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701918

2,682 views

Original Research

Published on 22 Sep 2025

Multi-omic analysis identifies erythroid cells as the major population in mouse placentas expressing genes for antigen presentation in MHC class II, chemokines, and antibacterial immune response

in Immunological Tolerance and Regulation

Olga Perik-Zavodskaia
Roman Perik-Zavodskii
Saleh Alrhmoun
Kirill Nazarov
Julia Shevchenko
Konstantin Zaitsev
Sergey Sennikov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1644983

2,155 views

Review

Published on 19 Sep 2025

Gaps in maternal-fetal interface rejection response: chronic histiocytic intervillositis

in Immunological Tolerance and Regulation

Xiaoqian Zhang
Zhenya Fang
Xietong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1625701

3,016 views