Frontiers in Immunology | Cytokines and Soluble Mediators in Immunity

Clinical Trial

Published on 09 Dec 2024

Evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of SM17 in healthy volunteers: results from pre-clinical models and a first-in-human, randomized, double blinded clinical trial

in Cytokines and Soluble Mediators in Immunity

Guolin Xu
Sabina Paglialunga
Xuchen Qian
Ru Ding
Kenneth Webster
Aernout van Haarst
Caroline Engel
Chin Wai Hui
Lik Hang Lam
Weimin Li

Frontiers in Immunology

doi 10.3389/fimmu.2024.1495540

2,034 views
2 citations

Original Research

Published on 06 Dec 2024

Time-dependent variation in immunoparalysis biomarkers among patients with sepsis and critical illness

in Cytokines and Soluble Mediators in Immunity

Abigail Samuelsen
Erik Lehman
Parker Burrows
Anthony S. Bonavia

Frontiers in Immunology

doi 10.3389/fimmu.2024.1498974

816 views

Original Research

Published on 04 Dec 2024

Cytokine profiling reveals HLA-linked Th2 and Th17 driven immune activation in pemphigus vulgaris patients and genetically susceptible healthy controls

in Cytokines and Soluble Mediators in Immunity

Rebekah R. Schwartz
Kristina Seiffert-Sinha
Animesh A. Sinha

Frontiers in Immunology

doi 10.3389/fimmu.2024.1500231

960 views
1 citation

Original Research

Published on 27 Nov 2024

Extracellular vesicles epitopes as potential biomarker candidates in patients with traumatic spinal cord injury

in Cytokines and Soluble Mediators in Immunity

Jason-Alexander Hörauf
Cora Rebecca Schindler
Inna Schaible
Minhong Wang
Birte Weber
André El Saman
Christiane Pallas
Marek Widera
Ingo Marzi
Dirk Henrich

Frontiers in Immunology

doi 10.3389/fimmu.2024.1478786

912 views

Original Research

Published on 21 Nov 2024

Modulation of the hepatic RANK-RANKL-OPG axis by combined C5 and CD14 inhibition in a long-term polytrauma model

in Cytokines and Soluble Mediators in Immunity

Yang Li
Klemens Horst
Johannes Greven
Ümit Mert
Ludmila Lupu
Annette Palmer
Lena Doerfer
Qun Zhao
Xing Zhang
Rebecca Halbgebauer

Frontiers in Immunology

doi 10.3389/fimmu.2024.1434274

1,220 views

Original Research

Published on 13 Nov 2024

Autoantibodies targeting interferons and GM-CSF are associated with adverse outcome risk, comorbidities, and pathogen in community-acquired pneumonia

in Cytokines and Soluble Mediators in Immunity

Jakob Hjorth Von Stemann
Arnold Matovu Dungu
Maria Vispe Laguarda
Camilla Koch Ryrsø
Maria Hein Hegelund
Daniel Faurholt-Jepsen
Rikke Krogh-Madsen
Morten Bagge Hansen
Birgitte Lindegaard
Sisse Rye Ostrowski

Frontiers in Immunology

doi 10.3389/fimmu.2024.1459616

1,517 views

Original Research

Published on 07 Nov 2024

Effects of COVID-19 on bone fragility: a new perspective from osteoimmunological biomarkers

in Cytokines and Soluble Mediators in Immunity

Emanuela Galliera
Luca Massaccesi
Laura Mangiavini
Elena De Vecchi
Francesca Villa
Massimiliano Marco Corsi Romanelli
Giuseppe Peretti

Frontiers in Immunology

doi 10.3389/fimmu.2024.1493643

1,126 views
1 citation

Original Research

Published on 04 Nov 2024

Leveraging long-acting IL-15 agonists for intratumoral delivery and enhanced antimetastatic activity

in Cytokines and Soluble Mediators in Immunity

John A. Hangasky
Rocío del Valle Fernández
Dimitris Stellas
Guillermo Hails
Sevasti Karaliota
Gary W. Ashley
Barbara K. Felber
George N. Pavlakis
Daniel V. Santi

Frontiers in Immunology

doi 10.3389/fimmu.2024.1458145

1,558 views

Original Research

Published on 29 Oct 2024

An early HMGB1 rise 12 hours before creatinine predicts acute kidney injury and multiple organ failure in a smoke inhalation and burn swine model

in Cytokines and Soluble Mediators in Immunity

Zhangsheng Yang
Tomas S. Cancio
Robert P. Willis
Matthew D. Young
Dustin M. Kneifel
Jose Salinas
Andrew D. Meyer

Frontiers in Immunology

doi 10.3389/fimmu.2024.1447597

1,561 views

Original Research

Published on 28 Oct 2024

Delayed macrophage targeting by clodronate liposomes worsens the progression of cytokine storm syndrome

in Cytokines and Soluble Mediators in Immunity

Kunjan Khanna
Emily Eul
Hui Yan
Roberta Faccio

Frontiers in Immunology

doi 10.3389/fimmu.2024.1477449

1,625 views

Original Research

Published on 23 Oct 2024

Enhancement of a one-step membrane technique for the treatment of large bone defects by pre-seeding the membrane with CD8 lymphocyte depleted bone marrow mononuclear cells in a rat femoral defect model

in Cytokines and Soluble Mediators in Immunity

Marissa Penna-Martinez
Andreas Kammerer
Pia Stützle
Sabatian Fees
Savina Behr
Inna Schaible
Katrin Schröder
René Danilo Verboket
Jonas Neijhoft
Ingo Marzi

Frontiers in Immunology

doi 10.3389/fimmu.2024.1488611

918 views

Original Research

Published on 21 Oct 2024

Cytokine production in an ex vivo model of SARS-CoV-2 lung infection

in Cytokines and Soluble Mediators in Immunity

Daria A. Vorobyeva
Daria M. Potashnikova
Elena V. Maryukhnich
George I. Rusakovich
Anna V. Tvorogova
Anna I. Kalinskaya
Natalia V. Pinegina
Anna V. Kovyrshina
Inna V. Dolzhikova
Alexander B. Postnikov

Frontiers in Immunology

doi 10.3389/fimmu.2024.1448515

1,143 views

Original Research

Published on 21 Oct 2024

Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis

in Cytokines and Soluble Mediators in Immunity

Zi Yang
Mangnan Liu
Zhichao Chang
Conglin Du
Yang Yang
Chen Zhang
Liang Hu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1465938

2,526 views
1 citation

Original Research

Published on 18 Oct 2024

Circulating IL-17F, but not IL-17A, is elevated in severe COVID-19 and leads to an ERK1/2 and p38 MAPK-dependent increase in ICAM-1 cell surface expression and neutrophil adhesion on endothelial cells

in Cytokines and Soluble Mediators in Immunity

Jérôme Bédard-Matteau
Antoine Soulé
Katelyn Yixiu Liu
Lyvia Fourcade
Douglas D. Fraser
Amin Emad
Simon Rousseau

Frontiers in Immunology

doi 10.3389/fimmu.2024.1452788

1,691 views
2 citations

Original Research

Published on 14 Oct 2024

Surviving septic patients endotyped with a functional assay demonstrate active immune responses

in Cytokines and Soluble Mediators in Immunity

Adam D. Price
Ellen R. Becker
Evan L. Barrios
Monty B. Mazer
Patrick W. McGonagill
Christian B. Bergmann
Michael D. Goodman
Robert W. Gould
Mahil Rao
Valerie E. Polcz

Frontiers in Immunology

doi 10.3389/fimmu.2024.1418613

1,844 views

Original Research

Published on 09 Oct 2024

Role of interleukin-18 in mediating the impacts of celiac disease on osteoporosis: a Mendelian randomization study

in Cytokines and Soluble Mediators in Immunity

Jie Xiang
Xiaoyu Zheng
Lan Luo
Xiaoqiang Yang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1453657

1,923 views