Frontiers in Immunology | Cytokines and Soluble Mediators in Immunity

Original Research

Published on 04 Nov 2025

AIMing for survival: The impact of the free and total AIM concentration in septic patients

in Cytokines and Soluble Mediators in Immunity

Birte Dyck
Ulrich Bosch dos Santos
Corinna Müller
Hartmuth Nowak
Tim Rahmel
Lars Palmowski
Matthias Unterberg
Alexander Wolf
Alexander von Busch
Andrea Witowski

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685119

102 views

Mini Review

Published on 04 Nov 2025

Roles of cytokine storm in sepsis progression: biomarkers, and emerging therapeutic strategies

in Cytokines and Soluble Mediators in Immunity

Weibin You

Frontiers in Immunology

doi 10.3389/fimmu.2025.1696366

212 views

Perspective

Accepted on 03 Nov 2025

Regulatory T Cell Transdifferentiation as a Driver of Obesity and Diabetes

in Cytokines and Soluble Mediators in Immunity

Acelya Yilmazer
Dimitra Maria Zevla
Karsten Kretschmer

Frontiers in Immunology

Systematic Review

Published on 03 Nov 2025

CD137 in tuberculosis: a scoping review of an emerging immune checkpoint at the crossroads of diagnosis, prognosis, and therapy

in Cytokines and Soluble Mediators in Immunity

Nuraddin Nasir Goronyo
Bih H. Chendi
Shalena Naidoo
Novel N. Chegou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682269

801 views

Review

Published on 31 Oct 2025

Mechanistic insights into IL-1β-mediated progression of tendinopathy

in Cytokines and Soluble Mediators in Immunity

Yuchi Zhang
Jiayue Wang
Fanbo Tang
Runzhi Xian
Huanhuan Zhang
Yanlin Yuan
Guoqiang Yang
Guiquan Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657285

494 views

Original Research

Accepted on 28 Oct 2025

SPHK1-Mediated M2 Macrophage Polarization Drives TGF-β1-Dependent Thrombus Fibrosis

in Cytokines and Soluble Mediators in Immunity

Chaosheng Deng
Xiaoyun Chen
Fajiu Li
Guofeng Ma
Haifeng Qiang
Maohe Chen
Shi Chen
Yedong Huang
Xingyue Lai
Qinghuang Lin

Frontiers in Immunology

Review

Accepted on 27 Oct 2025

The Pivotal Role of Cytokines in Liver Disease Pathogenesis and Therapeutic Potential

in Cytokines and Soluble Mediators in Immunity

Li Li
Xuhua Li
Fan Zhang

Frontiers in Immunology

216 views

Mini Review

Accepted on 27 Oct 2025

Cytokine Networks and Therapeutic Advances in Systemic Lupus Erythematosus

in Cytokines and Soluble Mediators in Immunity

Zeping Chen
Shupei Liu
Rui Xie
Pan Zhang
Yue Feng

Frontiers in Immunology

238 views

Mini Review

Published on 24 Oct 2025

The clinical utility of autoantibodies in systemic sclerosis: a review with a focus on cohort differences and standardization

in Cytokines and Soluble Mediators in Immunity

Kazuhiro Komura

Frontiers in Immunology

doi 10.3389/fimmu.2025.1691988

844 views

Original Research

Published on 23 Oct 2025

Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation

in Cytokines and Soluble Mediators in Immunity

Tarek Chekroune
Sandra Carignon
Meriem Taleb
Florence Savigny
Stéphanie Rose
Isabelle Maillet
Catherine Mura

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610033

1,488 views

Original Research

Accepted on 22 Oct 2025

Human Spinal Enthesis Comparative Biology of IL-17F and IL-17A Reveals Greater T-cell IL-17F Induction and IL-23 Regulation

in Cytokines and Soluble Mediators in Immunity

Nicole McDermott
Ala Altaie
Tom Macleod
Charlie Bridgewood
Peter Loughenbury
Robert Dunsmuir
Almas Khan
Vishal Borse
Abhay Rao
Avneet Manghera

Frontiers in Immunology

455 views

Original Research

Accepted on 22 Oct 2025

IL-6 as an integrative biomarker of residual inflammation and visceral adiposity in psoriasis: a VAI threshold-dependent model

in Cytokines and Soluble Mediators in Immunity

Eva Klara Merzel Šabović
Tadeja Kraner Šumenjak
Miodrag Janić

Frontiers in Immunology

454 views

Opinion

Published on 22 Oct 2025

Reframing chronic wound therapy: from growth factor delivery to regenerative immuno-engineering

in Cytokines and Soluble Mediators in Immunity

Zhiyong Wang
Xuan Zeng
Wenzhao Feng
Yanxin Lu
Pei Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683591

637 views

Original Research

Published on 22 Oct 2025

Serum IL-17F as a biomarker of infection-independent cirrhosis progression

in Cytokines and Soluble Mediators in Immunity

Georgios Konstantis
Moritz Passenberg
Clara Guntlisbergen
Andreas Schütte
Björn Jung
Nargiz Nuruzade
Florian Seltsam
Dieter P. Hoyer
Jan Best
Katharina Willuweit

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671288

913 views

Original Research

Accepted on 21 Oct 2025

Interleukin-6 levels and their haplotypes are associated with serological autoantibodies status and clinical activity in rheumatoid arthritis

in Cytokines and Soluble Mediators in Immunity

Ma. Natividad Flores-Castro
Ramcés Falfán-Valencia
Olivia Briceño
Ilse Adriana Gutiérrez-Pérez
Oscar Zaragoza-García
Gloria Pérez-Rubio
Cristina Morales-Martínez
Iris Paola Guzmán-Guzmán

Frontiers in Immunology

411 views

Original Research

Accepted on 21 Oct 2025

Reciprocal activation between M1 macrophages and trophoblasts through CXCL9/STAT1/ZEB1/CCL2 axis promotes recurrent spontaneous abortion

in Cytokines and Soluble Mediators in Immunity

Sisi Yan
Jinli Ding
Hiu Qiu

Frontiers in Immunology

112 views