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REVIEW article
Front. Immunol.
Sec. Molecular Innate Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1563655
This article is part of the Research Topic Unraveling circRNAs and miRNAs: Key Regulators in Immune-Related Diseases View all 4 articles
CircRNAs: A novel potential strategy to treat breast cancer
Provisionally accepted- 1 University of South China, Hengyang, Hunan Province, China
- 2 Sun Yat-sen University Cancer Center (SYSUCC), Guangzhou, China
Breast cancer is among the most prevalent malignant tumors worldwide, with triple-negative breast cancer (TNBC) representing its most aggressive subtype and lacking effective treatment options. Circular RNAs (circRNAs) are non-coding RNAs and play a crucial role in tumor development, including breast cancer. This article focuses the progress on of circRNAs in BC, covering four main areas: 1) breast cancer epidemiology, classification, and treatment; 2) the structure, discovery process, characteristics, formation, and functions of circRNAs; 3) the expression, mechanism, clinical relevance, and the latest advances of circRNAs in breast cancer cells and immune microenvironment, specifically TNBC; and 4) the challenges and future prospects of circRNAs in BC research.
Keywords: breast cancer, Triple-negative breast cancer, CircRNAs, biomarkers, Immune microenvironment Prostate cancer 1,466,680 7.30% Stomach cancer 968,350 4.90% others 10,814,465 54.20%
Received: 20 Jan 2025; Accepted: 20 Feb 2025.
Copyright: © 2025 Chen, Zhang, Wu, Zhang, Wen, Guan and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hailin Tang, Sun Yat-sen University Cancer Center (SYSUCC), Guangzhou, China
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