Skip to main content

REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1542157

Recent Advances in the role of High-salt Diet (HSD) in Anti-and Pro-Cancer Progression

Provisionally accepted
Shiwei Tang Shiwei Tang 1Juan Xu Juan Xu 1Ping Wan Ping Wan 1,2,3Shumen Jin Shumen Jin 4Ying Zhang Ying Zhang 1,2Linting Xun Linting Xun 1,2JinLi Wang JinLi Wang 1,2Mei Luo Mei Luo 1,2Wenjie Chen Wenjie Chen 5Zan Zuo Zan Zuo 1,2,6*Hui Tang Hui Tang 1,2*Jialong Qi Jialong Qi 1,2,3,6,7*
  • 1 The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
  • 2 Yunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People's Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, China
  • 3 Yunnan Province Clinical Research Center for Senile diseases, First People’s Hospital of Yunnan Province, kunming, China
  • 4 Yunnan Institute of Food and Drug Supervision and Control, Medical Products Administration of Yunnan Province, Kunming, China
  • 5 State Key Laboratory of Respiratory Disease, Guangdong-Hongkong-Macao Joint Laboratory of Respiratory Infectious Disease, Guangzhou Medical University,, Guangzhou, China
  • 6 Yunnan Provincial Key Laboratory of Clinical Virology, The First People's Hospital of Yunnan Province, kunming, China
  • 7 Yunnan Provincial Key Laboratory of Birth Defects and Genetic Diseases, First People’s Hospital of Yunnan Province, Kunming, China

The final, formatted version of the article will be published soon.

    Dietary behaviors significantly influence tumor progression, with increasing focus on high-salt diets (HSD) in recent years. Traditionally, HSD has been regarded as a major risk factor for multiple health issues, including hypertension, cardiovascular disease, kidney disease, cancer, and osteoporosis. However, recent studies have uncovered a novel aspect of HSD, suggesting that HSD may inhibit tumor growth in specific pathological conditions by modulating the activity of immune cells that infiltrate tumors and enhancing the effectiveness of PD-1 immunotherapy. This review focused on the duel molecular mechanisms of HSD in cancer development, which are based on the tumor microenvironment, the gut microbiota, and the involvement of sodium transporter channels. The objective of this review is to explore whether HSD could be a potential future oncological therapeutic strategy under specific situation.

    Keywords: high-salt diet (HSD), Immunotherapy, tumour microenvironment (TME), Gut Microbiota, Sodium transporter channels

    Received: 09 Dec 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 Tang, Xu, Wan, Jin, Zhang, Xun, Wang, Luo, Chen, Zuo, Tang and Qi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zan Zuo, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
    Hui Tang, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
    Jialong Qi, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.