Hai Su
1
Yin Peng
1
Xiaoli Zeng
2*The final, formatted version of the article will be published soon.
MINI REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1541467
This article is part of the Research Topic Big Data and Precision Medicine: Diagnosis and Treatment, Drug Discovery, and Integration of Multiple Omics View all 15 articles
Overcoming immune evasion with innovative multi-target approaches for glioblastoma
Provisionally accepted- 1 Department of Neurosurgery of Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China, Chongqing, China
- 2 Department of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China, Jiangxi, China
Glioblastoma (GBM) cells leverage complex endogenous and environmental regulatory mechanisms to drive proliferation, invasion, and metastasis. Tumor immune evasion, facilitated by a multifactorial network, poses a significant challenge to effective therapy, as evidenced by the limited clinical benefits of monotherapies, highlighting the adaptive nature of immune evasion. This review explores glioblastoma's immune evasion mechanisms, the role of ICIs in the tumor microenvironment, and recent clinical advancements, offering theoretical insights and directions for monotherapy and combination therapy in glioblastoma management.
Keywords: Glioblastoma, Immune Evasion, Immunotherapy, PD-1, Immune checkpoint
Received: 07 Dec 2024; Accepted: 02 Jan 2025.
Copyright: © 2025 Su, Peng, Wu and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoli Zeng, Department of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China, Jiangxi, China
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