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MINI REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1535930
This article is part of the Research Topic Mechanistic exploration of personalized immunotherapy for urological cancers and potential strategies for clinical translation View all 3 articles
Tissue-resident memory T cells in urinary tract diseases
Provisionally accepted- 1 The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
- 2 Department of Laboratory Medicine, People’s Hospital of Deyang City, Deyang, China
Tissue-resident memory T (TRM) cells are a specialized subset of memory T cells that permanently reside in non-lymphoid tissues, providing localized and long-lasting immune protection. In the urinary tract, TRM cells play critical roles in defending against infections, mediating tumor immunity, and influencing the pathogenesis of chronic inflammatory diseases. Their therapeutic potential is immense, with promising avenues for vaccine development, enhanced cancer immunotherapy, and targeted treatments for chronic inflammation. However, challenges remain in harnessing their protective roles while minimizing their pathological effects, particularly in immunosuppressive or inflammatory microenvironments. This review explores the diverse roles of TRM cells in urinary tract diseases, including infections, cancer, and chronic inflammation, and discusses therapeutic strategies and future directions for leveraging TRM cells to improve clinical outcomes. By advancing our understanding of TRM cell biology, we can develop innovative interventions that balance their immune-protective and regulatory functions.
Keywords: tissue-resident memory T cells, Urinary Tract, Infection, tumor, Immunotherapy
Received: 28 Nov 2024; Accepted: 11 Feb 2025.
Copyright: © 2025 Xu, Lu and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guanting Lu, Department of Laboratory Medicine, People’s Hospital of Deyang City, Deyang, China
Daoyuan Xie, Department of Laboratory Medicine, People’s Hospital of Deyang City, Deyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.