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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1533007
This article is part of the Research Topic The Role of Ubiquitination in Disease Development, Progression, and Prognosis View all 10 articles
Ubiquitination Regulation of Mitochondrial Homeostasis: A New Sight for the Treatment of Gastrointestinal Tumors
Provisionally accepted- 1 Hangzhou First People's Hospital affiliated to Westlake University Medical School, Hangzhou, China, Hangzhou, China
- 2 School of Clinical Chinese Medicine, Gansu University of Chinese Medicine, Gansu, China
- 3 Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
Mitochondrial homeostasis (MH) refers to the dynamic balance of mitochondrial number, function, and quality within cells. Maintaining MH is significant in the occurrence, development, and clinical treatment of Gastrointestinal (GI) tumors. Ubiquitination, as an important post-translational modification mechanism of proteins, plays a central role in the regulation of MH. Over the past decade, research on the regulation of MH by ubiquitination has focused on mitochondrial biogenesis, mitochondrial dynamics, Mitophagy, and mitochondrial metabolism during these processes. This review summarizes the mechanism and potential therapeutic targets of ubiquitin (Ub)-regulated MH intervention in GI tumors.
Keywords: Mitochondrial homeostasis, Ubiquitination, Gastrointestinal tumors, mitochondrial biogenesis, mitochondrial dynamics, mitophagy, mitochondrial metabolism
Received: 22 Nov 2024; Accepted: 24 Feb 2025.
Copyright: © 2025 Huang, Yang, Liu, Zhang and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Biao Zhang, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
Nengming Lin, Hangzhou First People's Hospital affiliated to Westlake University Medical School, Hangzhou, China, Hangzhou, China
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