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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1525466
This article is part of the Research Topic Molecular Mechanisms and Therapeutic Strategies in Inflammation View all 8 articles
Recent Advances in Adipose-Derived Mesenchymal Stem Cell-Derived Exosomes for Regulating Macrophage Polarization
Provisionally accepted- 1 Renji College, Wenzhou Medical University, Wenzhou, China
- 2 Department of Plastic Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
- 3 Department of Breast Plastic Surgery, Plastic Surgery Hospital (PSH), Chinese Academy of Medical Sciences andPeking Union Medical College, Beijing, China
Adipose-derived mesenchymal stem cells (ADSCs) exhibit superior immunomodulatory properties and have broad therapeutic applications. They induce macrophage M2 polarization for antiinflammatory responses. Exosomes derived from ADSCs (ADSC-EXOs) exhibit biological functions similar to those of ADSCs but can circumvent the limitations associated with cellular injection therapies. Potent anti-inflammatory substances contained in exosomes include the glycoprotein MFGE8, the cytokines such as prostaglandin E2, IL-6, and IGF, as well as non-coding nucleotides (miR-451a, miR-23, miR-30d-5p, let-7, lncRNA DLEU2, circRps5, Circ-Ptpn4, and mmu_ circ_0001359). The anti-inflammatory and immunomodulatory properties of these exosomes provide new perspectives for therapeutic approaches for graft inflammation, bone healing, acute lung injury, kidney stones, myocardial infarction, and diabetes-related diseases. This review summarizes the contents and functions of ADSC-EXOs, outlines their properties and the characteristics of
Keywords: Exosomes, Adipose-derived mesenchymal stem cells, Macrophage polarization, M2 macrophages, Inflammatory diseases
Received: 09 Nov 2024; Accepted: 10 Jan 2025.
Copyright: © 2025 Dong, Fu, Cai, Dai and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yucang He, Department of Plastic Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China
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