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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1515838
Prognostic Analysis and Identification of M7G Immune-Related Genes in Lung Squamous Cell Carcinoma
Provisionally accepted- 1 The Second Affiliated Hospital of Harbin Medical University, Harbin, China
- 2 Department of Respiratory Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
- 3 The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
- 4 Kunming Medical University, Kunming, Yunnan Province, China
Background: In recent years, the clinical application of targeted therapies and immunotherapy has significantly improved survival outcomes for patients with lung adenocarcinomas(LUAD).However, due to fewer mutations, lung squamous cell carcinomas(LUSC) shows limited efficacy with targeted and immunotherapy, resulting in a notably lower 5-year survival rate compared to lung adenocarcinoma. The m7G modification plays an important role in tumorigenesis, progression, immune evasion, and therapeutic response. This study aims to develop a novel scoring system based on m7G modification and immune status to clinically predict the prognosis of patients with LUSC and to provide new therapeutic targets.Methods: In this study, we utilized RNA-seq data from the TCGA-LUSC database as the training set and GSE50081 from the GEO database as the validation set. Immunotherapy data were obtained from the IMMPORT database, and m7G data from previous research. Using bioinformatics, we developed a prognostic model for LUSC based on m7G pathway-related immune gene characteristics. We analyzed the correlation between the prognostic model and clinical pathological features of LUSC, as well as the model's independent prognostic capability. Subsequently, patients were divided into high-risk and low-risk groups, and we examined the differences in enriched pathways, immune cell infiltration correlations, and drug sensitivity between the two groups.Results: The m7G immune-related genes FGA, CSF3R, and ORM1 increase the survival risk in patients with lung squamous cell carcinoma, whereas NTS exerts a protective effect. The prognostic risk model for lung squamous cell carcinoma (LUSC) based on m7G immune-related gene expression demonstrates that the overall survival of the high-risk group is significantly poorer than that of the low-risk group.The risk model developed based on m7G immune-related genes can help predict the clinical prognosis of LUSC patients and guide treatment decisions.
Keywords: m7G, lung squamous cell carcinomas (LUSC), immune-related genes, prognostic, Risk model
Received: 23 Oct 2024; Accepted: 04 Feb 2025.
Copyright: © 2025 Li, Nan, Jiayi, Ye, He, Li, Hongtao and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wenhui Li, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Hui Tian, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China
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