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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1497095
This article is part of the Research Topic Immunological Aspects of Fibrosis Pathogenesis: Novel Mechanisms and Therapeutic Strategies View all 10 articles
The role of the interleukin family in liver fibrosis
Provisionally accepted
Zhang Zixin 1,2
Wang JIahui 2* Li Hui 1* Niu Qun 1,2* Tao Yujing 1,2* Zhao Xin 1,2*
Zeng Zijian 1,2
Dong Haijian 1,2- 1 Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 2 School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Liver fibrosis represents a wound-healing response to chronic liver injury caused by viral infections, alcohol, and chemicals agents. It is a critical step in the progression from chronic liver disease to cirrhosis and hepatocellular carcinoma. No chemical or biological drugs have been approved for the treatment of liver fibrosis. Relevant studies have demonstrated that effective inhibition of hepatitis B virus (HBV) replication by nucleoside (acid) analogs or polyethylene glycol alpha-interferon can lead to recovery in some patients with hepatitis B liver fibrosis, However, some patients with liver fibrosis do not show improvement，even after achieving a complete serologic and virologic response. A similar situation occurs in patients with hepatitis C-related liver fibrosis.The liver, with its unique anatomical and immunological structure, is the largest immune organ and produces a large number of cytokines in response to external stimuli, which are crucial for the progression of liver fibrosis. cytokines can act either by directly affecting hepatic stellate cells (HSCs) or by indirectly regulating immune target cells. Among these, the interleukin 删除[酱]:
Keywords: Cytokines, Interleukins, Interleukin receptors, Inflammation, liver fibrosis
Received: 16 Sep 2024; Accepted: 22 Jan 2025.
Copyright: © 2025 Zixin, JIahui, Hui, Qun, Yujing, Xin, Zijian and Haijian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wang JIahui, School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Li Hui, Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
Niu Qun, Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
Tao Yujing, Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
Zhao Xin, Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
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