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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1510182
This article is part of the Research Topic Crosstalk in Tumor Microenvironments: Shaping Early Drug and Immunotherapy Strategies View all 3 articles

Stanniocalcin-1 in tumor immunity: acts via macrophages

Provisionally accepted
Lele Wang Lele Wang 1,2Jianjun Wang Jianjun Wang 2*Weijie Qiang Weijie Qiang 2*Weihong Ge Weihong Ge 2*
  • 1 Nanjing Drum Tower Hospital, Nanjing, China
  • 2 Department of Pharmacy, Nanjing Drum Tower Hospital, Nanjing, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Tumor immune escape has become a research hotspot in the filed of cancer immunotherapy. Tumorassociated macrophages (TAMs) are the key component of tumor microenvironment, which play a pivotal role in tumor immune escape by regulating the immunity checkpoints, inhibiting the activity of T lymphocytes and natural killer (NK) cells, and modulating proportion of different T cells.Stanniocalcin-1(STC1)is ubiquitously expressed in human body, which is proven to involve with tumor progression and clinical prognosis. Recently, STC1 is implicated in tumor microenvironment as a phagocytosis checkpoint, as well as regulates the immunity via macrophages. In the review, we discussed the role of STC1 and TAMs in tumor immunity and their crosstalk, hoping to provide references for the research of STC1 in tumor immunotherapy.

    Keywords: tumor immunity, Tumor-associated macrophages, Stanniocalcin-1, Immunotherapy, Tumor Microenvironment

    Received: 12 Oct 2024; Accepted: 06 Nov 2024.

    Copyright: © 2024 Wang, Wang, Qiang and Ge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jianjun Wang, Department of Pharmacy, Nanjing Drum Tower Hospital, Nanjing, 210008, Jiangsu Province, China
    Weijie Qiang, Department of Pharmacy, Nanjing Drum Tower Hospital, Nanjing, 210008, Jiangsu Province, China
    Weihong Ge, Department of Pharmacy, Nanjing Drum Tower Hospital, Nanjing, 210008, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.