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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1489444
This article is part of the Research Topic Formation of Immunological Niches in Tumor Microenvironments: Mechanisms and Therapeutic Potential View all 6 articles

Single-Cell Sequencing Unveils Mitophagy-Related Prognostic Model for Triple-Negative Breast Cancer

Provisionally accepted
培凯 丁 培凯 丁 1,2Pei Shengbin Pei Shengbin 1,2Zheng Qu Zheng Qu 1,2Yazhe Yang Yazhe Yang 1,2*Qiang Liu Qiang Liu 3*Xiangyi Kong Xiangyi Kong 1*Zhongzhao Wang Zhongzhao Wang 1*Jing Wang Jing Wang 1Yi Fang Yi Fang 1*
  • 1 National Cancer Center, Chinese Academy of Medical Sciences, Beijing, China
  • 2 Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, Beijing Municipality, China
  • 3 Department of Nutrition, School of Public Health, Harvard University, Boston, Massachusetts, United States

The final, formatted version of the article will be published soon.

    Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking hormone receptors and HER2 expression, leading to limited treatment options and poor prognosis. Mitophagy, a selective autophagy process targeting damaged mitochondria, plays a complex role in cancer progression, yet its prognostic significance in TNBC is not well understood.This study utilized single-cell RNA sequencing data from the TCGA and GEO databases to identify mitophagy-related genes (MRGs) associated with TNBC. A prognostic model was developed using univariate Cox analysis and LASSO regression. The model was validated across multiple independent cohorts, and correlations between MRG expression, immune infiltration, and drug sensitivity were explored.Nine key MRGs were identified and used to stratify TNBC patients into high-risk and low-risk groups, with the high-risk group showing significantly worse survival outcomes. The model demonstrated strong predictive accuracy across various datasets. Additionally, the study revealed a correlation between higher MRG expression levels and increased immune cell infiltration, as well as potential responsiveness to specific chemotherapeutic agents.The mitophagy-related prognostic model offers a novel method for predicting outcomes in TNBC patients and highlights the role of mitophagy in influencing the tumor microenvironment, with potential applications in personalized treatment strategies.

    Keywords: ： Triple-negative breast cancer, mitophagy, single-cell sequencing, Prognostic model, Immunoassay

    Received: 01 Sep 2024; Accepted: 11 Oct 2024.

    Copyright: © 2024 丁, Shengbin, Qu, Yang, Liu, Kong, Wang, Wang and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yazhe Yang, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, 100006, Beijing Municipality, China
    Qiang Liu, Department of Nutrition, School of Public Health, Harvard University, Boston, Massachusetts, United States
    Xiangyi Kong, National Cancer Center, Chinese Academy of Medical Sciences, Beijing, China
    Zhongzhao Wang, National Cancer Center, Chinese Academy of Medical Sciences, Beijing, China
    Yi Fang, National Cancer Center, Chinese Academy of Medical Sciences, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.