Skip to main content

REVIEW article

Front. Immunol.
Sec. T Cell Biology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1462384
This article is part of the Research Topic Regulatory Pathways Orchestrate T Cell Activity in Tumor Immunology and Organ Transplantation View all articles

The Role of Islet Autoantigen-Specific T Cells in the Onset and Treatment of Type 1 Diabetes Mellitus

Provisionally accepted
Mengmeng Yue Mengmeng Yue 1Xianzhen He Xianzhen He 2Xinwen Min Xinwen Min 1Handong Yang Handong Yang 1Hao Xu Hao Xu 1Wenwen Wu Wenwen Wu 3Jixin Zhong Jixin Zhong 4Aihua Mei Aihua Mei 1Jun Chen Jun Chen 1*
  • 1 Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, China
  • 2 Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China
  • 3 School of Public Health and Management, Hubei University of Medicine, Shiyan, Hubei, China
  • 4 Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China

The final, formatted version of the article will be published soon.

    Type 1 diabetes mellitus (T1DM), a complex chronic disease with an intricate etiology and pathogenesis, involves the recognition of self-antigens by pancreatic islet autoantigen-specific T cells and plays crucial roles in both early- and late-stage destruction of beta cells, thus impacting disease progression. Antigen-specific T cells regulate and execute immune responses by recognizing particular antigens, playing broad roles in the treatment of various diseases. Immunotherapy targeting antigen-specific T cells holds promising potential as a targeted treatment approach. This review outlines the pathogenesis of diabetes, emphasizing the pivotal role of pancreatic islet autoantigen-specific T cells in the progression and treatment of T1DM. Exploring this avenue in research holds promise for identifying novel therapeutic targets for effectively managing diabetes.

    Keywords: Type 1 Diabetes Mellitus1, Islet autoantigen2, Antigen-specific T cells3, T cell phenotype4, immunotherapy5

    Received: 10 Jul 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Yue, He, Min, Yang, Xu, Wu, Zhong, Mei and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jun Chen, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.