AUTHOR=Yue Mengmeng , He Xianzhen , Min Xinwen , Yang Handong , Xu Hao , Wu Wenwen , Zhong Jixin , Mei Aihua , Chen Jun TITLE=The role of islet autoantigen-specific T cells in the onset and treatment of type 1 diabetes mellitus JOURNAL=Frontiers in Immunology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1462384 DOI=10.3389/fimmu.2024.1462384 ISSN=1664-3224 ABSTRACT=

Type 1 diabetes mellitus (T1DM), a complex chronic disease with an intricate etiology and pathogenesis, involves the recognition of self-antigens by pancreatic islet autoantigen-specific T cells and plays crucial roles in both early- and late-stage destruction of beta cells, thus impacting disease progression. Antigen-specific T cells regulate and execute immune responses by recognizing particular antigens, playing broad roles in the treatment of various diseases. Immunotherapy targeting antigen-specific T cells holds promising potential as a targeted treatment approach. This review outlines the pathogenesis of diabetes, emphasizing the pivotal role of pancreatic islet autoantigen-specific T cells in the progression and treatment of T1DM. Exploring this avenue in research holds promise for identifying novel therapeutic targets for effectively managing diabetes.