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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1462174
This article is part of the Research Topic The Pathogenesis, Molecular Diagnosis and Targeted Therapy of Digestive System Carcinoma View all articles
AKR1B10 and Digestive Tumours Development: A Review
Provisionally accepted
Yao Shen
1
Ailin Qiu
2
Xing Huang
3
Xiaosha Wen
3
Sundar Ismail
3
Jian Zhang
1
Dixian Luo
3*
Shenghui Yang
1*- 1 School of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Anhui Province, China
- 2 School of Pharmaceutical Science, Hengyang Medical School, University of South China, Changsha, Hunan Province, China
- 3 Laboratory Medicine Centre, Shenzhen Nanshan People's Hospital, People’s Republic of China (Nanshan Hospital), Shenzhen University, Shenzhen, Guangdong, China, Shenzhen, China
Aldo-keto reductase family 1 member B10 (AKR1B10) is a member of the AKR1B subfamily., It is mainly found in the cytoplasm, and it is typically expressed in the stomach and intestines. Its Given that its expression is low or absent in other tissues, making AKR1B10 is a potential diagnostic and therapeutic biomarker for various digestive system diseases. In this paperHere, we review the recent research progress on AKR1B10 in digestive system tumors such as hepatocellular carcinoma, gastric carcinoma, colorectal carcinoma, pancreatic carcinoma, oral squamous cell carcinoma, laryngeal squamous cell carcinoma, cholangiocarcinoma, and nasopharyngeal carcinoma, over the past last 5 years. We also discuss the current trends and future research directions for AKR1B10 in both oncological and non-oncological diseases to provide a scientific reference for further exploration of this gene.
Keywords: AKR1B10, Metabolism, mechanisms, review, Digestive system tumors
Received: 09 Jul 2024; Accepted: 26 Nov 2024.
Copyright: © 2024 Shen, Qiu, Huang, Wen, Ismail, Zhang, Luo and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dixian Luo, Laboratory Medicine Centre, Shenzhen Nanshan People's Hospital, People’s Republic of China (Nanshan Hospital), Shenzhen University, Shenzhen, Guangdong, China, Shenzhen, China
Shenghui Yang, School of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, Anhui Province, China
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