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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Microbial Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1444778

Prevention and Alleviation of Allergic Rhinitis by oral administration of Lacticaseibacillus paracasei GOLDGUT-Lpc969

Provisionally accepted
Xiaoli Zhou Xiaoli Zhou 1Xizi SONG Xizi SONG 2Ting Shu Ting Shu 1Silu Zhang Silu Zhang 1Zhizhu Zhang Zhizhu Zhang 1Canying Hu Canying Hu 2Jie Pan Jie Pan 2Xiaoshuang Dai Xiaoshuang Dai 2Huaijiie Hao Huaijiie Hao 2Guoxun Xiao Guoxun Xiao 1*Wang Pengfei Wang Pengfei 3*Kai Liu Kai Liu 4*
  • 1 Wonderlab Innovation Centre for Healthcare, Shenzhen Porshealth Bioengineering Co.,Ltd, Shenzhen, China
  • 2 Shenzhen Xbiome Biotech Co., Ltd., Shenzhen, China
  • 3 Sun Yat-sen Memorial Hospital, Guangzhou, Guangdong Province, China
  • 4 The University of Rehabilitation, Qingdao, Shandong Province, China

The final, formatted version of the article will be published soon.

    Allergic rhinitis (AR) is a widespread upper-airway disorder characterized by inflammation of the nasal passages. It is immunologically mediated via the hypersensitivity type I mechanism, which is primarily elicited by the immunoglobulin E (IgE)-linking allergen-induced imbalance of Th2/Th1 immune response. Due to limited efficacy of current medications, probiotics have received attention for their potential in preventing and ameliorating AR. In this study, a Lacticaseibacillus paracasei strain GOLDGUT-Lpc969 (Lpc969), isolated from feces of healthy adults, had been proved to be effective in preventing AR. The strain significantly attenuated the release of histamine and degranulation in LPS-induced RBL-2H3 cells. While in the OVA-induced AR mice, L. paracasei GOLDGUT-Lpc969 also exhibited significant decrease on the disease indicators such as disease activity index (DAI score), serum IgE, and serum histamine. Treatment with L. paracasei GOLDGUT-Lpc969 led to significant suppression of Th2-related cytokines IL-4, IL-5, IL-6, IL-13 and TNF-α in the serum of mice. Furthermore, a comparison of the genomes of three previously reported AR-effective L. paracasei strains (including GOLDGUT-Lpc969) and one non-effective L. paracasei strain revealed that the gene K03671 may play a key role in alleviating AR symptoms. In conclusion, this study highlights the efficacy of L. paracasei GOLDGUT-Lpc969 in AR prevention through suppressing Th2 immune response and proposes the potential involvement of the functional gene K03671 in ameliorating AR symptoms. Therefore, L. paracasei GOLDGUT-Lpc969 shows promise as a probiotic for preventing AR.

    Keywords: allergic rhinitis, Lacticaseibacillus paracasei, Th2 immune response, probiotic, Immunomodulation, Gene K03671

    Received: 12 Jun 2024; Accepted: 05 Sep 2024.

    Copyright: © 2024 Zhou, SONG, Shu, Zhang, Zhang, Hu, Pan, Dai, Hao, Xiao, Pengfei and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Guoxun Xiao, Wonderlab Innovation Centre for Healthcare, Shenzhen Porshealth Bioengineering Co.,Ltd, Shenzhen, China
    Wang Pengfei, Sun Yat-sen Memorial Hospital, Guangzhou, 510000, Guangdong Province, China
    Kai Liu, The University of Rehabilitation, Qingdao, Shandong Province, China

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