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REVIEW article

Front. Immunol.
Sec. Systems Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1444253

Liquid-liquid phase separation: A new perspective on respiratory diseases

Provisionally accepted
Li Wang Li Wang 1Yongjun Wang Yongjun Wang 2Zhangmin Ke Zhangmin Ke 2Zexu Wang Zexu Wang 2Yufang Guo Yufang Guo 2Yunlei Zhang Yunlei Zhang 2Xiuwei Zhang Xiuwei Zhang 2Zhongliang Guo Zhongliang Guo 3*Bing Wan Bing Wan 2*
  • 1 Other, Department of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China
  • 2 Department of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China
  • 3 Shanghai East Hospital of Clinical Medical College, Nanjing Medical University, Shanghai, China

The final, formatted version of the article will be published soon.

    Liquid-liquid phase separation (LLPS) is integral to various biological processes, facilitating signal transduction by creating a condensed, membrane-less environment that plays crucial roles in diverse physiological and pathological processes. Recent evidence has underscored the significance of LLPS in human health and disease. However, its implications in respiratory diseases remain poorly understood. This review explores current insights into the mechanisms and biological roles of LLPS, focusing particularly on its relevance to respiratory diseases, aiming to deepen our understanding and propose a new paradigm for studying phase separation in this context.

    Keywords: Liquid-liquid phase separation, membrane-less organelle, biomolecular condensates, Respiratory diseases, Lung

    Received: 05 Jun 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Wang, Wang, Ke, Wang, Guo, Zhang, Zhang, Guo and Wan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhongliang Guo, Shanghai East Hospital of Clinical Medical College, Nanjing Medical University, Shanghai, China
    Bing Wan, Department of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.