AUTHOR=Wang Li , Wang Yongjun , Ke Zhangmin , Wang Zexu , Guo Yufang , Zhang Yunlei , Zhang Xiuwei , Guo Zhongliang , Wan Bing 

TITLE=Liquid-liquid phase separation: a new perspective on respiratory diseases

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1444253

DOI=10.3389/fimmu.2024.1444253

ISSN=1664-3224

ABSTRACT=<p>Liquid-liquid phase separation (LLPS) is integral to various biological processes, facilitating signal transduction by creating a condensed, membrane-less environment that plays crucial roles in diverse physiological and pathological processes. Recent evidence has underscored the significance of LLPS in human health and disease. However, its implications in respiratory diseases remain poorly understood. This review explores current insights into the mechanisms and biological roles of LLPS, focusing particularly on its relevance to respiratory diseases, aiming to deepen our understanding and propose a new paradigm for studying phase separation in this context.</p>