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REVIEW article

Front. Immunol.
Sec. Vaccines and Molecular Therapeutics
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1436108

Towards Personalized Vaccines

Provisionally accepted
Davide Montin Davide Montin 1*Veronica Santilli Veronica Santilli 2Alessandra Beni Alessandra Beni 3Giorgio Costagliola Giorgio Costagliola 4Baldassarre Martire Baldassarre Martire 5Maria F. Mastrototaro Maria F. Mastrototaro 5Giorgio Ottaviano Giorgio Ottaviano 6Caterina Rizzo Caterina Rizzo 7Mayla Sgrulletti Mayla Sgrulletti 8Michele Miraglia Del Giudice Michele Miraglia Del Giudice 9Viviana Moschese Viviana Moschese 8
  • 1 Regina Margherita Hospital, Turin, Italy
  • 2 Bambino Gesù Children's Hospital (IRCCS), Rome, Lazio, Italy
  • 3 Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Tuscany, Italy
  • 4 Unità di Ematologia Pediatrica, Azienda Ospedaliero Universitaria Pisana, Pisa, Tuscany, Italy
  • 5 Unit of Pediatrics and Neonatology, “Monsignor A.R. Dimiccoli” Hospital, Barletta, Italy, Barletta, Italy
  • 6 Department of Pediatrics, IRCCS San Gerardo dei Tintori Foundation, Rome, Sicily, Italy
  • 7 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Tuscany, Italy
  • 8 Pediatric Immunopathology and Allergology Unit, University of Rome Tor Vergata, Roma, Lazio, Italy
  • 9 Department of Women, Children And General and Specialist Surgery, University of Campania Luigi Vanvitelli, Naples, Campania, Italy

The final, formatted version of the article will be published soon.

    The emergence of vaccinomics and system vaccinology represents a transformative shift in immunization strategies, advocating for personalized vaccines tailored to individual genetic and immunological profiles. Integrating insights from genomics, transcriptomics, proteomics, and immunology, personalized vaccines offer the promise of enhanced efficacy and safety, revolutionizing the field of vaccinology. However, the development of personalized vaccines presents multifaceted challenges, including technical, ethical, economic, and regulatory considerations. Addressing these challenges is essential to ensure equitable access and safety of personalized vaccination strategies. Despite these hurdles, the potential of personalized vaccines to optimize responses and mitigate disease burden underscores the significance of ongoing research and collaboration in advancing precision medicine in immunization.

    Keywords: Vaccines, Vaccinomics and personalized vaccines, System vaccinology, Proteomics, Genomics, Transcriptomics, Precision Medicine

    Received: 21 May 2024; Accepted: 18 Sep 2024.

    Copyright: © 2024 Montin, Santilli, Beni, Costagliola, Martire, Mastrototaro, Ottaviano, Rizzo, Sgrulletti, Miraglia Del Giudice and Moschese. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Davide Montin, Regina Margherita Hospital, Turin, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.