AUTHOR=Montin Davide , Santilli Veronica , Beni Alessandra , Costagliola Giorgio , Martire Baldassarre , Mastrototaro Maria Felicia , Ottaviano Giorgio , Rizzo Caterina , Sgrulletti Mayla , Miraglia Del Giudice Michele , Moschese Viviana TITLE=Towards personalized vaccines JOURNAL=Frontiers in Immunology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1436108 DOI=10.3389/fimmu.2024.1436108 ISSN=1664-3224 ABSTRACT=

The emergence of vaccinomics and system vaccinology represents a transformative shift in immunization strategies, advocating for personalized vaccines tailored to individual genetic and immunological profiles. Integrating insights from genomics, transcriptomics, proteomics, and immunology, personalized vaccines offer the promise of enhanced efficacy and safety, revolutionizing the field of vaccinology. However, the development of personalized vaccines presents multifaceted challenges, including technical, ethical, economic, and regulatory considerations. Addressing these challenges is essential to ensure equitable access and safety of personalized vaccination strategies. Despite these hurdles, the potential of personalized vaccines to optimize responses and mitigate disease burden underscores the significance of ongoing research and collaboration in advancing precision medicine in immunization.