Skip to main content

ORIGINAL RESEARCH article

Front. Immunol.
Sec. Molecular Innate Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1431633
This article is part of the Research Topic Immunesenescence in Innate Immune Cells and Disease Development View all 4 articles

Dectin-1 participates in the immune-inflammatory response to mouse Aspergillus fumigatus keratitis by modulating macrophage polarization

Provisionally accepted
Liu Guibo Liu Guibo 1*Dong Chunxu Dong Chunxu 2,3Chen Biao Chen Biao 3*Hu Zhaolei Hu Zhaolei 3*Liu Wenwen Liu Wenwen 3*Ji Xiangnan Ji Xiangnan 3*Peng Wentao Peng Wentao 2,3*Chang Hongmin Chang Hongmin 2,3*Li Yonghua Li Yonghua 3*Zhu Guoqiang Zhu Guoqiang 3*
  • 1 Qingdao University, Qingdao, Shandong Province, China
  • 2 Jining Medical University, Jining, Shandong, China
  • 3 Affiliated Hospital of Jining Medical University, Jining, China

The final, formatted version of the article will be published soon.

    Fungal keratitis (FK) is a severe corneal disease that may cause vision loss. Previous studies indicate that the innate immune response produces the most effective anti-Aspergillus immune resistance. Dectin-1, a pattern-recognition receptor (PRR) family plays an important role in the innate immune response of fungal keratitis. In this study, we aimed to further explore the role of Dectin-1 in the A. fumigatus infected cornea. Our study revealed that Dectin-1 regulates macrophage recruitment and polarization and plays a key role in corneal antifungal innate immunity. Our study also revealed that Dectin-1 may regulate changes in macrophage phenotype-associated factors through the MAPK cell signaling pathway.

    Keywords: Fungal keratitis, dectin-1, innate immune response, macrophage, polarization

    Received: 12 May 2024; Accepted: 25 Sep 2024.

    Copyright: © 2024 Guibo, Chunxu, Biao, Zhaolei, Wenwen, Xiangnan, Wentao, Hongmin, Yonghua and Guoqiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Liu Guibo, Qingdao University, Qingdao, 266071, Shandong Province, China
    Chen Biao, Affiliated Hospital of Jining Medical University, Jining, China
    Hu Zhaolei, Affiliated Hospital of Jining Medical University, Jining, China
    Liu Wenwen, Affiliated Hospital of Jining Medical University, Jining, China
    Ji Xiangnan, Affiliated Hospital of Jining Medical University, Jining, China
    Peng Wentao, Jining Medical University, Jining, 272067, Shandong, China
    Chang Hongmin, Jining Medical University, Jining, 272067, Shandong, China
    Li Yonghua, Affiliated Hospital of Jining Medical University, Jining, China
    Zhu Guoqiang, Affiliated Hospital of Jining Medical University, Jining, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.