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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Molecular Innate Immunity
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1431633
This article is part of the Research Topic Immunesenescence in Innate Immune Cells and Disease Development View all 4 articles
Dectin-1 participates in the immune-inflammatory response to mouse Aspergillus fumigatus keratitis by modulating macrophage polarization
Provisionally accepted- 1 Qingdao University, Qingdao, Shandong Province, China
- 2 Jining Medical University, Jining, Shandong, China
- 3 Affiliated Hospital of Jining Medical University, Jining, China
Fungal keratitis (FK) is a severe corneal disease that may cause vision loss. Previous studies indicate that the innate immune response produces the most effective anti-Aspergillus immune resistance. Dectin-1, a pattern-recognition receptor (PRR) family plays an important role in the innate immune response of fungal keratitis. In this study, we aimed to further explore the role of Dectin-1 in the A. fumigatus infected cornea. Our study revealed that Dectin-1 regulates macrophage recruitment and polarization and plays a key role in corneal antifungal innate immunity. Our study also revealed that Dectin-1 may regulate changes in macrophage phenotype-associated factors through the MAPK cell signaling pathway.
Keywords: Fungal keratitis, dectin-1, innate immune response, macrophage, polarization
Received: 12 May 2024; Accepted: 25 Sep 2024.
Copyright: © 2024 Guibo, Chunxu, Biao, Zhaolei, Wenwen, Xiangnan, Wentao, Hongmin, Yonghua and Guoqiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Liu Guibo, Qingdao University, Qingdao, 266071, Shandong Province, China
Chen Biao, Affiliated Hospital of Jining Medical University, Jining, China
Hu Zhaolei, Affiliated Hospital of Jining Medical University, Jining, China
Liu Wenwen, Affiliated Hospital of Jining Medical University, Jining, China
Ji Xiangnan, Affiliated Hospital of Jining Medical University, Jining, China
Peng Wentao, Jining Medical University, Jining, 272067, Shandong, China
Chang Hongmin, Jining Medical University, Jining, 272067, Shandong, China
Li Yonghua, Affiliated Hospital of Jining Medical University, Jining, China
Zhu Guoqiang, Affiliated Hospital of Jining Medical University, Jining, China
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