AUTHOR=Guibo Liu , Chunxu Dong , Biao Chen , Zhaolei Hu , Wenwen Liu , Xiangnan Ji , Wentao Peng , Hongmin Chang , Yonghua Li , Guoqiang Zhu 

TITLE=Dectin-1 participates in the immune-inflammatory response to mouse Aspergillus fumigatus keratitis by modulating macrophage polarization

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1431633

DOI=10.3389/fimmu.2024.1431633

ISSN=1664-3224

ABSTRACT=Fungal keratitis (FK) is a severe corneal disease that may cause vision loss. Previous studies indicate that the innate immune response produces the most effective anti-Aspergillus immune resistance. Dectin-1, a pattern-recognition receptor (PRR) family plays an important role in the innate immune response of fungal keratitis. In this study, we aimed to further explore the role of Dectin-1 in the A. fumigatus infected cornea. Our study revealed that Dectin-1 regulates macrophage recruitment and polarization and plays a key role in corneal antifungal innate immunity. Our study also revealed that Dectin-1 may regulate changes in macrophage phenotype-associated factors through the MAPK cell signaling pathway.