Frontiers in Genetics | Genetics of Common and Rare Diseases

Original Research

Accepted on 22 Apr 2025

Unveiling the Molecular Landscape of δ-thalassemia and δ-globin variants in Southern China: Novel Mutations, gene spectrum, and Implications for Thalassemia Diagnosis

in Genetics of Common and Rare Diseases

Youqiong Li
Lihua Ye
Liang Liang
Lihong Zheng
Yongjun Xiao
Zhongchan Lao
Jinping Bai
Xi He
Qixun Fang
Ting Qin

Frontiers in Genetics

doi 10.3389/fgene.2025.1584310

Original Research

Accepted on 22 Apr 2025

Identification of Candidate Genes Harboring Pathogenic Variants in Congenital Heart Disease and Laterality Defects in Chinese population

in Genetics of Common and Rare Diseases

Jinxin Wang
Weicheng Chen
Xianghui Huang
Han Gao
Zhiyu Feng
Chaozhong Tan
Quannan Zhuang
YUAN GAO
Shaojie Min
Yuquan Lu

Frontiers in Genetics

doi 10.3389/fgene.2025.1582718

Original Research

Accepted on 22 Apr 2025

Clinical Features and Genetic Analysis of a Family with t(5;9)(p15;p24) Balanced Translocation Leading to Cri-du-chat Syndrome in Offspring

in Genetics of Common and Rare Diseases

Jing Zhao
Ping Chen
Yijia Ren
Shurong Li
Weiyi Zhang
Yan Li
Fengyu Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1550937

Case Report

Published on 22 Apr 2025

Case report: a case of hypoparathyroidism–sensorineural deafness–renal dysplasia syndrome

in Genetics of Common and Rare Diseases

Jinyan Yang
Yanjie Mei
Feifei Tang
Xinhong Guo
Yanhua Kong
Ying Deng

Frontiers in Genetics

doi 10.3389/fgene.2025.1501427

194 views

Original Research

Published on 22 Apr 2025

Novel ACAD8 variants identified in Isobutyryl-CoA dehydrogenase deficiency: challenges in phenotypic variability and management

in Genetics of Common and Rare Diseases

Yilun Tao
Dong Han
Jianfang Li
Xiaoyun Li
Luna Hao
Wenxia Song
Lihong Wang
Xiaoze Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1532902

219 views

Brief Research Report

Accepted on 21 Apr 2025

Complete defect in PA-PLA1α secretion function leading to autosomal recessive woolly hair and hypotrichosis: insights from a novel compound heterozygous LIPH variant study in a Chinese pedigree

in Genetics of Common and Rare Diseases

Xinyue Zhang
Kexin Guo
JiaWei Liu
Xueting Yang
Rui Zhang
Rongrong Wang
Dong-Lai Ma
Xue Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1591409

Case Report

Accepted on 17 Apr 2025

Autosomal Recessive Primary Microcephaly in Sibs in Time of Zika Epidemic: A Case Report

in Genetics of Common and Rare Diseases

Julia Valeriano de Almeida
Natana Chaves Rabelo
Bianca Barbosa Abdala
Juan Clinton Llerena Junior
Sayonara Gonzalez

Frontiers in Genetics

doi 10.3389/fgene.2025.1565296

Case Report

Published on 17 Apr 2025

CEBPA-associated familial acute myeloid leukemia mimicking Werner syndrome: a case report

in Genetics of Common and Rare Diseases

Tanguy Demaret
Damien Feret
Barbara Lambert
Delphine Pranger
Jean-Louis Dargent
Maria Dolores Martin Martinez
Antonio Renda
Isabelle Maystadt

Frontiers in Genetics

doi 10.3389/fgene.2025.1575651

329 views

Original Research

Published on 17 Apr 2025

Identification of a novel homozygous SLC13A5 nonstop mutation in a Chinese family with epileptic encephalopathy and developmental delay

in Genetics of Common and Rare Diseases

Hua He
Lijuan Long
Manling Tang
Qiang Xu
Shengwu Duan
Ge Chen
Yan Zhao
Qiongfang Wu
Jia Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1474390

386 views

Case Report

Published on 17 Apr 2025

Estrogen-secreting testicular tumors in 46,XY female patients with 17α-hydroxylase/17,20-lyase deficiency: two unusual case reports and a review of the literature

in Genetics of Common and Rare Diseases

Julio Americo Pereira Batatinha
Mirian Yumie Nishi
Rafael Loch Batista
José Antônio Diniz Faria Júnior
Maria Helena Palma Sircili
Francisco Tibor Denes
Maria Jimena Chafloque Mesia
Laura da Silva Salvanini
Elaine Maria Frade Costa
Filomena Marino Carvalho

Frontiers in Genetics

doi 10.3389/fgene.2025.1508792

354 views

Original Research

Accepted on 16 Apr 2025

Relationship of VDR and VDBP gene polymorphisms with sepsis susceptibility and prognosis

in Genetics of Common and Rare Diseases

Chan Lian
Kangtai Ying
Haiyan Shao
Haiting Gu
Wenwei Mao

Frontiers in Genetics

doi 10.3389/fgene.2025.1590750

Case Report

Published on 16 Apr 2025

A novel SIGMAR1 missense mutation leads to distal hereditary motor neuropathy phenotype mimicking juvenile ALS: a case report of China

in Genetics of Common and Rare Diseases

Qinglong Yu
Risna Begam Mohammed Nazar
Sihui Chen
Qiaoling Qian
Junhui Wang
Xueping Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1477518

341 views

Case Report

Published on 11 Apr 2025

A novel nonsense mutation in SCAF4 associated with fliedner-zweier syndrome: a case report and review of the literature

in Genetics of Common and Rare Diseases

Zhengfang Chen
Jing Zhao
Xiaoxuan Fan
Xiaoyan Xuan
Xiaoke Zhao

Frontiers in Genetics

doi 10.3389/fgene.2025.1487352

360 views

Correction

Published on 11 Apr 2025

Corrigendum: Application of rapid clinical exome sequencing technology in the diagnosis of critically ill pediatric patients with suspected genetic diseases

in Genetics of Common and Rare Diseases

Xuejun Ouyang
Dazhi Chi
Yu Zhang
Tian Yu
Qian Zhang
Lei Xu
Victor Wei Zhang
Bin Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1592212

325 views

Original Research

Published on 11 Apr 2025

Identification of cellular senescence-related genes as biomarkers for lupus nephritis based on bioinformatics

in Genetics of Common and Rare Diseases

Wei Chen
Xiaofang Wang
Guoshun Huang
Qin Sheng
Enchao Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1551450

355 views

Original Research

Accepted on 10 Apr 2025

Identification of potential crucial genes and mechanisms associated with Metabolically Unhealthy Obesity based on gene expression profile

in Genetics of Common and Rare Diseases

Qingqing Wang
丝露王
Zhanyu Zhuang
Xueting Wu
Hongkun Gao
Tianyi Zhang
Guorong Zou
Xing Ge
Yapeng Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1540721