Frontiers in Genetics | Computational Genomics

Original Research

Accepted on 25 Feb 2025

Mechanism of action and experimental validation of key genes common to diabetic retinopathy and coronary heart disease based on multiple bioinformatics investigations

in Computational Genomics

Fanli Jiang
Shi Yin
Xinjin Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1548147

Original Research

Accepted on 24 Feb 2025

A semi-supervised weighted SPCA and convolution KANs based Drug response prediction model

in Computational Genomics

Rui Miao
Bing-Jie Zhong
Xin-Yue Mei
Xin Dong
Yang-Dong Ou
Yong Liang
Hao-Yang Yu
Ying Wang
Zi-Han Dong

Frontiers in Genetics

doi 10.3389/fgene.2025.1532651

Original Research

Accepted on 24 Feb 2025

MDNN-DTA: a multimodal deep neural network for drug-target affinity prediction

in Computational Genomics

Xu Gao
Mengfan Yan
Chengwei Zhang
Gang Wu
Jiandong Shang
Congxiang Zhang
Kecheng Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1527300

Editorial

Accepted on 24 Feb 2025

Editorial: The role of genes and network pharmacology in new drug discovery

in Computational Genomics

Jingxin Mao

Frontiers in Genetics

doi 10.3389/fgene.2025.1578094

Original Research

Published on 24 Feb 2025

Exploring the underlying molecular connections: a bioinformatics approach to link melanoma and Parkinson’s disease

in Computational Genomics

Limei Zhang
Dailin Li
Xu Zheng
Moli Wu
Qijun Yao
Haoran Chen
Zhiqiang Ye
Bo Yuan

Frontiers in Genetics

doi 10.3389/fgene.2025.1526018

187 views

Original Research

Accepted on 21 Feb 2025

CLMT: Graph Contrastive Learning Model for Microbe-Drug Associations Prediction with Transformer

in Computational Genomics

Liqi Xiao
Junlong Wu
Liu Fan
Lei Wang
Xianyou Zhu

Frontiers in Genetics

doi 10.3389/fgene.2025.1535279

Editorial

Published on 21 Feb 2025

Editorial: Integrative genetics and multi-omics of complex human disorders

in Computational Genomics

Hongsheng Gui
Christopher J. Lessard
Jinhui Liu
Miaoxin Li
Indra Adrianto

Frontiers in Genetics

doi 10.3389/fgene.2025.1574431

243 views

Original Research

Published on 21 Feb 2025

Comprehensive analysis of non-coding RNA-mediated endothelial cell-specific regulatory circuits in coronary artery disease risk

in Computational Genomics

Boshui Huang
Zhijie Lai
Xiaoyu Wang
Qinhao Zhang
Tingting Hu
Fulong Yu
Shuxian Zhou
Yan Zhang
Juan Meng

Frontiers in Genetics

doi 10.3389/fgene.2025.1559798

212 views

Original Research

Accepted on 20 Feb 2025

De novo KCNK4 variant caused epilepsy with febrile seizures plus, neurodevelopmental abnormalities, and hypertrichosis

in Computational Genomics

Hong-Jun Yan
Wenhui Liu
Min-Xing Xu
Peng-Yu Wang
Yu-Jie Gu
Hua Li
Sheng Luo

Frontiers in Genetics

doi 10.3389/fgene.2025.1499716

Original Research

Accepted on 20 Feb 2025

Cancer Classification in High Dimensional Microarray Gene Expressions by Feature Selection using Eagle Prey Optimization

in Computational Genomics

Swetha Dhamercherla
Damodar Reddy Edla
Suresh Dara

Frontiers in Genetics

doi 10.3389/fgene.2025.1528810

Original Research

Published on 20 Feb 2025

EDN1 and NTF3 in keloid pathogenesis: computational and experimental evidence as novel diagnostic biomarkers for fibrosis and inflammation

in Computational Genomics

Hui Gong
Jing Liu
Nanji Chen
Hengguang Zhao
Bailin He
Hongpei Zhang
Wenping Wang
Yi Tian

Frontiers in Genetics

doi 10.3389/fgene.2025.1516451

238 views

Methods

Published on 17 Feb 2025

WCSGNet: a graph neural network approach using weighted cell-specific networks for cell-type annotation in scRNA-seq

in Computational Genomics

Yi-Ran Wang
Pu-Feng Du

Frontiers in Genetics

doi 10.3389/fgene.2025.1553352

301 views

Original Research

Accepted on 13 Feb 2025

Role of lactylation and Immune Infiltration in Atherosclerosis: Novel Insights from Bioinformatics Analyses

in Computational Genomics

Jintao Qian
Qing Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1520325

Original Research

Accepted on 11 Feb 2025

Exploring the Oncogenic Role and Prognostic Value of CKS1B in Human Lung Adenocarcinoma and Squamous Cell Carcinoma

in Computational Genomics

Md Solayman Hossain
Tariqul Islam Tusar
Nairita Ahsan Faruqui
Tanjim Ishraq Rahaman
Yasin Arafath Sharker
Shimran Saharia Santo
Abu Tayab Moin
Yusha Araf
Ibrahim Khalil Afif
Shoaib Saikat

Frontiers in Genetics

doi 10.3389/fgene.2025.1449466

Original Research

Published on 11 Feb 2025

Dual graph-embedded fusion network for predicting potential microbe-disease associations with sequence learning

in Computational Genomics

Junlong Wu
Liqi Xiao
Liu Fan
Lei Wang
Xianyou Zhu

Frontiers in Genetics

doi 10.3389/fgene.2025.1511521

295 views

Data Report

Published on 10 Feb 2025

Exploring the taxonomical and functional profiles of marine microorganisms in Submarine Groundwater Discharge vent water from Mabini, Batangas, Philippines through metagenome-assembled genomes

in Computational Genomics

Joshua T. Veluz
Laurence Anthony N. Mallari
Paul Christian T. Gloria
Maria Auxilia T. Siringan

Frontiers in Genetics

doi 10.3389/fgene.2025.1522253

629 views

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Articles

Mechanism of action and experimental validation of key genes common to diabetic retinopathy and coronary heart disease based on multiple bioinformatics investigations

A semi-supervised weighted SPCA and convolution KANs based Drug response prediction model

MDNN-DTA: a multimodal deep neural network for drug-target affinity prediction

Editorial: The role of genes and network pharmacology in new drug discovery

Exploring the underlying molecular connections: a bioinformatics approach to link melanoma and Parkinson’s disease

CLMT: Graph Contrastive Learning Model for Microbe-Drug Associations Prediction with Transformer

Editorial: Integrative genetics and multi-omics of complex human disorders

Comprehensive analysis of non-coding RNA-mediated endothelial cell-specific regulatory circuits in coronary artery disease risk

De novo KCNK4 variant caused epilepsy with febrile seizures plus, neurodevelopmental abnormalities, and hypertrichosis

Cancer Classification in High Dimensional Microarray Gene Expressions by Feature Selection using Eagle Prey Optimization

EDN1 and NTF3 in keloid pathogenesis: computational and experimental evidence as novel diagnostic biomarkers for fibrosis and inflammation

WCSGNet: a graph neural network approach using weighted cell-specific networks for cell-type annotation in scRNA-seq

Role of lactylation and Immune Infiltration in Atherosclerosis: Novel Insights from Bioinformatics Analyses

Exploring the Oncogenic Role and Prognostic Value of CKS1B in Human Lung Adenocarcinoma and Squamous Cell Carcinoma

Dual graph-embedded fusion network for predicting potential microbe-disease associations with sequence learning

Exploring the taxonomical and functional profiles of marine microorganisms in Submarine Groundwater Discharge vent water from Mabini, Batangas, Philippines through metagenome-assembled genomes