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REVIEW article

Front. Endocrinol.
Sec. Gut Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1500336
This article is part of the Research Topic The Mechanism in Gut Microbiota of Diabetes and Endocrine Complications: Preventive and Therapeutic Target View all 8 articles

Protein-Bound Uremic Toxins as Therapeutic Targets for Cardiovascular, Kidney, and Metabolic Disorders

Provisionally accepted
Shihan Zhang Shihan Zhang Shasha Tang Shasha Tang *Yalei Liu Yalei Liu Binghua Xue Binghua Xue *Qinyuan Xie Qinyuan Xie *Lingyun Zhao Lingyun Zhao *Yuan Huijuan Yuan Huijuan *
  • Department of Endocrinology, Henan Province People’s Hospital, Zhengzhou, China

The final, formatted version of the article will be published soon.

    Cardiovascular-kidney-metabolic (CKM) syndrome is a systemic clinical condition characterized by pathological and physiological interactions among metabolic abnormalities, chronic kidney disease, and cardiovascular diseases, leading to multi-organ dysfunction and a higher incidence of cardiovascular endpoints. Traditional approaches to managing CKM syndrome risk are inadequate in these patients, necessitating strategies targeting specific CKM syndrome risk factors. Increasing evidence suggests that addressing uremic toxins and/or pathways induced by uremic toxins may reduce CKM syndrome risk and treat the disease. This review explores the interactions among heart, kidney, and metabolic pathways in the context of uremic toxins and underscores the significant role of uremic toxins as potential therapeutic targets in the pathophysiology of these diseases. Strategies aimed at regulating these uremic toxins offer potential avenues for reversing and managing CKM syndrome, providing new insights for its clinical diagnosis and treatment.

    Keywords: Protein-bound uremic toxins, Gut Microbiota, cardiovascular-kidney-metabolic syndrome, Metabolic Diseases, Management

    Received: 23 Sep 2024; Accepted: 02 Jan 2025.

    Copyright: © 2025 Zhang, Tang, Liu, Xue, Xie, Zhao and Huijuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shasha Tang, Department of Endocrinology, Henan Province People’s Hospital, Zhengzhou, China
    Binghua Xue, Department of Endocrinology, Henan Province People’s Hospital, Zhengzhou, China
    Qinyuan Xie, Department of Endocrinology, Henan Province People’s Hospital, Zhengzhou, China
    Lingyun Zhao, Department of Endocrinology, Henan Province People’s Hospital, Zhengzhou, China
    Yuan Huijuan, Department of Endocrinology, Henan Province People’s Hospital, Zhengzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.