Skip to main content

REVIEW article

Front. Endocrinol.
Sec. Cellular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1484829
This article is part of the Research Topic The Interplay between Endocrine and Immune Systems in Metabolic Diseases, Volume II View all articles

NOD1: A metabolic modulator

Provisionally accepted
Ruobing Tang Ruobing Tang 1Chunguang Xie Chunguang Xie 1,2,3*Xiyu Zhang Xiyu Zhang 1,2,3*
  • 1 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
  • 2 TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu, Sichuan, China
  • 3 Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China

The final, formatted version of the article will be published soon.

    Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular pattern recognition receptor that detects injury signals and initiates inflammatory responses and host defense. Furthermore, NOD1 serves as a metabolic mediator by influencing the metabolism of various tissues, including adipose tissue, liver, cardiovascular tissue, pancreatic β cells, adrenal glands, and bones through diverse mechanisms. It has been discovered that activated NOD1 is associated with the pathological mechanisms of certain metabolic diseases. This review presents a comprehensive summary of the impact of NOD1 on tissue-specific metabolism.

    Keywords: NOD1, Metabolism, endocrine, Inflammation, Immunity

    Received: 22 Aug 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Tang, Xie and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chunguang Xie, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
    Xiyu Zhang, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.