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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Neuroendocrine Science
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1443880

Neuron stress-related genes serve as newbiomarkers in hypothalamic tissue following high fat diet

Provisionally accepted
Caixia Liang Caixia Liang 1,2,3,4*Hongjian Lu Hongjian Lu 5*Xueqin Wang Xueqin Wang 6Jian-bin Su Jian-bin Su 6Feng Qi Feng Qi 7Yanxing Shang Yanxing Shang 1,2,3,4*Yu Li Yu Li 8*Dongmei Zhang Dongmei Zhang 1,2,3,4,8*Chengwei Duan Chengwei Duan 1,2,3,4*
  • 1 Medical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, China
  • 2 Jiangsu Provincial Medical Key Discipline (Laboratory) Cultivation Unit, Medical Research Center, Nantong First People’s Hospital, Nantong, China
  • 3 Nantong Municipal Medical Key Laboratory of Molecular Immunology, Medical Research Center, Nantong First People’s Hospital, Nantong, China
  • 4 Nantong Municipal Key Laboratory of Metabolic Immunology and Disease Microenvironment, Medical Research Center, Nantong First People’s Hospital, Nantong, China
  • 5 Other, Nantong, China
  • 6 Department of Endocrinology, Affiliated Hospital 2 of Nantong University, Nantong, China
  • 7 Emergency Intensive Care Unit, Affiliated Hospital 2 of Nantong University and First People's Hospital of Nantong City, Nantong, China
  • 8 Department of Pathogen Biology, Medical College, Nantong University, Nantong, China

The final, formatted version of the article will be published soon.

    Objective: Energy homeostasis is modulated by the hypothalamic is essential for obesity progression, however, the gene expression profiling remains to be fully understood.Methods: GEO datasets were downloaded from the GEO website and analysed by the R packages to obtain the DEGs. And, the WGCNA analysis and PPI networks of co-expressed DEGs were designed using STRING to get key genes. In addition, the single-cell sequencing datasets and GTEx database were utilized to receive the neuron-stress genes from the key genes. Further, high-fat diet (HFD)-induced hypothalamic tissue of mice was

    Keywords: Obesity, Neuron stress, hypothalamic inflammation, BMI1, WGCNA

    Received: 04 Jun 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Liang, Lu, Wang, Su, Qi, Shang, Li, Zhang and Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Caixia Liang, Medical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, China
    Hongjian Lu, Other, Nantong, China
    Yanxing Shang, Medical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, China
    Yu Li, Department of Pathogen Biology, Medical College, Nantong University, Nantong, China
    Dongmei Zhang, Medical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, China
    Chengwei Duan, Medical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, China

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