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SYSTEMATIC REVIEW article
Front. Digit. Health , 04 March 2025
Sec. Personalized Medicine
Volume 7 - 2025 | https://doi.org/10.3389/fdgth.2025.1472753
Background: Acute lung injury is a common respiratory emergency that seriously affects the life, health and quality of life of patients, especially after the global COVID-19 pneumonia. The application of nanotechnology in acute lung injury is promising. In response to the knowledge explosion resulting from rapid publication growth, we applied bibliometric analysis to explore the research profile and thematic trends in the field.
Methods: Articles and reviews related to nanotechnology in acute lung injury from 2004 to 2023 were searched. Java-based Citespace, VOSviewer, and R software-based Bibiometrix were used to systematically evaluate publications by spatiotemporal distribution, author distribution, subject categories, topic distribution, references, and keywords.
Results: A total of 1,347 publications were included. The number of papers related to nanotechnology in acute lung injury has grown exponentially over the past 20 years. China was the most productive country out of all 53 countries, followed by the United States. The Chinese Academy of Sciences was the most productive institution with 76 papers. PARTICLE AND FIBRE TOXICOLOGY was the most productive journal. The top five high-frequency keywords were inflammation, oxidative stress, toxicity, in vitro, respiratory-distress-syndrome. And the top five emerging keywords were delivery, covid-19, extracellular vesicles, therapy, sars-cov-2. Drug delivery are the focus of current research. Two emerging research areas represented the development trends: novel nanocarriers with higher efficiency and lower biotoxicity, and the other is research related to impact of nanomaterials in the progression of acute lung injury.
Conclusion: The field of nanotechnology in acute lung injury has been in a period of rapid development in the last three years. Delivery,targeted delivery and exosm have been the focus of current research in this field. Two emerging research areas represented the development trends:novel nanocarriers with higher efficiency and lower biotoxicity such as extracellular vesicles, exosomes and solid lipid nanoparticles, and the other is research related to impact of nanomaterials in the progression of acute lung injury.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious respiratory diseases (1). They present as acute and widespread pulmonary inflammation, impaired gas exchange, and hypoxemia, usually due to pulmonary or systemic factors, including pneumonia, aspiration trauma, and chest trauma (1–4). According to early studies, the mortality rate for ARDS was once as high as 50–60 percent (2). In recent years, studies have shown that, owing to improvements in mechanical ventilation strategies, this rate has fallen to between 35 and 46 percent (4). However, treatment of ALI and ARDS is primarily supportive, to maintain oxygenation and reduce lung damage (5–8). This leads to the possibility that patients who survive may experience a permanent decline in lung function, including restrictive or obstructive pulmonary hypoplasia (9–11). Particularly after the global COVID-19 pneumonia infection, a proportion of surviving patients still suffer from some degree of sclerosis and fibrosis of the lung tissue, which severely affects the quality of life (12–15). Therefore, early recognition and treatment were essential to improve prognosis in acute lung injury and ARDS. Nowadays, new therapeutic approaches were constantly being explored, especially stem cell therapy (16–20) and specific drug treatments (21–25).
Nanotechnology is a rapidly growing field. It can diagnose, treat, and prevent diseases by manipulating substances on the nanoscale (26–28). In the field of medicine, nanotechnology has an extremely wide range of applications including but not limited to drug delivery (29–31), diagnosis (32–34), imaging (35–37), therapy (28, 38–41), organizational engineering (27, 42), as well as infection control (43–46) and prevention (26, 47, 48). Presently, significant research on designing nanotechnology has been carried out and has made some research progress in the field of acute lung injury (31, 49–53). It is believed that shortly, nanomedicine can become an indispensable treatment in the field of acute lung injury.
Bibliometrics is a discipline that studies the quantitative process and law of scientific literature, which uses mathematics, statistics, and other methods to quantitatively analyze the production, distribution, dissemination, and use of scientific literature as a means of revealing the dynamics and law of scientific and technological development (54–56). In this study, we provide a comprehensive bibliometric analysis of the application of Nanotechnology in the field of acute lung injury from January 2004 to December 2023, providing a scientific performance of countries, institutions, authors, journals, and references, presenting collaborative networks and research trends from a global perspective.
Science Citation Index Expanded (SCI Expanded) of the Web of Science Core Compendium (WoSCC) was chosen as the data source. The search strategy was as follows: Topic = (nanoparticle* OR nanomedicines* OR nano* OR nanometer* OR nanomaterial* OR nanotechnology* OR nanoparticulate* OR nanocrystalline material* OR nanocomposites* OR nanoaggregates* OR nanocrystal* OR nano particle* OR nanocarrier* OR nanotherapeutic*) AND topic = ((ALI) OR (ARDS) OR (acute lung injury) OR (acute lung disease) OR (acute respiratory distress syndrome) OR (respiratory distress syndrome)) AND language = (English) AND publication year = (2004–2023). The author conducted a literature search and downloaded data in plain text or UTF-8 format. In addition, we have excluded specific types of publications and only include original articles and reviews. The literature and data search were completed on March 10th, 2024, to avoid bias caused by database updates.
We summarized the bibliometric indicators of publications, including authors, affiliated institutions, countries, number of articles, journals, keywords, references, and collaborations. Citation, G-index, and H-index were used to evaluate the academic impact of authors or journals. Journal categories (Q1, Q2, Q3, and Q4) and impact factors (IF) were excerpted from the 2023 Journal Citation Report.
We conducted a comprehensive analysis using the Java-based Citespace (version 6.3.R1), the Java program VOS Viewer (version 1.6.18), the R software-based Bibiometrix (version 3.0), and the integrated online analysis platform (https://bibliometric.com/). Citespace (version 6.3.R1) was utilized to visualize and demonstrate the structure, patterns, and dissemination of scientific knowledge. The nodes in the maps represented institutions, while the connections between nodes represented collaborations. The gauge of the lines indicated the magnitude of the relationship, and the color denoted the year of initial occurrence.
Knowledge networks of nanotechnology in acute lung injury were assessed by using co-citation analysis, co-occurrence analysis, co-authorship analysis, citation burst detection, collaborative networks, and biplot overlap of journals of journals.
This study is primarily literature-based and quantitatively analysed using mathematical and statistical methods, and does not involve human participants, human specimens or tissue, vertebrate animals or cephalopods, vertebrate embryos or tissues, field research. The primary data for this study were sourced from previously published studies, all of which had already obtained ethical approval from their respective ethics committees. Consequently, no additional ethical approval was deemed necessary for the current study. All literature searches were conducted in Web of Science.
Table 1 describes the basic information of our bibliometric analysis. In the past 20 years, 1,347 publications on the application of nanotechnology in acute lung injury have been published in 524 journals. These publications were written by 8,520 authors, including 1,114 original papers and 233 reviews, with 72,712 references cited. The average number of citations per document per year was 34.31. As shown in Figure 1A, the exponential growth in the number of publications in recent years indicates potential development in this field. The last three years alone accounted for 46.6% (628/1,347) of the publications.
Figure 1. Annual publication trends in the world (A) and in the top ten most productive countries (B).
We evaluated the performance of these countries in publications based on the nationality of the corresponding authors. Fifty-three countries have published papers on this topic. As shown in Table 2, China was the country with the highest productivity (n = 388, 28.8%), followed by the United States (n = 324, 24.1%). The top ten countries with the highest productivity include one from North America, one from South America, five from Asia, and three from Europe. The number of publications in these countries has exploded, with China performing outstandingly in the past three years (Figure 1B). The United States has the highest number of citations [n = 16,324, average article citation (AAC) = 50.40], followed by China (n = 9,617, AAC=24.80) and France (n = 2,130, AAC = 73.40). Mexico has the highest citation count of 127.00.
We have built a global collaborative network for nanotechnology in acute lung injury. Figure 2A shows that although there was cooperation among many countries, the number of collaborative publications was still relatively low. We mapped our cooperation to a global map and found that the cooperation areas were mainly concentrated in North America, Europe, East Asia, and Oceania. The collaboration was primarily focused on the United States-China (Figure 2B).
Figure 2. The country distribution (A) and international collaboration (B) of publications in the field of nanotechnology in acute lung injury.
CHINESE ACADEMY OF SCIENCES was the most productive institution with 76 publications. Ranked second through fifth were HARVARD UNIVERSITY (n = 71), EGYPTIAN KNOWLEDGE BANK (EKB, n = 69), HELMHOLTZ ASSOCIATION (n = 59), and UNIVERSITY OF PENNSYLVANIA (n = 59). Seven of the top ten institutions were from the United States, one from China, one from Egypt, and one from Germany, demonstrating the significant influence of North America in this field (Figure 3A).
Figure 3. Publication performance of the institution: the top ten most productive institutions (A); inter-institutional collaboration network (B); and co-authorship analysis of institutions (C).
We conducted a co-authorship analysis of institutions with at least five publications (Figure 3C). The National Research Centre for the Working Environment had the highest total link strength (TLS) at 44, the second through fifth places were the Technical University of Denmark (n = 41), CHINESE ACADEMY OF SCIENCES (n = 41), University of Copenhagen (n = 34), and Shanghai Jiao Tong University (n = 26). Based on further indications from the collaborative network, we did not find an obvious core institution for the cluster, suggesting that inter-institutional collaboration was not close (Figure 3B).
The top ten most cited authors are shown in Table 3 and the most prolific authors are in Table 4. Curiously, it's hard to find a clear consistency between the number of publications and the total citations. DONALDSON K was the most cited author (TC = 1,760, NP = 4). REED KL, WARHEIT DB, and WEBB TR rank second in total citations (TC = 1,553, NP = 2). VOGEL U was the most prolific author (TC = 755, NP = 20). WANG Y ranks second in productivity (TC = 159, NP = 16). This proves that four papers researched by DONALDSON K were of high academic standard and reference value. Meanwhile, REED KL, WARHEIT DB, and WEBB TR might be co-authors of the same two high-level publications. As shown in Figure 4A, collaborative network analysis revealed eight author clusters, with Vogel U and Rothen-Rutishauser B located at the center of their respective clusters. We also analyzed the changes in the works of top authors over time (Figure 4B). Thirteen of the 20 authors have been deeply involved in this field for over a decade. Notably, most of the authors have experienced a scholarly explosion after 2014, with a staggering number of publications and citations.
Figure 4. Publication performance of the authors: the inter-author collaboration network (A); and top authors’ production over time (B).
The most productive journal published on nanotechnology in acute lung injury was PARTICLE AND FIBRE TOXICOLOGY. It published 41 related publications and received 2,433 citations. The JOURNAL OF CONTROLLED RELEASE (n = 27, citations = 1,115) and ACS NANO (n = 26, citations = 1,514) were second and third. Three of the top ten most productive journals belonged to JCR Q1 and four to JCR-Q2 (Table 5). This proves that most of the journals on this topic have a high academic impact. Setting the minimum number of citations to 20 in the journal co-citation network (Figure 5), JOURNAL OF CONTROLLED RELEASE had the highest total link strength (TLS) of 124,338. The second through fifth places were PLOS ONE (TLS = 99,759), ACS NANO (TLS = 96,112), PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (TLS = 95,500) and BIOMATERIALS (TLS = 83,959). The visualization of the density of co-citation networks revealed that ACS NANO, PARTICLE AND FIBRE TOXICOLOGY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, JOURNAL OF CONTROLLED RELEASE and PLOS ONE in the core position.
Figure 5. Publication performance of the journals: co-citation network (A); and density visualization (B).
Dual map overlay of journals shows the distribution of topics (Figure 6). The citing journals are on the left, and the cited journals are on the right. The labels represent the disciplines covered by the journals, and the colored path represented the citation relationship. We can see the most important six paths. The two purple citation paths indicate that research in Chemistry/Materials/Physics journals and Molecular/Biology/Genetics journals were frequently cited by Chemistry/Materials/Physics journals. The four yellow citation paths indicate that research in Chemistry/Materials/Physics journals, Molecular/Biology/Genetics journals, Environmental/Toxicology/Nutrition journals and Healthy/Nursing/Medicine journals were frequently cited by Molecular/Biology/Immunology journals.
Table 6 lists the top ten most cited articles. These highly cited studies were published from 2004 to 2020, with 8 of them published after 2010. The most cited paper was written by WARHEIT DB (57) and published in 2004, which compared pulmonary toxicity of single-wall carbon nanotubes in rats. We constructed a co-citation reference network (Figures 7A,B). It consists of the four highest clusters of TLS publications written by LENZ AG(TLS = 257), Oberdörster G(TLS = 151), MATTHAY MA(TLS = 158), and HOFFMANN M(TLS = 51). Figure 7C shows the top 20 references with the strongest citation burst. The journal with the greatest contribution was PART FIBRE TOXICOL, with a total of 4 publications, followed by TOXICOL APPL PHARM, J AEROSOL SCI, and PLOS ONE, all with a total of 2 publications. The citation explosion occurred after 2014 and experienced rapid turnover.
Figure 7. Highly contributive papers: a co-citation network (A) and density visualization (B) of references; and the top 20 references with the strongest citation bursts (C).
VOSviewer parameters were as follows: Method (Linlog/modularity) and a minimum number of occurrences of a keyword: 20. There were 6,892 keywords, with 95 keywords meeting the thresholds. For each of 95 keywords, the total strength of co-occurrence links with other keywords was calculated. Keywords with the greatest total link strength were selected. The keyword co-occurrence network graph (Figure 8A) displays that the thicker the connection between nodes, the higher the frequency of two keywords appearing together. Keywords formed four clusters, representing the four main research directions nanotechnology and acute lung injury.
The red cluster mainly includes acute lung injury, respiratory-distress-syndrome, delivery, covid-19, drug-delivery, lung injury, extracellular vesicles, therapy, nanomedicine, exosomes, drug delivery, model, sars-cov-2, inhibition, cancer, sepsis, pulmonary surfactant, lipopolysaccharide, ards, nanotechnology, mesenchymal stem-cells, pathogenesis, curcumin, pulmonary delivery, microvesicles, release, acute respiratory distress syndrome, infection, targeted delivery, liposomes, stromal cells, receptor, formulation, nanocarriers, polymeric nanoparticles, coronavirus, pneumonia, stem-cells, ali, protein, design, and lung-cancer.
The green cluster mainly contains nanoparticles, toxicity, in vitro, lung, exposure, particles, inhalation, mice, air-liquid interface, epithelial-cells, cytotoxicity, carbon nanotubes, intratracheal instillation, pulmonary toxicity, nanoparticle, responses, nanomaterials, ultrafine particles, particulate matter, nanotoxicology, air-pollution, lung inflammation, rats, silver nanoparticles, deposition, size, alveolar macrophages, translocation, and system.
The blue cluster mainly comprises inflammation, oxidative stress, cells, activation, expression, macrophages, mechanisms, injury, apoptosis, disease, nf-kappa-b, fibrosis, antioxidant, cytokines, asthma, autophagy, obstructive pulmonary-disease, and gene-expression.
The yellow cluster mainly consists of in vivo, biodistribution, gold nanoparticles, pulmonary inflammation, neutrophils, and pharmacokinetics.
In addition to nanoparticles (TLS = 2,357) and acute lung injury (TLS = 1,784), keywords with higher frequency in this study include inflammation (TLS = 1,808), oxidative stress (TLS = 1,364), toxicity (TLS = 1,040), in vitro (TLS = 1,030), respiratory-distress-syndrome (TLS = 674), activation (TLS = 634), covid-19 (TLS = 626), particles (TLS = 616), drug-delivery (TLS = 605), and inhalation (TLS = 601). Among these keywords, all of these TLS appeared more than 600 times, indicating that they were the focus of research.
The temporal evolution of keywords was shown in Figure 8B. The more yellow color indicates that the keyword was more emerging. The top ten high-frequency emerging keywords were delivery (TLS = 654), covid-19 (TLS = 626), extracellular vesicles (TLS = 410), therapy (TLS = 376), sars-cov-2 (TLS = 354), exosomes (TLS = 332), cancer (TLS = 291), sepsis (TLS = 285), inhibition (TLS = 281), and mesenchymal stem-cells (TLS = 218). Additionally, we conducted keyword trend analyses (Figure 8C). The research hotspots in the last three years were delivery/drug-delivery/inflammation (2021), exosomes/solid lipid nanoparticles/covid-19 (2022), resistance/pneumonia/alzheimers-disease (2023).
Combined with Keyword explosion detection, we further analyzed the popularity trend of keywords. Figure 9 intuitively shows the stage hotspots and development directions of nanotechnology and acute lung injury research from the time dimension. The blue line denotes the time axis while the red segment on the blue time axis demonstrates the burst detection, indicating the start year, end year, and burst duration. The top 25 keywords with the strongest citation bursts in nanotechnology and acute lung injury were carbon nanotubes (2004), pulmonary toxicity (2004), ultrafine particles (2008), particles (2008), air pollution (2008), intratracheal instillation (2009), respiratory tract (2010), mice (2011), in vivo (2011), epithelial cells (2011), surface area (2011), inhalation exposure (2012), mouse lung (2013), rats (2014), walled carbon nanotubes (2014), cardiovascular disease (2015), endothelial cells (2016), cytokine storm (2020), stromal cells (2021), targeted delivery (2021), spike protein (2021), pulmonary drug delivery (2021), exosm (2021), solid lipid nanoparticles (2021), and delivery (2021). Targeted delivery (2021–2024), exosm (2021–2024), and delivery (2021–2024) were the current research frontiers in nanotechnology and acute lung injury, and they were already in an explosive period.
We provided an insight into the global knowledge landscape and trends in nanotechnology in acute lung injury through bibliometric analysis. China was a leader in this field. Delivery,targeted delivery and exosm have been the focus of current research in this field. Two emerging research areas represented the development trends:novel nanocarriers with higher efficiency and lower biotoxicity such as extracellular vesicles, exosomes and solid lipid nanoparticles, and the other is research related to impact of nanomaterials in the progression of acute lung injury. This report could serve as a reference and guide for more in-depth studies in the future.
This study systematically presents the global research overview and macro patterns of publications in the field of nanotechnology in acute lung injury by spatiotemporal distribution, author distribution, subject categories, topic distribution, references, and keywords. It was expected that this study will serve as a reference and guide for analyzing the current status of the field and for more in-depth research in the future.
Our findings show a significant increase over the past 20 years. Although the use of nanotechnology in acute lung injury is not new, we have been faced with a dramatic increase in the literature over the past three years (46.6%, 628/1,347). China (n = 388, 28.8%) was the most productive country out of all 53 countries, followed by the United States (n = 324, 24.1%). The top ten countries with the highest productivity include one from North America, one from South America, five from Asia, and three from Europe. The United States has the highest number of citations [n = 16,324, average article citation (AAC) = 50.40], followed by China (n = 9,617, AAC = 24.80) and France (n = 2,130, AAC = 73.40). Mexico has the highest citation count of 127.00. The global collaborative network for nanotechnology in acute lung injury showed that although there was cooperation among many countries, the number of collaborative publications was still relatively low. We mapped our cooperation to a global map and found that the cooperation areas were mainly concentrated in North America, Europe, East Asia, and Oceania. The collaboration was primarily focused on the United States-China. As a result, China and the United States are international leaders in this field and have developed a deep level of co-operation. It is easy to understand, as the development of high technology is closely related to economic power.
Furthermore, seven of the top ten institutions in terms of publications were from the United States, one from China, one from Egypt, and one from Germany, demonstrating the significant influence of North America in this field. However, the Chinese Academy of Sciences was the most published institution with 76 papers. This indicates that Chinese research institutions were also making important contributions in this field. It also shows that other Chinese research organisations have a greater potential for development. Deeper multi-agency co-operation is likely to be one of the main directions for the future.
Analysis of high-frequency keywords reflects the hotspots in a particular research field. We explored the evolution of research concepts and hot-spots in the field through keyword co-occurrence analysis and burst detection. Cluster analysis based on keywords, finally forming a cluster of four colors. Then, according to the analysis of the top 25 keywords with the strongest citation bursts, the research hotspots and frontiers in nanotechnology and acute lung injury were determined. The present study revealed that nanoparticle drug delivery was the most important and cutting-edge application of nanotechnology in acute lung injury, and it was foreseeable that a greater number of investigations would focus on this area in the future.
Nanomedicine is an interdisciplinary science that combines nanoscience, nano-engineering, and nanotechnology with life sciences (57–60). The field of nanomedicine aims to utilize the nature and physical properties of nanomaterials to diagnose and treat diseases at the molecular level (61). Until now, nanotechnology has been an extremely wide range of applications including but not limited to drug delivery (29–31), diagnosis (32–34), imaging (35–37), therapy (28, 38–41), organizational engineering (27, 42), as well as infection control (43–46) and prevention (26, 47, 48). Nanomaterials were a key part of nanomedicine. There were many types of nanomaterials, many of which can replicate the functions of some spherical biomolecules. For example, liposomes (62), different polymer nanostructures (63), protein structures (64), carbon dots (65), nanodiamonds (66), carbon nanotubes (67), graphene, and inorganic nanomaterials such as mesoporous silica (MSNP) (68), superparamagnetic iron oxide nanomaterials (SPIONs) (69), and quantum dots (QDs) (70). These nanomaterials have different applications in the field of medicine due to their different properties.
Meanwhile, researchers have continuously optimised the composition and structure of nanomaterials to obtain nanocarriers with higher drug delivery efficiency and lower biotoxicity. And the effect of nanomaterials in disease progression has also been intensively researched (31, 49–53). In the progression of ARDS, excessive production of reactive oxygen species (ROS) can lead to uncontrolled inflammatory responses. A 2023 study found that the functional nanomaterial Molybdenum nanodots (MNDs), with superior properties such as ultra-small size, good biocompatibility and excellent ROS scavenging ability, could protect lung tissue by inhibiting the activation of NOD-like receptor protein 3 (NLRP3) (52). The oxidative stress, inflammation, protein permeability, and histological severity of ALI mice were significantly improved by intratracheal administration (52). Cerium oxide nanoparticle (CNP) carriers, constructed in another study in 2021, can deliver unstable therapeutic drugs such as anti-inflammatory microRNA-146a locally to injured lungs via intratracheal administration without systemic absorption (49). CNP-miR146a improves lung biomechanics in acute lung injury after bleomycin exposure by altering leukocyte recruitment, reducing inflammation and oxidative stress, and reducing collagen deposition (49). Liposomes prepared using the thin-film aqueous method can bind to the epigenetic regulatory protein BRD4 to construct BRD4 siRNA and cationic lipid complexes (71). BRD4 siRNA liposomes (BRD4-SIRNA-LP) inhibit lung inflammatory cells, lipopolysaccharide (LPS) -induced neutrophil infiltration and mast cell aggregation, and LPS-induced cytokine storms and inflammatory signaling pathways, and improve lung compliance (71).
Carbon nanotubes are one of the most common nanomaterials. According to Figure 9, we discovered the use of carbon nanotubes in acute lung injury as early as 2004. Carbon nanotubes present a wide range of application prospects due to their unique structure and excellent mechanical, electrical and chemical properties. It has attracted great attention from many scientists in the fields of materials, physics, electronics, chemistry, etc., and has become the research frontier and hotspot in the field of international new materials (72). Furthermore,magnetic nanoparticles recently in few decades have proved as an effective advanced drug delivery system for its elevated magnetic responsiveness, biocompatibility, elevated targeted drug delivery effectiveness. In the presence of an external magnetic field, the drug can be easily targeted to the active site. Owing to their easy execution towards drug delivery application, extensive research has been carried out in this area (73).
In the wake of the COVID-19 pandemic, vaccination has emerged as the most effective method of disease prevention, and public confidence in vaccines depends on their safety and efficacy (74). Among them, the delivery of proteins and DNA/RNAs has become an important challenge (74, 75).The field of vaccine development is entering a new nano-era. In July 2020, the SARS-CoV-2 vaccine portfolio included 158 vaccine candidates (74, 75). Approximately 20 of these agents were in advanced stages of development, including mRNA-based vaccines, adenovirus-based vaccines, and pathogen-specific vaccines (74, 75). In the summer of 2020, experimental vaccines showing promising results in clinical trials were based on inactivated or attenuated live viruses, protein subunits, virus-like particles, viral vectors, and chemically synthesized nanoparticles (NPs, liposomes) delivered with DNA and mRNA (75). So far dozens of COVID-19 vaccines are in clinical trials or have passed clinical trials (76–80). And according to the keyword trend chart (Figure 8C),We find that COVID-19 becomes a popular keyword in 2022, which indicates that 2022 is an output year for COVID-19-related scientific research.
In addition to synthetic nanoparticles, bioderived nanoscale extracellular vesicles have also become a research hotspot (81–83). Compared with synthetic nanoparticles, extracellular vesicles (EVs) have good biocompatibility, low immunogenicity, natural cell targeting, and complex biomolecular loading capacity (84–86). Exosomes isolated from conditioned cultures of lentivirus-transfected mouse pulmonary microvascular endothelial cells (MPMVECs) were found to be useful for intratracheal injections for the treatment of lipopolysaccharide (LPS)-induced ALI in mice (87). Studies have found that inhalation of exosomes can improve pulmonary edema and inflammation, reduce the number of cells and protein levels in bronchoalveolar lavage fluid (BALF), and reduce the expression of pro-inflammatory cytokines such as IL-1 beta, TNF-α and IL-6 (87). In another study, neutrophil membrane-engineered Panax ginseng root-exosome (N-exo)-loaded microRNA (miRNA) 182-5p (N-exo-miRNA 182-5p) was found to have a favourable therapeutic effect on acute lung injury (ALI) in sepsis (88). The study found that N-exo-miRNA 182-5p significantly improved ALI by targeting and modulating the NOX4/Drp-1/NLRP3 signaling pathway in vivo and in vitro (88).
In addition, through the above studies, we found that in the treatment of lung diseases, aerosol inhalation has become an indispensable drug delivery route (49, 52, 87). Aerosol inhalation delivers drugs directly to the lungs and airways. Compared with the intravenous route, aerosol inhalation of the drug mainly acts locally, reducing the amount entering the systemic circulation, which may reduce systemic side effects (85–90). Thus, biogenic extracellular vesicle nebulized inhalation has great potential for the treatment of acute lung injury.
It should be noted that our study still has some limitations. First, although WoSCC is the most commonly used data source for bibliometric analysis. However, ignoring publications from other databases may lead to selection bias. Therefore, more rigorous analyses should be conducted in the future using more databases. Second, only SCI-Expanded articles and reviews in English were included in this study. Next, open-source journals have an impact on both citations and publication sit require a certain amount of time for an article to reach a high academic impact after publication. Finally, bibliometric analyses were usually conducted annually, and some recently published literature was not included in the assessment. Given the rapid growth of the field, more findings may emerge in future updated studies.
The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding authors.
JZ: Conceptualization, Investigation, Software, Writing – original draft, Writing – review & editing. SJ: Data curation, Methodology, Supervision, Writing – original draft, Writing – review & editing. JJ: Formal Analysis, Project administration, Validation, Writing – original draft, Writing – review & editing. YL: Funding acquisition, Resources, Visualization, Writing – original draft, Writing – review & editing.
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Natural Science Foundation of China (82303293, 31971318, 21876205, 22027810, and 32101091), Youth Foundation of PLA General Hospital (22QNFC078).
We are grateful to those who have assisted with this Research Project.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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Keywords: bibliometric analysis, nanotechnology, acute lung injury, drug delivery, research trend
Citation: Zhang J, Jiang S, Jiang J and Liu Y (2025) Global research landscape on nanotechnology in acute lung injury: a bibliometric analysis. Front. Digit. Health 7:1472753. doi: 10.3389/fdgth.2025.1472753
Received: 30 July 2024; Accepted: 14 February 2025;
Published: 4 March 2025.
Edited by:
Paraskevi Papadopoulou, American College of Greece, GreeceReviewed by:
Kajal Ghosal, Jadavpur University, IndiaCopyright: © 2025 Zhang, Jiang, Jiang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jipeng Jiang, MTM1MDIwMzQzNjBAMTYzLmNvbQ==; Yang Liu, bGl1eWFuZzMwMTMwMUAxMjYuY29t
†These authors have contributed equally to this work
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