Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 19 Feb 2025

Therapeutic potential of Laurus nobilis extract by experimental and computational approaches: phenolic content and bioactivities for antioxidant, antidiabetic, and anticholinergic properties

in Medicinal and Pharmaceutical Chemistry

Sevgi Altın
Mesut Işık
Cemalettin Alp
Emrah Dikici
Ekrem Köksal
Kevser Kübra Kırboğa
Mithun Rudrapal
Gourav Rakshit
Şükrü Beydemir
Johra Khan

Frontiers in Chemistry

doi 10.3389/fchem.2025.1541250

146 views

Original Research

Accepted on 17 Feb 2025

Exploring Shared Therapeutic Targets for Alzheimer's Disease and Glioblastoma Using Network Pharmacology and Protein-Protein Interaction Approach`

in Medicinal and Pharmaceutical Chemistry

Sushma Pradeep
Sai Chakith M. R.
Sindhushree Sr
Pruthvish Reddy
Esther Sushmitha
Madhusudan N Purohit
Divya Suresh
Nanjunda Swamy
Ekaterina Silina
Natalia Manturova

Frontiers in Chemistry

doi 10.3389/fchem.2025.1549186

Original Research

Published on 13 Feb 2025

Anti-proliferative effects of a polyherbal formulation on HL-60, HCT-116, and HeLa cell lines: a docking simulation and response surface design-aided study

in Medicinal and Pharmaceutical Chemistry

Chukwuebuka Egbuna
Kingsley C. Patrick-Iwuanyanwu
Eugene N. Onyeike
Johra Khan
Sahar AlDosari
Sadaf Jahan
Kamoru A. Adedokun
Sikiru O. Imodoye
Ibrahim O. Bello
Chukwuemelie Z. Uche

Frontiers in Chemistry

doi 10.3389/fchem.2025.1487887

337 views

Original Research

Accepted on 12 Feb 2025

Antioxidant Activity and Selective Cytotoxicity in HCT-116 and WI-38 cell Lines of LC-MS/MS profiled extract from Capparis spinosa L

in Medicinal and Pharmaceutical Chemistry

Amjad Ibrahim Oraibia
Ashour H. Dawoodd
Ghada Trabelsi
Ousman B.Mahamat
Leila chekir -Ghedira
Soumaya Kilani

Frontiers in Chemistry

doi 10.3389/fchem.2025.1540174

Original Research

Published on 12 Feb 2025

Design, synthesis, and in vitro, in vivo, and in silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents

in Medicinal and Pharmaceutical Chemistry

Tulika Anthwal
Swati Pant
Preeti Rana
Sumitra Nain

Frontiers in Chemistry

doi 10.3389/fchem.2024.1515866

321 views

Original Research

Accepted on 10 Feb 2025

Elicitor-Driven Enhancement of Phenolic Compounds in Geranium Callus Cultures: Phytochemical Profiling via LC-MS/MS and Biological Activities

in Medicinal and Pharmaceutical Chemistry

Amine ELBOUZIDI
Mohamed Taibi
Abdellah Baraich
Mounir Haddou
Ramzi Mothana
Sami A Alsufyani
Hany Darwish
Roland Molinié
Jean-Xavier Fontaine
Ophelie Fliniaux

Frontiers in Chemistry

doi 10.3389/fchem.2025.1537877

Original Research

Accepted on 10 Feb 2025

Composite Nanoparticles-based Vesicles Achieve Enhanced Delivery Effect of the Natural Plant Extract of Root, Stem, and Fruit

in Medicinal and Pharmaceutical Chemistry

Xiaodong Zhuang
Ting Ma
Risheng Liu
Xingyue Fang
Liangjiu Huang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1552298

Original Research

Accepted on 07 Feb 2025

Chemoinformatics analysis of Mangifera indica leaves extracted phytochemicals as potential EGFR kinase modulators

in Medicinal and Pharmaceutical Chemistry

Md. Abdullah Al Mashud
Ajoy Kumer
Ismat Jahan
Md. Mehedi Hasan Somrat
Md. Enamul Kabir Talukder
Md Mashiar Rahman
A F M Shahab Uddin
Md. Mizanur Rahman
Mohammad Harun-Ur-Rashid
Gamal A. Shazly

Frontiers in Chemistry

doi 10.3389/fchem.2025.1524384

125 views

Original Research

Accepted on 05 Feb 2025

Discovery of triazole derivatives for biofilm disruption, anti-inflammation and metal ion chelation

in Medicinal and Pharmaceutical Chemistry

Shuang Hong
Hongzhi Lu
Dawei Tian
Yue Chang
Qi Lu
Feng Gao

Frontiers in Chemistry

doi 10.3389/fchem.2025.1545259

Correction

Accepted on 04 Feb 2025

Antioxidant, Anti-Alzheimer’s, anticancer, and cytotoxic properties of peanut oil: in vitro, in silico, and GC-MS analysis

in Medicinal and Pharmaceutical Chemistry

Hanane Djeghim
BENOUCHENNE Djamila
El Hassen Mokrani
Huda Alsaeedi
David CORNU
Mikhael Bechelany
Ahmed Barhoum

Frontiers in Chemistry

doi 10.3389/fchem.2025.1563210

Original Research

Accepted on 04 Feb 2025

Designing Novel Cabozantinib Analogues as p-glycoprotein Inhibitors to Target Cancer Cell Resistance using Molecular Docking Study, ADMET Screening, Bioisosteric Approach, and Molecular Dynamics Simulations

in Medicinal and Pharmaceutical Chemistry

Gajendra Singh Thakur
Ajay Kumar Gupta
Dipti Pal
Yogesh Vaishnav
Neeraj Kumar
Sivakumar Annadurai
Sanmati Kumar Jain

Frontiers in Chemistry

doi 10.3389/fchem.2025.1543075

Original Research

Published on 04 Feb 2025

Molecular characterization, chemical profile and biological properties of essential oils from Chamaemelum nobile (L.) flowers of Morocco: in vitro and in silico studies

in Medicinal and Pharmaceutical Chemistry

El-Mehdi El-Assri
Youssef El-Assri
Rajae El Brahimi
Mohamed El fadili
Asmae Baghouz
Hatem A. Abuelizz
Sara Er-Rahmani
Amal Lahkimi
Abdelhak Bouia

Frontiers in Chemistry

doi 10.3389/fchem.2025.1539872

310 views

Original Research

Accepted on 03 Feb 2025

Insight into loading, release, and anticancer activities of the methanol hybridized glauconite nanosheets as a potential carrier of cisplatin: equilibrium and release kinetics

in Medicinal and Pharmaceutical Chemistry

Haifa E. Alfassam
Nourhan Nasser
Sarah I. Othman
Hanan M. Alharbi
Mostafa R. Abukhadra
Ahmed A. Allam
Mostafa R. Abukhadra

Frontiers in Chemistry

doi 10.3389/fchem.2025.1523664

Original Research

Accepted on 03 Feb 2025

Novel Idebenone Derivatives Attenuated Oxidative Stress Injury And Myocardial Damage

in Medicinal and Pharmaceutical Chemistry

Yuwei Peng
Yishan Guo
Xinyi Yang
Yulan Liu
Xun Xu
Junhong Chen
Xueyi Liu
Zhenrou Xie
Zhiqiang Yu
Dudu Wu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1544616

Editorial

Published on 03 Feb 2025

Editorial: Exploring novel approaches to small molecule kinase inhibitors in cancer treatment

in Medicinal and Pharmaceutical Chemistry

Anna Carbone
Rafael M. Couñago
Cristian O. Salas
Alessandra Moltalbano

Frontiers in Chemistry

doi 10.3389/fchem.2025.1559849

362 views

Original Research

Accepted on 31 Jan 2025

Exploring the antimicrobial potential of lactobacilli against early-stage and mature biofilms of Staphylococcus aureus and Pseudomonas aeruginosa

in Medicinal and Pharmaceutical Chemistry

NIHARIKA SINGH
Rohini Devidas Gulhane
Maitri Goel
Pudke Payal Udelal
Anamika Singh
Vikas Sangwan
Manvesh Kumar Sihag
Gunjan Goel
Harsh Panwar
Anil Kumar Puniya

Frontiers in Chemistry

doi 10.3389/fchem.2025.1425666

136 views

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Articles

Therapeutic potential of Laurus nobilis extract by experimental and computational approaches: phenolic content and bioactivities for antioxidant, antidiabetic, and anticholinergic properties

Exploring Shared Therapeutic Targets for Alzheimer's Disease and Glioblastoma Using Network Pharmacology and Protein-Protein Interaction Approach`

Anti-proliferative effects of a polyherbal formulation on HL-60, HCT-116, and HeLa cell lines: a docking simulation and response surface design-aided study

Antioxidant Activity and Selective Cytotoxicity in HCT-116 and WI-38 cell Lines of LC-MS/MS profiled extract from Capparis spinosa L

Design, synthesis, and in vitro, in vivo, and in silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents

Elicitor-Driven Enhancement of Phenolic Compounds in Geranium Callus Cultures: Phytochemical Profiling via LC-MS/MS and Biological Activities

Composite Nanoparticles-based Vesicles Achieve Enhanced Delivery Effect of the Natural Plant Extract of Root, Stem, and Fruit

Chemoinformatics analysis of Mangifera indica leaves extracted phytochemicals as potential EGFR kinase modulators

Discovery of triazole derivatives for biofilm disruption, anti-inflammation and metal ion chelation

Antioxidant, Anti-Alzheimer’s, anticancer, and cytotoxic properties of peanut oil: in vitro, in silico, and GC-MS analysis

Designing Novel Cabozantinib Analogues as p-glycoprotein Inhibitors to Target Cancer Cell Resistance using Molecular Docking Study, ADMET Screening, Bioisosteric Approach, and Molecular Dynamics Simulations

Molecular characterization, chemical profile and biological properties of essential oils from Chamaemelum nobile (L.) flowers of Morocco: in vitro and in silico studies

Insight into loading, release, and anticancer activities of the methanol hybridized glauconite nanosheets as a potential carrier of cisplatin: equilibrium and release kinetics

Novel Idebenone Derivatives Attenuated Oxidative Stress Injury And Myocardial Damage

Editorial: Exploring novel approaches to small molecule kinase inhibitors in cancer treatment

Exploring the antimicrobial potential of lactobacilli against early-stage and mature biofilms of Staphylococcus aureus and Pseudomonas aeruginosa