Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Accepted on 22 Apr 2025

Discovery of a novel binding pocket in PPAR for partial agonists: structure-based virtual screening identifies ginsenoside Rg5 as a partial agonist promoting beige adipogenesis

in Medicinal and Pharmaceutical Chemistry

Zhen Wang
Kexin Shui
Zehui Zhang
Yihan Chen
Nanfei Yang
Shiliang Ji
Pingping Shen
Qiang Tian

Frontiers in Chemistry

doi 10.3389/fchem.2025.1579445

Original Research

Published on 22 Apr 2025

Toxicity mechanism analysis of cGAS-STING-TBK1 signaling pathway small molecule modulator based on network toxicology and molecular docking strategy: quinacrine acetate as an example

in Medicinal and Pharmaceutical Chemistry

Jinchao Zhu
Qingyuan Lin
Honglin Zhu
Siqi Xie
Shengdong Nie

Frontiers in Chemistry

doi 10.3389/fchem.2025.1584588

266 views

Original Research

Accepted on 21 Apr 2025

Proposal of a new chemical marker for the quality control of the herb Scleromitrion diffusum

in Medicinal and Pharmaceutical Chemistry

Tao Zheng
Chu-Chu Zhong
Grace Gar-Lee Yue
Dong-Min Jiang
Man-Ho Tong
Hiu-Yan Wong
Kwan-Ho Wong
Menghua Wu
David Tai-Wai Lau
Hui Cao

Frontiers in Chemistry

doi 10.3389/fchem.2025.1600769

Review

Accepted on 21 Apr 2025

Modification of Biopharmaceutical Parameters of Flavonoids: A Review

in Medicinal and Pharmaceutical Chemistry

Amir Taldaev
Artem A. Svotin
Semyon I. Obukhov
Roman P. Terekhov
Irina A. Selivanova

Frontiers in Chemistry

doi 10.3389/fchem.2025.1602967

Original Research

Accepted on 18 Apr 2025

Design, synthesis, and biological investigation of new thiazole-based derivatives as multi-targeted inhibitors endowed with antiproliferative, antioxidant, and antibacterial properties

in Medicinal and Pharmaceutical Chemistry

Hesham A M Gomaa
Asmaa M Atta
Mohamed E. Shaker
Sami Alzarea
Tariq Alsahli
Eid Alatwi
Arafa Musa
Fatma A M Mohamed
Hayat Ali Alzahrani
Aliaa M Mohassab

Frontiers in Chemistry

doi 10.3389/fchem.2025.1595997

Original Research

Accepted on 16 Apr 2025

Mechanism of Hedysari Radix Praeparata Cum Melle and Curcumae Rhizoma Herb Pair in Colitis-Associated Colorectal Cancer through the MAPK/NF-κB signaling pathway: An Investigation In Vivo and In Vitro

in Medicinal and Pharmaceutical Chemistry

Ting Liu
Zhuanhong Zhang
Feiyun Gao
Yugui Zhang
Maomao Wang
Cui Ma
Yanjun Wang
Dingcai Ma
Zhe Wang
Xingke Yan

Frontiers in Chemistry

doi 10.3389/fchem.2025.1551722

Review

Published on 16 Apr 2025

Research progress on extraction, separation, structure, and biological activities of polysaccharides from jujube fruit (Ziziphus jujuba Mill.): a review

in Medicinal and Pharmaceutical Chemistry

Feilong Jia
Bo Wang
Hui Ma
Changcai Bai
Yuanyuan Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1581947

328 views

Original Research

Published on 16 Apr 2025

Design, synthesis, in silico studies, and apoptotic antiproliferative activity of novel thiazole-2-acetamide derivatives as tubulin polymerization inhibitors

in Medicinal and Pharmaceutical Chemistry

Lamya H. Al-Wahaibi
Ali M. Elshamsy
Taha F. S. Ali
Bahaa G. M. Youssif
Stefan Bräse
Mohamed Abdel-Aziz
Nawal A. El-Koussi

Frontiers in Chemistry

doi 10.3389/fchem.2025.1565699

513 views

Original Research

Published on 16 Apr 2025

Computational identification of potential natural terpenoid inhibitors of MDM2 for breast cancer therapy: molecular docking, molecular dynamics simulation, and ADMET analysis

in Medicinal and Pharmaceutical Chemistry

Eva Azme
Md. Mahmudul Hasan
Md. Liakot Ali
Rashedul Alam
Neamul Hoque
Fabiha Noushin
Mohammed Fazlul Kabir
Ashraful Islam
Tanzina Sharmin Nipun
S. M. Moazzem Hossen

Frontiers in Chemistry

doi 10.3389/fchem.2025.1527008

908 views

Original Research

Accepted on 14 Apr 2025

Development of Nifedipine Isosteres: An Integrated Approach 2 to Design, Synthesis, and Biological Assessment of Calcium 3 Channel Blockers 4

in Medicinal and Pharmaceutical Chemistry

Yasser Zohny
Samir M Awad
Omar Alsaidam
Maha A Rabie

Frontiers in Chemistry

doi 10.3389/fchem.2025.1581037

122 views

Original Research

Published on 10 Apr 2025

Antioxidant activity and selective cytotoxicity in HCT-116 and WI-38 cell lines of LC-MS/MS profiled extract from Capparis spinosa L

in Medicinal and Pharmaceutical Chemistry

Amjad Ibrahim Oraibi
Ashour H. Dawood
Ghada Trabelsi
Ousman B. Mahamat
Leila Chekir-Ghedira
Soumaya Kilani-Jaziri

Frontiers in Chemistry

doi 10.3389/fchem.2025.1540174

499 views
1 citation

Original Research

Accepted on 09 Apr 2025

Effect of Freeze-pressure regulated extraction Technology on the physicochemical properties and pharmacological activities of Guizhi extract

in Medicinal and Pharmaceutical Chemistry

Huiling Zhang
Juanzhen Luo
Qinzhao Wan
Xuecheng Wang
Zhenfeng Wu
Ming Yang
Yaqi Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1581429

123 views

Original Research

Accepted on 08 Apr 2025

In silico investigation of potential antineoplastic suberitenones from Antarctic Sponge Suberites sp: network pharmacology, QSAR, ADMET, molecular docking, and molecular dynamics simulation approaches

in Medicinal and Pharmaceutical Chemistry

Prasenjit Bhowmik
Rahul Mallick
Asim K Duttaroy

Frontiers in Chemistry

doi 10.3389/fchem.2025.1545834

161 views

Original Research

Published on 04 Apr 2025

Discovery of a novel 4-pyridyl SLC-0111 analog targeting tumor-associated carbonic anhydrase isoform IX through tail-based design approach with potent anticancer activity

in Medicinal and Pharmaceutical Chemistry

Hamada Hashem
Shadwa Abdelfattah
Hesham M. Hassan
Ahmed Al-Emam
Mohammed Alqarni
Ghallab Alotaibi
Ibrahim Taha Radwan
Kirandeep Kaur
Devendra Pratap Rao
Stefan Bräse

Frontiers in Chemistry

doi 10.3389/fchem.2025.1571646

799 views

Mini Review

Published on 01 Apr 2025

4-Aminoquinoline: a comprehensive review of synthetic strategies

in Medicinal and Pharmaceutical Chemistry

Francisco Delgado
Andrés Benítez
Lourdes Gotopo
Angel H. Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1553975

800 views

Original Research

Published on 01 Apr 2025

Healing and leishmanicidal activity of Zanthoxylum rhoifolium Lam.

in Medicinal and Pharmaceutical Chemistry

Juliana Correa-Barbosa
Heliton Patrick Cordovil Brígido
Bibiana Franzen Matte
Paloma Santos De Campos
Marcelo Lazzaron Lamers
Daniele Ferreira Sodré
Pedro Henrique Costa Nascimento
Gleison Gonçalves Ferreira
Valdicley Vieira Vale
Andrey Moacir do Rosário Marinho

Frontiers in Chemistry

doi 10.3389/fchem.2025.1504998

511 views