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ORIGINAL RESEARCH article

Front. Chem.
Sec. Medicinal and Pharmaceutical Chemistry
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1473097

Synthesis of new triazole derivatives and their potential applications for removal of heavy metals from aqueous solution and antibacterial activities

Provisionally accepted
Chunyun Xu Chunyun Xu *Na Yang Na Yang Haichun Yu Haichun Yu Xiaojing Wang Xiaojing Wang
  • Qinhuangdao Maternal and Child Health Hospital, Qinhuangdao, China

The final, formatted version of the article will be published soon.

    In this paper, triazole derivatives were prepared by a three-step mild reaction using carbon disulfide as starting material. In face of microbial threats, we found that compound 3-cyclopropyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole-6-thiol (C2) has good antibacterial activity, inhibition and clearance ability against biofilms, low hemolytic activity and toxicity, good anti-inflammatory activity. At the same time, we found that B and C series compounds have good metal ion scavenging ability, with removal rates of C series ranging from 47% to 67% and B series ranging from 67% to 87%.

    Keywords: 1, 2, 4-triazole derivatives, Antibacterial activity, Anti biofilm, Anti inflammatory, Metal ion detection

    Received: 30 Jul 2024; Accepted: 11 Oct 2024.

    Copyright: © 2024 Xu, Yang, Yu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chunyun Xu, Qinhuangdao Maternal and Child Health Hospital, Qinhuangdao, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.