AUTHOR=Xu Chunyun , Yang Na , Yu Haichun , Wang Xiaojing 

TITLE=Synthesis of new triazole derivatives and their potential applications for removal of heavy metals from aqueous solution and antibacterial activities

JOURNAL=Frontiers in Chemistry

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2024.1473097

DOI=10.3389/fchem.2024.1473097

ISSN=2296-2646

ABSTRACT=<p>In this paper, triazole derivatives were prepared by a three-step mild reaction using carbon disulfide as starting material. In face of microbial threats, we found that compound 3-cyclopropyl-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazole-6-thiol (<bold>C2</bold>) has good antibacterial activity, inhibition and clearance ability against biofilms, low hemolytic activity and toxicity, good anti-inflammatory activity. At the same time, we found that <bold>B</bold> and <bold>C</bold> series compounds have good metal ion scavenging ability, with removal rates of <bold>C</bold> series ranging from 47% to 67% and <bold>B</bold> series ranging from 67% to 87%.</p>