The final, formatted version of the article will be published soon.
REVIEW article
Front. Chem. Biol.
Sec. Molecular Sciences
Volume 4 - 2025 |
doi: 10.3389/fchbi.2025.1441138
This article is part of the Research Topic Investigating Small Molecule Selectivity in Chemical Biology: Protein Kinases and GPCRs View all articles
Biology and Pharmacological Inhibition of Homeodomain-interacting Protein Kinases (HIPK)
Provisionally accepted- Masaryk University, Brno, Czechia
Homeodomain-interacting protein kinases (HIPKs) represent a relatively underexplored sub-family of serine/threonine protein kinases. However, the recently published studies point to the role of HIPKs in the developmental biology and etiology of pathological states, in particular cancer, and potential therapeutic applications of targeting this kinase family. This review summarizes the biology of HIPKs and their heretofore published small-molecule inhibitors.
Keywords: HIPK, kinase, inhibitor, Selectivity, Neurology, Cancer
Received: 30 May 2024; Accepted: 24 Jan 2025.
Copyright: © 2025 Paruch and Stefek. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kamil Paruch, Masaryk University, Brno, Czechia
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.