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ORIGINAL RESEARCH article

Front. Cell. Neurosci.
Sec. Cellular Neuropathology
Volume 18 - 2024 | doi: 10.3389/fncel.2024.1424137

Cycloastragenol Promotes Dorsal Column Axon Regeneration in Mice

Provisionally accepted
XXX Saijilafu XXX Saijilafu *
  • Hangzhou City University, Hangzhou, China

The final, formatted version of the article will be published soon.

    Cycloastragenol (CAG) has a wide range of pharmacological effects, including anti-inflammatory, antiaging, antioxidative, and antitumorigenic properties. In addition, our previous study showed that CAG administration can promote axonal regeneration in peripheral neurons. However, whether CAG can activate axon regeneration central nervous system (CNS) remains unknown. Here, we established a novel mouse model for visualizing spinal cord dorsal column axon regeneration involving the injection of AAV2/9-Cre into the lumbar 4/5 dorsal root ganglion (DRG) of Rosa-tdTomato reporter mice. We then treated mice by intraperitoneal administration of CAG. Our results showed that intraperitoneal CAG injection significantly promoted the growth of vitro-cultured DRG axons as well as the growth of dorsal column axons over the injury site in spinal cord injury (SCI) mice. Our results further indicate that CAG administration can promote the recovery of sensory, and urinary function in SCI mice. Together, our findings highlight the therapeutic potential of CAG in spinal cord injury repair.

    Keywords: Cycloastragenol, dorsal column, axon growth, Nerve injury, functional recovery, TERT, spinal cord injury, p53

    Received: 18 Jun 2024; Accepted: 04 Dec 2024.

    Copyright: © 2024 Saijilafu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: XXX Saijilafu, Hangzhou City University, Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.