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REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Virus and Host
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1547873
Understanding the role of trehalose in interactions between Wolbachia and Aedes aegypti
Provisionally accepted- 1 Institut Pasteur, Paris, France
- 2 Institut Pasteur de Nouvelle Calédonie, Noumea, New Caledonia
Mosquito-borne diseases such as chikungunya, dengue, and Zika represent a major burden on global public health. To fight against these arboviruses, vector control strategies are a priority.One existing strategy is based on the use of an endosymbiotic bacterium, Wolbachia, which reduces the transmission of arboviruses by the mosquito Aedes aegypti via a pathogen blocking effect. Wolbachia in Ae. aegypti disrupts several pathways of the host's metabolism. Trehalose is a carbohydrate circulating mainly in insect hemolymph and plays a role in numerous mechanisms as energy source or stress recovery molecule and in chitin synthesis. This study explores the importance of trehalose in the interactions between Wolbachia and Ae. aegypti, and attempts to understand the pathogen blocking effect.
Keywords: Trehalose, Wolbachia, pathogen-blocking effect, Aedes aegypti, antioxidant, Autophagy
Received: 18 Dec 2024; Accepted: 04 Mar 2025.
Copyright: © 2025 DUPUIS, POCQUET and FAILLOUX. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Anna-Bella FAILLOUX, Institut Pasteur, Paris, France
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