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REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Extra-intestinal Microbiome
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1518811
This article is part of the Research Topic Skin Microbiome: Microbiological, Immunological and Cellular aspects for therapies to control Antimicrobial Resistance and Skin Repair View all articles

Skin microbiota: Pathogenic roles and implications in atopic dermatitis

Provisionally accepted
Cong Huang Cong Huang 1*Fan Zhuo Fan Zhuo 1Yang Guo Yang Guo 1Siyu Wang Siyu Wang 1Kaoyuan Zhang Kaoyuan Zhang 1Xiahong Li Xiahong Li 1Wenkui Dai Wenkui Dai 2Xia Dou Xia Dou 1*Bo Yu Bo Yu 1*
  • 1 Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen CN, China
  • 2 Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen CN, China

The final, formatted version of the article will be published soon.

    Atopic dermatitis (AD) is a chronic and inflammatory skin disorder characterized by impaired barrier function and imbalanced immunity. Recent advances have revealed that dysbiosis of skin microbiota plays important roles in the pathogenesis and development of AD. Meanwhile, endogenous and external factors contribute to the dysbiosis of skin microbiota in AD. Additionally, various treatments, including topical treatments, phototherapy, and systemic biologics, have demonstrated positive impacts on the clinical outcomes, alongside with the modulations of cutaneous microbiota in AD patients. Importantly, therapeutics or products regulating skin microbiota homeostasis have demonstrated potential for AD treatment in early clinical studies. In this review, we underline changes of the skin microbiota correlated with AD. Meanwhile, we provide an overview of the skin microbiota regarding its roles in the 2 pathogenesis and development of AD. Finally, we summarize therapeutic strategies restoring the skin microbial homeostasis in AD management.

    Keywords: atopic dermatitis, Skin microbiota, Staphylococcus aureus, Pathogenesis, Microbiota-based therapy

    Received: 30 Oct 2024; Accepted: 27 Dec 2024.

    Copyright: © 2024 Huang, Zhuo, Guo, Wang, Zhang, Li, Dai, Dou and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Cong Huang, Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen CN, China
    Xia Dou, Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen CN, China
    Bo Yu, Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen CN, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.