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MINI REVIEW article

Front. Cell. Infect. Microbiol.
Sec. Oral Microbes and Host
Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1493818
This article is part of the Research Topic Dental diseases: In the spotlight of oral microbiome and host immune defenses - New approaches for Oral Health and Oral Care View all articles

Inflammation and immune response in the development of periodontal disease: A narrative review

Provisionally accepted
Nansi López-Valverde Nansi López-Valverde *Norberto Quispe-López Norberto Quispe-López José Antonio Blanco José Antonio Blanco
  • University of Salamanca, Salamanca, Spain

The final, formatted version of the article will be published soon.

    We present this critical review with the aim of highlighting the current status of periodontal diseases, focusing on the relevance of host modulating agents and immune pathways, in addition to new complementary therapeutic approaches for the treatment of these pathologies.Periodontal diseases are prevalent pathologies worldwide and the main cause of edentulism in the adult population. Their pathogenesis seems to be based on a dysbiosis of the oral microbiota that interacts with the host's immune defenses and is responsible for the inflammatory/immune response, which would be modified by a number of conditions such as individual susceptibility, environmental and sociodemographic factors, certain systemic pathologies and the individual's genetic condition, among others.Numerous studies have reported on the complex web of inflammatory mediators in periodontal disease and their role in tissue destruction as well as in homeostatic imbalance. Precisely, the role of epigenetics as a modifier of the host genetic condition has captured research attention in recent years.Therefore, this mini-review first discusses an updated etiological hypothesis of periodontal disease and the roles of certain cytokines in the immune response. In addition, the latest therapeutic trends with new developments and future perspectives are summarized.

    Keywords: Inflammation1, immune response2, pyroptosis3, inflammasome4, periodontal disease5

    Received: 09 Sep 2024; Accepted: 14 Nov 2024.

    Copyright: © 2024 López-Valverde, Quispe-López and Blanco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Nansi López-Valverde, University of Salamanca, Salamanca, Spain

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