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REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Virus and Host
Volume 14 - 2024 |
doi: 10.3389/fcimb.2024.1457617
This article is part of the Research Topic Virus-Induced Autophagy in Host Cells During Viral Infections View all 3 articles
Interaction between coronaviruses and the autophagic response
Provisionally accepted- China Animal Health and Epidemiology Center, Qingdao, Shandong Province, China
In recent years, the emergence and widespread dissemination of the coronavirus SARS-CoV-2 has posed a significant threat to global public health and social development. In order to safely and effectively prevent and control the spread of coronavirus diseases, a profound understanding of virus-host interactions is paramount. Cellular autophagy, a process that safeguards cells by maintaining cellular homeostasis under diverse stress conditions. Xenophagy, specifically, can selectively degrade intracellular pathogens, such as bacteria, fungi, viruses, and parasites, thus establishing a robust defense mechanism against such intruders. Coronaviruses have the ability to induce autophagy, and they manipulate this pathway to ensure their efficient replication. While progress has been made in elucidating the intricate relationship between coronaviruses and autophagy, a comprehensive summary of how autophagy either benefits or hinders viral replication remains elusive. In this review, we delve into the mechanisms that govern how different coronaviruses regulate autophagy. We also provide an in-depth analysis of virus-host interactions, particularly focusing on the latest data pertaining to SARS-CoV-2. Our aim is to lay a theoretical foundation for the development of novel coronavirus vaccines and the screening of potential drug targets.
Keywords: Coronavirus, SARS-CoV-2, Autophagy, Virus Replication, immune response
Received: 01 Jul 2024; Accepted: 18 Oct 2024.
Copyright: © 2024 Yu, Ge, Li, Zhang, Xu, Wang, Liu, Yu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shengqiang Ge, China Animal Health and Epidemiology Center, Qingdao, Shandong Province, China
Jinming Li, China Animal Health and Epidemiology Center, Qingdao, Shandong Province, China
Yingli Wang, China Animal Health and Epidemiology Center, Qingdao, Shandong Province, China
Shan Liu, China Animal Health and Epidemiology Center, Qingdao, Shandong Province, China
Xiaojing Yu, China Animal Health and Epidemiology Center, Qingdao, Shandong Province, China
Zhiliang Wang, China Animal Health and Epidemiology Center, Qingdao, Shandong Province, China
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