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REVIEW article

Front. Cell Dev. Biol.
Sec. Morphogenesis and Patterning
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1510862
This article is part of the Research Topic Extracellular Vesicles Signaling in Embryogenesis and Morphogenesis View all articles

Exosomes: New Targets for Understanding Axon Guidance in the Developing Central Nervous System

Provisionally accepted
Mingyu Liu Mingyu Liu TENG TENG TENG TENG *
  • Hainan Medical University, Haikou, China

The final, formatted version of the article will be published soon.

    Axon guidance is a key event in neural circuit development that drives the correct targeting of axons to their targets through long distances and unique patterns. Exosomes, extracellular vesicles that are smaller than 100 nm, are secreted by most cell types in the brain. Regulation of cell-cell communication, neuroregeneration, and synapse formation by exosomes have been extensively studied. However, the interaction between exosomes and axon guidance molecules is poorly understood. This review summarizes the relationship between exosomes and canonical and non-canonical guidance cues and hypothesizes a possible model for exosomes mediating axon guidance between cells. The roles of exosomes in axon outgrowth, regeneration, and neurodevelopmental disorders are also reviewed, to discuss exosome-guidance interactions as potential clinical therapeutic targets.

    Keywords: axon guidance, central nervous system development, Exosomes, Neurodevelopmental disorders, Neuronal circuit formation

    Received: 14 Oct 2024; Accepted: 19 Dec 2024.

    Copyright: © 2024 Liu and TENG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: TENG TENG, Hainan Medical University, Haikou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.