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REVIEW article

Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1466997

Understanding the Impact of ER stress on Lung Physiology

Provisionally accepted
Zhiling Fu Zhiling Fu 1Wei Wang Wei Wang 1*Yuan Gao Yuan Gao 2*
  • 1 anesthesiology department, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China
  • 2 Department of pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Human lungs consist of a distinctive array of cell types, which are subjected to persistent challenges from chemical, mechanical, biological, immunological, and xenobiotic stress throughout life. The disruption of endoplasmic reticulum (ER) homeostatic function, triggered by various factors, can induce ER stress. To overcome the elevated ER stress, an adaptive mechanism known as the unfolded protein response (UPR) is activated in cells. However, persistent ER stress and maladaptive UPR can lead to defects in proteostasis at the cellular level and are typical features of the lung aging. The aging lung and associated lung diseases exhibit signs of ER stress-related disruption in cellular homeostasis. Dysfunction resulting from ER stress and maladaptive UPR can compromise various cellular and molecular processes associated with aging. Hence, comprehending the mechanisms of ER stress and UPR ling 删除[作者]:components implicated in aging and associated lung diseases could enable to develop appropriate therapeutic strategies for the vulnerable population.

    Keywords: ERstress, upr, Autophagy, Aging, Lung dysfunction

    Received: 24 Jul 2024; Accepted: 22 Nov 2024.

    Copyright: © 2024 Fu, Wang and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wei Wang, anesthesiology department, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China
    Yuan Gao, Department of pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.